Sökning: WFRF:(Schubert Ulrich S.)
> (2011) >
Metal-Free 1,5-Regi...
Abstract
Ämnesord
Stäng
- [3+2]-cycloaddition reactions of aromatic azides and silylated alkynes in aqueous media yield 1,5-disubstituted-4-(trimethyl-silyl)-1H-1,2,3-triazoles. The formation of the 1,5-isomer is highly favored in this metal-free cycloaddition, which could be proven by 1D selective NOESY and X-ray investigations. Additionally, DFT calculations corroborate the outstanding favoritism regarding the 1,5-isomer. The described method provides a simple alternative protocol to metal-catalyzed "click chemistry" procedures, widening the scope for regioselective heavy-metal-free synthetic applications.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- alkynes
- azides
- click chemistry
- cycloaddition
- regioselectivity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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