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Sökning: WFRF:(Schuermans A) > (2024) > Clonal haematopoies...

Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias

Schuermans, Art (författare)
Massachusetts General Hospital,Broad Institute
Vlasschaert, Caitlyn (författare)
Nauffal, Victor (författare)
Broad Institute,Brigham and Women's Hospital / Harvard Medical School
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Cho, So Mi Jemma (författare)
Massachusetts General Hospital,Broad Institute,Yonsei University
Uddin, Md Mesbah (författare)
Massachusetts General Hospital,Broad Institute
Nakao, Tetsushi (författare)
Dana-Farber Cancer Institute,Brigham and Women's Hospital / Harvard Medical School,Broad Institute,Massachusetts General Hospital
Niroula, Abhishek (författare)
Lund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Dana-Farber Cancer Institute,Broad Institute
Klarqvist, Marcus D.R. (författare)
Broad Institute
Weeks, Lachelle D. (författare)
Dana-Farber Cancer Institute
Lin, Amy E. (författare)
Brigham and Women's Hospital / Harvard Medical School,Dana-Farber Cancer Institute
Saadatagah, Seyedmohammad (författare)
Baylor College of Medicine
Lannery, Kim (författare)
Broad Institute,Massachusetts General Hospital
Wong, Megan (författare)
Broad Institute,Massachusetts General Hospital
Hornsby, Whitney (författare)
Massachusetts General Hospital,Broad Institute
Lubitz, Steven A. (författare)
Massachusetts General Hospital,Broad Institute,Harvard Medical School
Ballantyne, Christie (författare)
Baylor College of Medicine
Jaiswal, Siddhartha (författare)
Stanford University School of Medicine
Libby, Peter (författare)
Brigham and Women's Hospital / Harvard Medical School
Ebert, Benjamin L. (författare)
Harvard Medical School,Dana-Farber Cancer Institute,Howard Hughes Medical Institute
Bick, Alexander G. (författare)
Vanderbilt University Medical Center
Ellinor, Patrick T. (författare)
Harvard Medical School,Broad Institute,Massachusetts General Hospital
Natarajan, Pradeep (författare)
Broad Institute,Massachusetts General Hospital,Harvard Medical School
Honigberg, Michael C. (författare)
Massachusetts General Hospital,Broad Institute,Harvard Medical School
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 (creator_code:org_t)
2024
2024
Engelska 15 s.
Ingår i: European Heart Journal. - 0195-668X. ; 45:10, s. 791-805
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background and Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutaAims tions, is associated with atherosclerotic cardiovascular disease and heart failure. This study aimed to test the association of CHIP with new-onset arrhythmias.Methods UK Biobank participants without prevalent arrhythmias were included. Co-primary study outcomes were supraventricular arrhythmias, bradyarrhythmias, and ventricular arrhythmias. Secondary outcomes were cardiac arrest, atrial fibrillation, and any arrhythmia. Associations of any CHIP [variant allele fraction (VAF) ≥ 2%], large CHIP (VAF ≥10%), and gene-specific CHIP subtypes with incident arrhythmias were evaluated using multivariable-adjusted Cox regression. Associations of CHIP with myocardial interstitial fibrosis [T1 measured using cardiac magnetic resonance (CMR)] were also tested. Results This study included 410 702 participants [CHIP: n = 13 892 (3.4%); large CHIP: n = 9191 (2.2%)]. Any and large CHIP were associated with multi-variable-adjusted hazard ratios of 1.11 [95% confidence interval (CI) 1.04–1.18; P = .001] and 1.13 (95% CI 1.05–1.22; P = .001) for supraventricular arrhythmias, 1.09 (95% CI 1.01–1.19; P = .031) and 1.13 (95% CI 1.03–1.25; P = .011) for bradyarrhythmias, and 1.16 (95% CI, 1.00–1.34; P = .049) and 1.22 (95% CI 1.03–1.45; P = .021) for ventricular arrhythmias, respectively. Associations were independent of coronary artery disease and heart failure. Associations were also heterogeneous across arrhythmia subtypes and strongest for cardiac arrest. Gene-specific analyses revealed an increased risk of arrhythmias across driver genes other than DNMT3A. Large CHIP was associated with 1.31-fold odds (95% CI 1.07–1.59; P = .009) of being in the top quintile of myocardial fibrosis by CMR. Conclusions CHIP may represent a novel risk factor for incident arrhythmias, indicating a potential target for modulation towards arrhythmia prevention and treatment.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Aging
Arrhythmia
Atrial fibrillation
Cardiac arrest
Genomics
Prevention

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