| 1. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 2. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 3. |
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| 4. |
- Auffray, Charles, et al.
(författare)
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Making sense of big data in health research: Towards an EU action plan
- 2016
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Ingår i: Genome Medicine. - : BIOMED CENTRAL LTD. - 1756-994X. ; 8:71
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Tidskriftsartikel (refereegranskat)abstract
- Medicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation combined with automation and miniaturization has triggered an explosion in data production that will soon reach exabyte proportions. How are we going to deal with this exponential increase in data production? The potential of "big data" for improving health is enormous but, at the same time, we face a wide range of challenges to overcome urgently. Europe is very proud of its cultural diversity; however, exploitation of the data made available through advances in genomic medicine, imaging, and a wide range of mobile health applications or connected devices is hampered by numerous historical, technical, legal, and political barriers. European health systems and databases are diverse and fragmented. There is a lack of harmonization of data formats, processing, analysis, and data transfer, which leads to incompatibilities and lost opportunities. Legal frameworks for data sharing are evolving. Clinicians, researchers, and citizens need improved methods, tools, and training to generate, analyze, and query data effectively. Addressing these barriers will contribute to creating the European Single Market for health, which will improve health arid healthcare for all Europearis.
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| 5. |
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| 6. |
- Korkovelos, Alexandros, et al.
(författare)
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A geospatial assessment of small-scale hydropower potential in sub-saharan Africa
- 2018
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Ingår i: Energies. - : MDPI AG. - 1996-1073. ; 11:11
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Tidskriftsartikel (refereegranskat)abstract
- Sub-Saharan Africa has been at the epicenter of an ongoing global dialogue around the issue of energy poverty. More than half of the world's population without access to modern energy services lives there. It also happens to be a sub-continent with plentiful renewable energy resource potential. Hydropower is one of them, and to a large extent it remains untapped. This study focuses on the technical assessment of small-scale hydropower (0.01-10 MW) in Sub-Saharan Africa. The underlying methodology was based on open source geospatial datasets, whose combination allowed a consistent evaluation of 712,615 km of river network spanning over 44 countries. Environmental, topological, and social constraints were included in the form of constraints in the optimization algorithm. The results are presented on a country and power pool basis.
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| 7. |
- Mentis, Dimitris, et al.
(författare)
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Assessing the technical wind energy potential in Africa a GIS-based approach
- 2015
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Ingår i: Renewable energy. - : Elsevier BV. - 0960-1481 .- 1879-0682. ; 83, s. 110-125
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Tidskriftsartikel (refereegranskat)abstract
- Nowadays, Africa faces the challenge of generating more electricity to meet existing and future demand in a sustainable way. Africa is a privileged continent in terms of wind resource regime. However, very little of this has been utilized. It is thus essential to identify and define the amount of wind energy that could be technically exploited on the continent. The utilization of wind energy is associated with a myriad of localization criteria and thus it should be systematically addressed by spatial assessments to guarantee its harmonization with socio-economic systems, infrastructure and ecosystems. This study focuses on onshore wind power on the African continent and strives to provide estimates of theoretical, geographical and technical potential based on state of the art wind power technology. Maps of wind power potential at 80m, which is the hub height of a modern wind turbine will be derived via statistical distribution of wind speed data and implementation of wind power curves. Screening criteria regarding the localization of wind farms and related to socio-economic and geographic constraints are outlined and implemented through a thorough GIS analysis. The results of this work are presented and compared with similar approaches and significant conclusions are drawn. Based on the analysis there are some countries that signify high yearly wind energy yield, such as South Africa, Sudan, Algeria, Egypt, Libya, Nigeria, Mauritania, Tunisia and Morocco, whilst Equatorial Guinea, Gabon, Central African Republic, Burundi, Liberia, Benin and Togo indicate the least wind power potential.
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| 8. |
- Mentis, Dimitris, et al.
(författare)
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Lighting the World : the first application of an open source, spatial electrification tool (OnSSET) on Sub-Saharan Africa
- 2017
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Ingår i: Environmental Research Letters. - : Institute of Physics Publishing (IOPP). - 1748-9326. ; 12:8
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Tidskriftsartikel (refereegranskat)abstract
- In September 2015, the United Nations General Assembly adopted Agenda 2030, which comprises a set of 17 Sustainable Development Goals (SDGs) defined by 169 targets. 'Ensuring access to affordable, reliable, sustainable and modern energy for all by 2030' is the seventh goal (SDG7). While access to energy refers to more than electricity, the latter is the central focus of this work. According to the World Bank's 2015 Global Tracking Framework, roughly 15% of the world's population (or 1.1 billion people) lack access to electricity, and many more rely on poor quality electricity services. The majority of those without access (87%) reside in rural areas. This paper presents results of a geographic information systems approach coupled with open access data. We present least-cost electrification strategies on a country-by-country basis for Sub-Saharan Africa. The electrification options include grid extension, mini-grid and stand-alone systems for rural, peri-urban, and urban contexts across the economy. At low levels of electricity demand there is a strong penetration of standalone technologies. However, higher electricity demand levels move the favourable electrification option from stand-alone systems to mini grid and to grid extensions.
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| 9. |
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| 10. |
- Siyal, Shahid Hussain, et al.
(författare)
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Mapping key economic indicators of onshore wind energy in Sweden by using a geospatial methodology
- 2016
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Ingår i: Energy Conversion and Management. - : Elsevier. - 0196-8904 .- 1879-2227. ; 128, s. 211-226
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Tidskriftsartikel (refereegranskat)abstract
- Due to modern advancements in renewable energy systems and increasing prices of fossil fuels wind energy is getting a lot of attention all over the world. In this regard, Sweden also fixed motivated targets to get energy supply from local renewable energy resources. So, local wind power could help the country in achieving the targets. In this study, economic indicators of wind energy were spatially estimated for Sweden by using ArcGIS tool. In order to do this, as input data one-year high resolution modeled annual average wind data was processed by means of Rayleigh distribution, wind turbine power curve, land use constraints, technical constraints and economic parameters. Based on the input data, it was concluded that Sweden possesses economically feasible wind energy resource. The results of the study indicate that southern and central regions could produce economically viable wind electricity in all aspects as compared to the northern region of the country. Lastly, it was recommended to speed up wind energy penetration in Sweden, communal awareness and acceptance regarding the resource should be increased to avoid possible misunderstanding. Additionally, the capability of the national electric grid should be enhanced to take up the large scale unpredictable wind energy resource.
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