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Inhibition of fatty...
Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma
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- Ruiz-Pérez, María Victoria (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Biomed B7, S-17165 Stockholm, Sweden.
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- Sainero-Alcolado, Lourdes (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Biomed B7, S-17165 Stockholm, Sweden.
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- Oliynyk, Ganna (författare)
- Karolinska Institute,Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Biomed B7, S-17165 Stockholm, Sweden.
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- Matuschek, Isabell (författare)
- Karolinska Institute,Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Biomed B7, S-17165 Stockholm, Sweden.
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- Balboni, Nicola (författare)
- Karolinska Institute,Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Biomed B7, S-17165 Stockholm, Sweden.
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- Ubhayasekera, Kumari (författare)
- Uppsala universitet,Uppsala University,Analytisk kemi,Science for Life Laboratory, SciLifeLab
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- Snaebjornsson, Marteinn Thor (författare)
- German Cancer Research Centre,German Canc Res Ctr, Tumor Metab & Microenvironm, D-69120 Heidelberg, Germany.
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- Makowski, Kamil (författare)
- University of Barcelona,Univ Barcelona, Fac Chem, Dept Inorgan & Organ Chem, Sect Organ Chem, Barcelona 08028, Spain.
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- Aaltonen, Kristina (författare)
- Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molecular Pediatric Oncology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Translat Canc Res, S-22381 Lund, Sweden.
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- Bexell, Daniel (författare)
- Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molecular Pediatric Oncology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Translat Canc Res, S-22381 Lund, Sweden.
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- Serra, Dolors (författare)
- Carlos III Health Institute,University of Barcelona,CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),Univ Barcelona, Dept Biochem & Physiol, Sch Pharm, Inst Biomed,Univ Barcelona IBUB, Barcelona 08028, Spain.;Inst Hlth Carlos III, BER Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
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- Nilsson, Roland (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Dept Med, Cardiovasc Med Unit, S-17176 Stockholm, Sweden.;Karolinska Univ Hosp, Div Cardiovasc Med, S-17176 Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, S-17176 Stockholm, Sweden.
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- Bergquist, Jonas (författare)
- Uppsala universitet,Uppsala University,Analytisk kemi,Science for Life Laboratory, SciLifeLab
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- Schulze, Almut (författare)
- German Cancer Research Centre,German Canc Res Ctr, Tumor Metab & Microenvironm, D-69120 Heidelberg, Germany.
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- Arsenian-Henriksson, Marie (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Biomed B7, S-17165 Stockholm, Sweden.
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: iScience. - : Elsevier BV. - 2589-0042. ; 24:2
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://www.cell.com/...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Many metabolic pathways, including lipid metabolism, are rewired in tumors to support energy and biomass production and to allow adaptation to stressful environments. Neuroblastoma is the second deadliest solid tumor in children. Genetic aberrations, as the amplification of the MYCN-oncogene, correlate strongly with disease progression. Yet, there are only a few molecular targets successfully exploited in the clinic. Here we show that inhibition of fatty acid synthesis led to increased neural differentiation and reduced tumor burden in neuroblastoma xenograft experiments independently of MYCN-status. This was accompanied by reduced levels of the MYCN or c-MYC oncoproteins and activation of ERK signaling. Importantly, the expression levels of genes involved in de novo fatty acid synthesis showed prognostic value for neuroblastoma patients. Our findings demonstrate that inhibition of de novo fatty acid synthesis is a promising pharmacological intervention strategy for the treatment of neuroblastoma independently of MYCN-status.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- biological sciences
- cancer
- cell biology
- molecular biology
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Ruiz-Pérez, Marí ...
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Sainero-Alcolado ...
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Oliynyk, Ganna
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Matuschek, Isabe ...
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Balboni, Nicola
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Ubhayasekera, Ku ...
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visa fler...
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Snaebjornsson, M ...
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Makowski, Kamil
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Aaltonen, Kristi ...
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Bexell, Daniel
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Serra, Dolors
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Nilsson, Roland
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Bergquist, Jonas
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Schulze, Almut
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Arsenian-Henriks ...
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