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Study protocol of comprehensive risk evaluation for anorexia nervosa in twins (CREAT) : a study of discordant monozygotic twins with anorexia nervosa.
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- Seidel, Maria (författare)
- Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Fetscherstr 74, D-01307 Dresden, Germany.;Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17165 Stockholm, Solna, Sweden.
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- Ehrlich, Stefan (författare)
- Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Fetscherstr 74, D-01307 Dresden, Germany.
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- Breithaupt, Lauren (författare)
- Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.;Massachusetts Gen Hosp, Eating Disorders Clin & Res Program, Boston, MA 02114 USA.
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- Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Fetscherstr 74, D-01307 Dresden, Germany;Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17165 Stockholm, Solna, Sweden. Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Fetscherstr 74, D-01307 Dresden, Germany. (creator_code:org_t)
- 2020-10-14
- 2020
- Engelska.
- Ingår i: BMC Psychiatry. - : BioMed Central. - 1471-244X. ; 20:1
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- BACKGROUND: Anorexia nervosa (AN) is a severe disorder, for which genetic evidence suggests psychiatric as well as metabolic origins. AN has high somatic and psychiatric comorbidities, broad impact on quality of life, and elevated mortality. Risk factor studies of AN have focused on differences between acutely ill and recovered individuals. Such comparisons often yield ambiguous conclusions, as alterations could reflect different effects depending on the comparison. Whereas differences found in acutely ill patients could reflect state effects that are due to acute starvation or acute disease-specific factors, they could also reflect underlying traits. Observations in recovered individuals could reflect either an underlying trait or a "scar" due to lasting effects of sustained undernutrition and illness. The co-twin control design (i.e., monozygotic [MZ] twins who are discordant for AN and MZ concordant control twin pairs) affords at least partial disambiguation of these effects.METHODS: Comprehensive Risk Evaluation for Anorexia nervosa in Twins (CREAT) will be the largest and most comprehensive investigation of twins who are discordant for AN to date. CREAT utilizes a co-twin control design that includes endocrinological, neurocognitive, neuroimaging, genomic, and multi-omic approaches coupled with an experimental component that explores the impact of an overnight fast on most measured parameters.DISCUSSION: The multimodal longitudinal twin assessment of the CREAT study will help to disambiguate state, trait, and "scar" effects, and thereby enable a deeper understanding of the contribution of genetics, epigenetics, cognitive functions, brain structure and function, metabolism, endocrinology, microbiology, and immunology to the etiology and maintenance of AN.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Anorexia nervosa
- Cognitive functions
- Genetics
- Metabolism
- Microbiota
- Neuroimaging
- Risk factors
- Study protocol
- Twin study
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