| 1. |
|
|
| 2. |
- Berntorp, Erik, et al.
(författare)
-
Consensus perspectives on prophylactic therapy for haemophilia: summary statement.
- 2003
-
Ingår i: Haemophilia. - : Wiley. - 1351-8216. ; 9:Suppl 1, s. 41278-41278
-
Tidskriftsartikel (refereegranskat)abstract
- Participants in an international conference on prophylactic therapy for severe haemophilia developed a consensus summary of the findings and conclusions of the conference. In the consensus, participants agreed upon revised definitions for primary and secondary prophylaxis and also made recommendations concerning the need for an international system of pharmacovigilance. Considerations on starting prophylaxis, monitoring outcomes, and individualizing treatment regimens were discussed. Several research questions were identified as needing further investigation, including when to start and when to stop prophylaxis, optimal dosing and dose interval, and methods for assessment of long-term treatment effects. Such studies should include carefully defined cohorts, validated orthopaedic and quality-of-life assessment instruments, and cost-benefit analyses.
|
|
| 3. |
- Boyadjiev, SA, et al.
(författare)
-
Physical map of the chromosome 6q22 region containing the oculodentodigital dysplasia locus: analysis of thirteen candidate genes and identification of novel ESTs and DNA polymorphisms
- 2002
-
Ingår i: Cytogenetic and genome research. - : S. Karger AG. - 1424-8581 .- 1424-859X. ; 98:1, s. 29-37
-
Tidskriftsartikel (refereegranskat)abstract
- Oculodentodigital dysplasia (ODDD) is an autosomal dominant condition with congenital anomalies of the craniofacial and limb regions and neurodegeneration. Genetic anticipation for the dysmorphic and neurologic features has been inferred in a few families. Our previous linkage studies have refined the ODDD candidate region to chromosome 6q22→q23. In an attempt to clone the ODDD gene, we created a yeast artificial chromosome contig with 31 redundant clones spanning the region and identified and ordered candidate genes and markers. Fluorescent <i>in situ</i> hybridization mapped two of these YAC clones to chromosome 6q22.2 telomeric to a known 6q21 fragile site, excluding it as a possible cause of the suggested anticipation. We performed mutation analysis on thirteen candidate genes – GRIK2, HDAC2, COL10A1, PTD013, KPNA5, PIST, ROS1, BRD7, PLN, HSF2, PKIB, FABP7, and HEY2. Although no mutations were found, we identified 44 polymorphisms, including 28 single nucleotide polymorphisms. Direct cDNA selection was performed and fifty-five clones were found to contain sequences that were not previously reported as known genes or ESTs. These clones and polymorphisms will assist in the further characterization of this region and identification of disease genes.
|
|
| 4. |
- Glassman, A. H., et al.
(författare)
-
Sertraline treatment of major depression in patients with acute MI or unstable angina
- 2002
-
Ingår i: JAMA. - 0098-7484. ; 288:6, s. 701-9
-
Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: Major depressive disorder (MDD) occurs in 15% to 23% of patients with acute coronary syndromes and constitutes an independent risk factor for morbidity and mortality. However, no published evidence exists that antidepressant drugs are safe or efficacious in patients with unstable ischemic heart disease. OBJECTIVE: To evaluate the safety and efficacy of sertraline treatment of MDD in patients hospitalized for acute myocardial infarction (MI) or unstable angina and free of other life-threatening medical conditions. DESIGN AND SETTING: Randomized, double-blind, placebo-controlled trial conducted in 40 outpatient cardiology centers and psychiatry clinics in the United States, Europe, Canada, and Australia. Enrollment began in April 1997 and follow-up ended in April 2001. PATIENTS: A total of 369 patients with MDD (64% male; mean age, 57.1 years; mean 17-item Hamilton Depression [HAM-D] score, 19.6; MI, 74%; unstable angina, 26%). INTERVENTION: After a 2-week single-blind placebo run-in, patients were randomly assigned to receive sertraline in flexible dosages of 50 to 200 mg/d (n = 186) or placebo (n = 183) for 24 weeks. MAIN OUTCOME MEASURES: The primary (safety) outcome measure was change from baseline in left ventricular ejection fraction (LVEF); secondary measures included surrogate cardiac measures and cardiovascular adverse events, as well as scores on the HAM-D scale and Clinical Global Impression Improvement scale (CGI-I) in the total randomized sample, in a group with any prior history of MDD, and in a more severe MDD subgroup defined a priori by a HAM-D score of at least 18 and history of 2 or more prior episodes of MDD. RESULTS: Sertraline had no significant effect on mean (SD) LVEF (sertraline: baseline, 54% [10%]; week 16, 54% [11%]; placebo: baseline, 52% [13%]; week 16, 53% [13%]), treatment-emergent increase in ventricular premature complex (VPC) runs (sertraline: 13.1%; placebo: 12.9%), QTc interval greater than 450 milliseconds at end point (sertraline: 12%; placebo: 13%), or other cardiac measures. All comparisons were statistically nonsignificant (P> or = .05). The incidence of severe cardiovascular adverse events was 14.5% with sertraline and 22.4% with placebo. In the total randomized sample, the CGI-I (P =.049), but not the HAM-D (P =.14), favored sertraline. The CGI-I responder rates for sertraline were significantly higher than for placebo in the total sample (67% vs 53%; P =.01), in the group with at least 1 prior episode of depression (72% vs 51%; P =.003), and in the more severe MDD group (78% vs 45%; P =.001). In the latter 2 groups, both CGI-I and HAM-D measures were significantly better in those assigned to sertraline. CONCLUSION: Our results suggest that sertraline is a safe and effective treatment for recurrent depression in patients with recent MI or unstable angina and without other life-threatening medical conditions.
|
|
| 5. |
- Johansson, Jan, 1960, et al.
(författare)
-
Continuous GPS measurements of postglacial adjustment in Fennoscandia - 1. Geodetic results
- 2002
-
Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 107:B8
-
Tidskriftsartikel (refereegranskat)abstract
- Project BIFROST (Baseline Inferences for Fennoscandian Rebound Observations, Sea-level, and Tectonics) combines networks of continuously operating GPS receivers in Sweden and Finland to measure ongoing crustal deformation due to glacial isostatic adjustment (GIA). We present an analysis of data collected between August 1993 and May 2000. We compare the GPS determinations of three-dimensional crustal motion to predictions calculated using the high-resolution Fennoscandian deglaciation model recently proposed by Lambeck et al. [1998a, 1998b]. We find that the maximum observed uplift rate (~10 mm/yr) and the maximum predicted uplift rate agree to better than 1 mm yr-1. The patterns of uplift also agree quite well, although significant systematic differences are evident. The root-mean-square residual rate for a linear error model yields estimates of rate accuracy of 0.4 mm/yr for east, 0.3 mm/yr for north, and 1.3 mm/yr for up; these figures incorporate model errors, however. We have also compared the values for the observed radial deformation rates to those based on sea level rates from Baltic tide gauges. The observational error for the vertical GPS rates required to give a reduced chi^2 of unity is 0.8 mm/yr. The time series do exhibit temporal variations at seasonal frequencies, as well as apparent low-frequency noise. An empirical orthogonal function analysis indicates that the temporal variations are highly correlated among the sites. The correlation appears to be regional and falls off only slightly with distance. Some of this correlated noise is associated with snow accumulation on the antennas or, for those antennas with radomes, on the radomes. This problem has caused us to modify the radomes used several times, leading to one of our more significant sources of uncertainty.
|
|
| 6. |
|
|
| 7. |
- Perez-Torres, M. A., et al.
(författare)
-
High-resolution radio imaging of young supernovae
- 2004
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The high resolution obtained through the use of VLBI gives an unique opportunity to directly observe the interaction of an expanding radio supernova with its surrounding medium. We present here results from our VLBI observations of the young supernovae SN 1979C, SN 1986J, and SN 2001gd.
|
|
