Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease: A Randomized Controlled Trial-The OmegAD Study

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Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease : A Randomized Controlled Trial-The OmegAD Study

Tofiq, avin, 1996- (författare): School of Medicine, Örebro University, Örebro, Sweden,Örebro Univ, Sch Med, Örebro, Sweden.

Zetterberg, Henrik (författare): Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL, London, United Kingdom; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom,Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Mölndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Mölndal, Sweden.;UCL, UK Dementia Res Inst, London, England.;UCL Inst Neurol, Dept Neurodegenerat Dis, London, England.

Blennow, Kaj (författare): Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden,Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Mölndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Mölndal, Sweden.

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Basun, Hans (författare): BioArctic AB, Stockholm, Sweden; Spinemedical AB, Stockholm, Sweden; Uppsala University Hospital, Uppsala, Sweden,BioArctic AB, Stockholm, Sweden.;Spinemed AB, Stockholm, Sweden.;Uppsala Univ Hosp, Uppsala, Sweden.

Cederholm, Tommy (författare): Uppsala universitet,Klinisk nutrition och metabolism,Karolinska Univ Hosp, Theme Ageing, Stockholm, Sweden.

Eriksdotter, Maria (författare): Karolinska Institutet,Karolinska Univ Hosp, Theme Ageing, Stockholm, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.

Faxén-Irving, Gerd (författare): Karolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.

Hjorth, Erik (författare): Karolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.

Jernerén, Fredrik (författare): Uppsala universitet,Institutionen för farmaceutisk biovetenskap

Schultzberg, Marianne (författare): Karolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.

Wahlund, Lars-Olof (författare): Karolinska Institutet,Karolinska Univ Hosp, Theme Ageing, Stockholm, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.

Palmblad, Jan (författare): Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp Huddinge, Dept Med, Stockholm, Sweden.

Freund-Levi, Yvonne, 1956- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden; Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University Hospital Örebro, Örebro, Sweden; Department of Old Age Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom,Örebro Univ, Sch Med, Örebro, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Div Clin Geriatr, Stockholm, Sweden.;Univ Hosp Örebro, Dept Psychiat, Örebro, Sweden.;Kings Coll London, Dept Old Age Psychiat Psychol & Neurosci, London, England.

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School of Medicine, Örebro University, Örebro, Sweden Örebro Univ, Sch Med, Örebro, Sweden (creator_code:org_t)

IOS Press, 2021
2021
Engelska.
Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 83:3, s. 1291-1301

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.3...; http://kipublication...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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BACKGROUND: Studies have suggested a connection between a decrease in the levels of polyunsaturated fatty acids (PUFAs) and Alzheimer's disease (AD). We aimed to assess the effect of supplementation with omega-3 fatty acids (n-3 FAs) on biomarkers analyzed in the cerebrospinal fluid (CSF) of patients diagnosed with AD.OBJECTIVE: To investigate the effects of daily supplementation with 2.3 g of PUFAs in AD patients on the biomarkers in CSF described below. We also explored the possible correlation between these biomarkers and the performance in the cognitive test Mini-Mental State Examination (MMSE).METHODS: Thirty-three patients diagnosed with AD were randomized to either treatment with a daily intake of 2.3 g of n-3 FAs (n = 18) or placebo (n = 15). CSF samples were collected at baseline and after six months of treatment, and the following biomarkers were analyzed: Aβ 38, Aβ 40, Aβ 42, t-tau, p-tau, neurofilament light (NfL), chitinase-3-like protein 1 (YKL-40), acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), soluble IL-1 receptor type II (sIL-1RII), and IL-6.RESULTS: There were no significant differences between the groups concerning the level of the different biomarkers in the CSF at baseline. Within the treatment group, there was a small but significant increase in both YKL-40 (p = 0.04) and NfL (p = 0.03), while the other CSF biomarkers remained stable.CONCLUSION: Supplementation with n-3 FAs had a statistically significant effect on NfL and YKL-40, resulting in an increase of both biomarkers, indicating a possible increase of inflammatory response and axonal damage. This increase in biomarkers did not correlate with MMSE score.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Dementia
Chitinase-3-like protein 1
YKL-40
inflammation
mini-mental state examination
neurodegeneration
neurofilament light

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Av författaren/redakt...: Tofiq, avin, 199 ...; Zetterberg, Henr ...; Blennow, Kaj; Basun, Hans; Cederholm, Tommy; Eriksdotter, Mar ...; visa fler...; Faxén-Irving, Ge ...; Hjorth, Erik; Jernerén, Fredri ...; Schultzberg, Mar ...; Wahlund, Lars-Ol ...; Palmblad, Jan; Freund-Levi, Yvo ...; visa färre...

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Av lärosätet: Örebro universitet; Karolinska Institutet; Uppsala universitet

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