| 1. |
- Cao, Da-fu, et al.
(författare)
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Evaluation of prestress losses in prestressed concrete specimens subjected to freeze–thaw cycles
- 2016
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Ingår i: Structure and Infrastructure Engineering. - Abington, UK : Taylor & Francis. - 1573-2479 .- 1744-8980. ; 12:2, s. 159-170
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Tidskriftsartikel (refereegranskat)abstract
- Prestressed concrete structures are considered to be reliable and durable. However, their long-term performance when subjected to frost attack is still unclear. In this work, experiments were carried out to evaluate the prestress losses in post-tensioned prestressed concrete specimens subjected to freeze–thaw cycles (FTCs). Two cases were considered: in one case, a series of specimens were prepared and tested in a freeze–thaw chamber; in the second case, the same series of specimens were tested in an indoor environment (outside the chamber). The difference between the prestress losses of the specimens inside the freeze–thaw chamber and those outside the chamber equalled the prestress losses due to FTCs. When using mathematical models to predict the prestress losses due to the FTCs, it was found that they were relatively small when the concrete was slightly damaged. However, they increased rapidly when the FTCs were repeated. The eccentricity of the prestress wires led to larger prestress losses when subjected to FTCs. Moreover, the same cross section and eccentricity resulted in similar prestress losses due to the FTCs, and the relatively high-strength concrete could withstand more FTCs.
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| 2. |
- Cardoso-Moreira, Margarida, et al.
(författare)
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Gene expression across mammalian organ development
- 2019
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Ingår i: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 571:7766, s. 505-
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Tidskriftsartikel (refereegranskat)abstract
- The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs.
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| 3. |
- Feng, Tongbao, et al.
(författare)
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miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation.
- 2016
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:13, s. 16205-16216
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Tidskriftsartikel (refereegranskat)abstract
- The long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been recently shown to be dysregulated in several cancers. However, the mechanisms underlying the role of MALAT1 in breast cancer remain unclear. Herein, we showed that MALAT1 was aberrantly increased in breast cancer tissues and cells. MALAT1-siRNA inhibited breast cancer cell proliferation and cell cycle progression in vitro and in vivo. Furthermore, MALAT1 acted as an endogenous potent regulator by directly binding to miR-124 and down-regulating miR-124 expression. In addition, MALAT1 reversed the inhibitory effect of miR-124 on breast cancer proliferation and was involved in the cyclin-dependent kinase 4 (CDK4) expression. Taken together, our data highlight the pivotal role of MALAT1 in breast cancer tumorigenesis. Moreover, the present study elucidated the MALAT1-miR-124-CDK4/E2F1 signaling pathway in breast cancer, which might provide a new approach for tackling breast cancer.
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| 4. |
- Guangming, Shao, et al.
(författare)
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A novel cooperative platform design for coupled USV-UAV systems
- 2019
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Ingår i: IEEE Transactions on Industrial Informatics. - : IEEE. - 1551-3203 .- 1941-0050. ; 15:9, s. 4913-4922
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a novel cooperative USV-UAV platform to form a powerful combination, which offers foundations for collaborative task executed by the coupled USV-UAV systems. Adjustable buoys and unique carrier deck for the USV are designed to guarantee landing safety and transportation of UAV. The deck of USV is equipped with a series of sensors, and a multi-ultrasonic joint dynamic positioning algorithm is introduced for resolving the positioning problem of the coupled USV-UAV systems. To fulfill effective guidance for the landing operation of UAV, we design a hierarchical landing guide point generation algorithm to obtain a sequence of guide points. By employing the above sequential guide points, high quality paths are planned for the UAV. Cooperative dynamic positioning process of the USV-UAV systems is elucidated, and then UAV can achieve landing on the deck of USV steadily. Our cooperative USV-UAV platform is validated by simulation and water experiments.
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| 5. |
- Li, Liang, et al.
(författare)
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A Large Catalog of Multiwavelength GRB Afterglows. I. Color Evolution and Its Physical Implication
- 2018
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Ingår i: Astrophysical Journal Supplement Series. - : Institute of Physics Publishing (IOPP). - 0067-0049 .- 1538-4365. ; 234:2
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Tidskriftsartikel (refereegranskat)abstract
- The spectrum of gamma-ray burst (GRB) afterglows can be studied with color indices. Here, we present a large comprehensive catalog of 70 GRBs with multiwavelength optical transient data on which we perform a systematic study to find the temporal evolution of color indices. We categorize them into two samples based on how well the color indices are evaluated. The Golden sample includes 25 bursts mostly observed by GROND, and the Silver sample includes 45 bursts observed by other telescopes. For the Golden sample, we find that 96% of the color indices do not vary over time. However, the color indices do vary during short periods in most bursts. The observed variations are consistent with effects of (i) the cooling frequency crossing the studied energy bands in a wind medium (43%) and in a constant-density medium (30%), (ii) early dust extinction (12%), (iii) transition from reverse-shock to forward-shock emission (5%), or (iv) an emergent SN emission (10%). We also study the evolutionary properties of the mean color indices for different emission episodes. We find that 86% of the color indices in the 70 bursts show constancy between consecutive ones. The color index variations occur mainly during the late GRB-SN bump, the flare, and early reverse-shock emission components. We further perform a statistical analysis of various observational properties and model parameters (spectral index beta(CI)(o), electron spectral indices p(CI), etc.) using color indices. Overall, we conclude that similar to 90% of colors are constant in time and can be accounted for by the simplest external forward-shock model, while the varying color indices call for more detailed modeling.
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| 6. |
- Qin, Xiao-Chuan, et al.
(författare)
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Evaluation of freeze-thaw damage on concrete material and prestressed concrete specimens
- 2016
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Ingår i: Construction and Building Materials. - : Elsevier. - 0950-0618 .- 1879-0526. ; 125, s. 892-904
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Tidskriftsartikel (refereegranskat)abstract
- The pore structure of the hardened concrete and the microscopic changes of a few selected pores throughout the freeze-thaw test were investigated by a method combining RapidAir and digital metalloscope. Traditional tests were also performed to evaluate the macroscopic change caused by freeze-thaw cycles (FTCs). The investigation shows that the concrete material, of which the spacing factor is 0.405 mm and the air content is 2.38%, can still withstand more than 300 FTCs. Severe microscopic damages occurred after approximately 200 FTCs and the freeze-thaw damage were gradually aggravated afterwards. Prestress forces have a remarkable impact on the failure pattern under FTCs. It was further found that the compressive strength as an indicator is more reliable than the relative dynamic modulus of elasticity in evaluating the freeze-thaw damage on concrete material. In addition, the test and analysis show that the measured prestress losses of bonded specimen are larger than that of unbounded specimen under the attack of FTCs due to the duct grouting effect. The ultimate freeze-thaw prestress loss is about 5% of σconσcon for both the bonded and unbonded specimens because the grouting cement paste will eventually be completely destroyed.
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| 7. |
- Shao, Xue-Feng, et al.
(författare)
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Screening of sugar alcohols and their binary eutectic mixtures as phase change materials for low-to-medium temperature thermal energy storage. (II) : Isothermal melting and crystallization behaviors
- 2019
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Ingår i: Energy. - : Elsevier. - 0360-5442 .- 1873-6785. ; 180, s. 572-583
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Tidskriftsartikel (refereegranskat)abstract
- Based on the non-isothermal phase change behaviors of twenty-one pure and mixture sugar alcohols presented in our previous study (Part 1), the isothermal melting and crystallization behaviors were further tested in this supplemental work for five selected pure sugar alcohols (xylitol, erythritol, dmannitol, d-dulcitol and inositol) and their five binary eutectic mixtures to make an advanced screening of these candidates for low-to-medium temperature latent heat storage. The isothermal melting and crystallization behaviors of these ten candidates were tested at a constant degree of superheat (10 degrees C) and various degrees of subcooling up to 210 degrees C. The phase change temperatures, degrees of supercooling and durations of phase change were determined by the recorded temperature-history curves. It was found that the incrystallizable xylitol and its eutectic mixture of xylitol (75 mol%) + erythritol with low melting points under 100 degrees C are also unable to crystallize during isothermal cool-down at any degrees of subcooling (30-90 degrees C) due to the unavailability to nucleation. The rest eight crystallizable candidates all suffer from severe supercooling and are unable to crystallize at low degrees of subcooling (<20 degrees C). They undergo both one-phase supercooling due to poor nucleation performance and two-phase supercooling, which was unable to be obtained previously by non-isothermal cooling, due to slow crystallization kinetics. However, it seems difficult to find a correlation between the observed degrees of supercooling in both the liquid and solid phases and the prescribed degrees of subcooling by only three consecutive isothermal melting and crystallization cycles, as a result of the randomness of nucleation and large size of samples. The duration of crystallization was shown to decrease with increasing the degree of subcooling for both pure and mixture sugar alcohols due to the enhanced driving force for crystallization. The durations of crystallization of the mixture sugar alcohols appear to be longer than those of their pure compounds, due to the lower thermal conductivity and higher dynamic viscosity of the mixtures. Combining the present isothermal and the previous non-isothermal test results, it has been confirmed that the difficulty in crystallization and the severe supercooling are the primary issues for sugar alcohols, which must be addressed before they can be used in real-world latent heat storage systems.
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| 8. |
- Wan, Cheng-Liang, et al.
(författare)
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Dynamics of slow electrons transmitting through straight glass capillary and tapered glass capillary
- 2016
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Ingår i: Wuli xuebao. - : Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences. - 1000-3290. ; 65:20
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Tidskriftsartikel (refereegranskat)abstract
- It has been found that the transmission rate of the electrons through insulating capillaries as a function of time/incident charge is not the same as that of the ions. The question arises that by using the electrons, if the negative charge patches can be formed to facilitate the transmission of the following electrons, thereby substantiating that the so-called guiding effect works also for electrons. This study aims to observe the time evolutions of the transmission of electrons through a straight glass tube and a tapered glass capillary. This will reveal the details of how and (or) if the negative charge patches can be formed when the electrons transport through them. In this work, a set of MCP/phosphor two-dimensional detection system based on Labview platform is developed to obtain the time evolution of the angular distribution of the transmitted electrons. The pulsed electron beams are obtained to test our detection system. The time evolution of the angular profile of 1.5 keV electrons transmitting through the glass tube/capillary is observed. The transmitted electrons are observed on the detector for a very short time and disappear for a time and then appear again for both the glass tube and tapered glass capillary, leading to an oscillation. The positive charge patches are formed in the insulating glass tube and tapered glass capillary since the secondary electron emission coefficient for the incident energy is larger than 1. It is due to the fact that fast discharge of the deposited charge leads to the increase of the transmission rate, while the fast blocking of the incident electrons due to the deposited positive charge leads to the decrease of the transmission rate. The geometrical configuration of the taper glass capillary tends to make the secondary electrons deposited at the exit part to form the negative patches that facilitate the transmission of electrons. This suggests that if the stable transmission needs to be reached for producing the electron micro-beam by using tapered glass capillaries, the steps must be taken to have the proper grounding and shielding of the glass capillaries and tubes. Our results show a difference in transmission through the insulating capillary between electrons and highly charged ions.
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