| 1. |
- Tobias, Deirdre K, et al.
(författare)
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Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
- 2023
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Ingår i: Nature Medicine. - 1546-170X. ; 29:10, s. 2438-2457
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Forskningsöversikt (refereegranskat)abstract
- Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
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| 2. |
- Vigan, A., et al.
(författare)
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The SPHERE infrared survey for exoplanets (SHINE) : III. The demographics of young giant exoplanets below 300 au with SPHERE
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 651
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Tidskriftsartikel (refereegranskat)abstract
- The SpHere INfrared Exoplanet (SHINE) project is a 500-star survey performed with SPHERE on the Very Large Telescope for the purpose of directly detecting new substellar companions and understanding their formation and early evolution. Here we present an initial statistical analysis for a subsample of 150 stars spanning spectral types from B to M that are representative of the full SHINE sample. Our goal is to constrain the frequency of substellar companions with masses between 1 and 75 MJup and semimajor axes between 5 and 300 au. For this purpose, we adopt detection limits as a function of angular separation from the survey data for all stars converted into mass and projected orbital separation using the BEX-COND-hot evolutionary tracks and known distance to each system. Based on the results obtained for each star and on the 13 detections in the sample, we use a Markov chain Monte Carlo tool to compare our observations to two different types of models. The first is a parametric model based on observational constraints, and the second type are numerical models that combine advanced core accretion and gravitational instability planet population synthesis. Using the parametric model, we show that the frequencies of systems with at least one substellar companion are 23.0−9.7+13.5, 5.8−2.8+4.7, and 12.6−7.1+12.9% for BA, FGK, and M stars, respectively. We also demonstrate that a planet-like formation pathway probably dominates the mass range from 1–75 MJup for companions around BA stars, while for M dwarfs, brown dwarf binaries dominate detections. In contrast, a combination of binary star-like and planet-like formation is required to best fit the observations for FGK stars. Using our population model and restricting our sample to FGK stars, we derive a frequency of 5.7−2.8+3.8%, consistent with predictions from the parametric model. More generally, the frequency values that we derive are in excellent agreement with values obtained in previous studies.
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| 3. |
- Biller, B. A., et al.
(författare)
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Dynamical masses for two M1 + mid-M dwarf binaries monitored during the SPHERE-SHINE survey
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 658
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Tidskriftsartikel (refereegranskat)abstract
- We present orbital fits and dynamical masses for HIP 113201AB and HIP 36985AB, two M1 + mid-M dwarf binary systems monitored as part of the SPHERE-SHINE survey. To robustly determine the age of both systems via gyrochronology, we undertook a photometric monitoring campaign for HIP 113201 and GJ 282AB, the two wide K star companions to HIP 36985, using the 40 cm Remote Observatory Atacama Desert telescope. Based on this monitoring and gyrochronological relationships, we adopt ages of 1.2 ± 0.1 Gyr for HIP 113201AB and 750 ± 100 Myr for HIP 36985AB. These systems are sufficiently old that we expect that all components of these binaries have reached the main sequence. To derive dynamical masses for all components of the HIP 113201AB and HIP 36985AB systems, we used parallel-tempering Markov chain Monte Carlo sampling to fit a combination of radial velocity, direct imaging, and Gaia and HIPPARCOS astrometry. Fitting the direct imaging and radial velocity data for HIP 113201 yields a primary mass of 0.54 ± 0.03 M⊙, fully consistent with its M1 spectral type, and a secondary mass of 0.145 ± M⊙. The secondary masses derived with and without including HIPPARCOS-Gaia data are all considerably more massive than the 0.1 M⊙ mass estimated from the photometry of the companion. Thus, the dynamical impacts of this companion suggest that it is more massive than expected from its photometry. An undetected brown dwarf companion to HIP 113201B could be a natural explanation for this apparent discrepancy. At an age >1 Gyr, a 30 MJup companion to HIP 113201B would make a negligible (<1%) contribution to the system luminosity but could have strong dynamical impacts. Fitting the direct imaging, radial velocity, and HIPPARCOS-Gaia proper motion anomaly for HIP 36985AB, we find a primary mass of 0.54 ± 0.01 M⊙ and a secondary mass of 0.185 ± 0.001 M⊙, which agree well with photometric estimates of component masses, the masses estimated from MK– mass relationships for M dwarf stars, and previous dynamical masses in the literature.
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| 4. |
- Brown-Sevilla, S. B., et al.
(författare)
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Revisiting the atmosphere of the exoplanet 51 Eridani b with VLT/SPHERE
- 2023
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 673
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We aim to better constrain the atmospheric properties of the directly imaged exoplanet 51 Eri b using a retrieval approach with data of higher signal-to-noise ratio (S/N) than previously reported. In this context, we also compare the results from an atmospheric retrieval to using a self-consistent model to fit atmospheric parameters. Methods. We applied the radiative transfer code petitRADTRANS to our near-infrared SPHERE observations of 51 Eri b in order to retrieve its atmospheric parameters. Additionally, we attempted to reproduce previous results with the retrieval approach and compared the results to self-consistent models using the best-fit parameters from the retrieval as priors. Results. We present a higher S/N YH spectrum of the planet and revised K1K2 photometry (M-K1 = 15.11 +/- 0.04 mag, M-K2 = 17.11 +/- 0.38 mag). The best-fit parameters obtained using an atmospheric retrieval differ from previous results using self-consistent models. In general, we find that our solutions tend towards cloud-free atmospheres (e.g. log tau(clouds) = 5.20 +/- 1.44). For our `nominal' model with new data, we find a lower metallicity ([Fe/H] = 0.26 +/- 0.30 dex) and C/O ratio (0.38 +/- 0.09), and a slightly higher effective temperature (T-eff = 807 +/- 45 K) than previous studies. The surface gravity (log g = 4.05 +/- 0.37) is in agreement with the reported values in the literature within uncertainties. We estimate the mass of the planet to be between 2 and 4 MJup. When comparing with self-consistent models, we encounter a known correlation between the presence of clouds and the shape of the P-T profiles. Conclusions. Our findings support the idea that results from atmospheric retrievals should not be discussed in isolation, but rather along with self-consistent temperature structures obtained using the best-fit parameters of the retrieval. This, along with observations at longer wavelengths, might help to better characterise the atmospheres and determine their degree of cloudiness.
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| 5. |
- Keppler, M., et al.
(författare)
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Gap, shadows, spirals, and streamers : SPHERE observations of binary-disk interactions in GG Tauri A
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 639
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Tidskriftsartikel (refereegranskat)abstract
- Context. A large portion of stars is found to be part of binary or higher-order multiple systems. The ubiquity of planets found around single stars raises the question of whether and how planets in binary systems form. Protoplanetary disks are the birthplaces of planets, and characterizing them is crucial in order to understand the planet formation process.Aims. Our goal is to characterize the morphology of the GG Tau A disk, one of the largest and most massive circumbinary disks. We also aim to trace evidence for binary-disk interactions.Methods. We obtained observations in polarized scattered light of GG Tau A using the SPHERE/IRDIS instrument in the H-band filter. We analyzed the observed disk morphology and substructures. We ran 2D hydrodynamical models to simulate the evolution of the circumbinary ring over the lifetime of the disk.Results. The disk and also the cavity and the inner region are highly structured, with several shadowed regions, spiral structures, and streamer-like filaments. Some of these are detected here for the first time. The streamer-like filaments appear to connect the outer ring with the northern arc. Their azimuthal spacing suggests that they may be generated through periodic perturbations by the binary, which tear off material from the inner edge of the outer disk once during each orbit. By comparing observations to hydrodynamical simulations, we find that the main features, in particular, the gap size, but also the spiral and streamer filaments, can be qualitatively explained by the gravitational interactions of a binary with a semimajor axis of similar to 35 au on an orbit coplanar with the circumbinary ring.
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