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Numrering	Referens	Omslagsbild	Hitta
1.	Kennedy, RD, et al. (författare) Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue 2011 Ingår i: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755. ; 29:35, s. 4620-4626 Tidskriftsartikel (refereegranskat)
2.	Gremel, G., et al. (författare) Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma 2011 Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 105:4, s. 565-574 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: The homeobox containing transcription factor MSX2 is a key regulator of embryonic development and has been implicated to have a role in breast and pancreatic cancer. METHODS: Using a selection of two-and three-dimensional in vitro assays and tissue microarrays (TMAs), the clinical and functional relevance of MSX2 in malignant melanoma was explored. A doxycyline-inducible over-expression system was applied to study the relevance of MSX2 in vitro. For TMA construction, tumour material from 218 melanoma patients was used. RESULTS: Ectopic expression of MSX2 resulted in the induction of apoptosis and reduced the invasive capacity of melanoma cells in three-dimensional culture. MSX2 over-expression was shown to affect several signalling pathways associated with cell invasion and survival. Downregulation of N-Cadherin, induction of p21 and inhibition of both BCL2 and Survivin were observed. Cytoplasmic MSX2 expression was found to correlate significantly with increased recurrence-free survival (P = 0.008). Nuclear expression of MSX2 did not result in significant survival correlations, suggesting that the beneficial effect of MSX2 may be independent of its DNA binding activity. CONCLUSIONS: MSX2 may be an important regulator of melanoma cell invasion and survival. Cytoplasmic expression of the protein was identified as biomarker for good prognosis in malignant melanoma patients.

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Sheahan, K. (2); Pontén, Fredrik (1); Winter, A (1); O'Brien, E (1); Winqvist, O (1); Marshall, J (1); visa fler...; Wilson, C (1); O'Donoghue, D (1); Oliver, G. (1); Ramaswamy, S (1); Joyce, C (1); Ryan, D. (1); Holt, RJ (1); Lavelle, M. (1); Gallagher, W. M. (1); McDermott, U (1); Bathe, OF (1); Dhir, R (1); Johnston, PG (1); Bylesjo, M (1); Sargent, DJ (1); Gremel, G. (1); Rafferty, M. (1); Lanigan, F. (1); Hegarty, S. (1); Murphy, I. (1); Unwin, L. (1); Faller, W. (1); McDermott, E. W. (1); O'Sullivan, J. (1); Kennedy, RD (1); Kerr, P (1); Davison, T (1); Black, JM (1); Kay, EW (1); Proutski, V (1); Ahdesmaki, M (1); Farztdinov, V (1); Goffard, N (1); Hey, P (1); McDyer, F (1); Mulligan, K (1); Mussen, J (1); Walker, SM (1); Mulligan, JM (1); Mulcahy, H (1); Hyland, J (1); Manne, U (1); Shanmugam, C (1); Leon, EJ (1); visa färre...

Lärosäte: Uppsala universitet (1); Karolinska Institutet (1)

Språk: Engelska (2)

År: 2011 (2)

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