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Proteomic profiling...
Proteomic profiling reveals novel biomarkers and pathways in yype 2 diabetes risk
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- Ngo, Debby (författare)
- Beth Israel Deaconess Medical Center
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- Benson, Mark D (författare)
- Beth Israel Deaconess Medical Center
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- Long, Jonathan Z (författare)
- Stanford University
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- Chen, Zsu-Zsu (författare)
- Beth Israel Deaconess Medical Center
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- Wang, Ruiqi (författare)
- Boston University
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- Nath, Anjali K (författare)
- Beth Israel Deaconess Medical Center
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- Keyes, Michelle J (författare)
- Beth Israel Deaconess Medical Center
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- Shen, Dongxiao (författare)
- Beth Israel Deaconess Medical Center
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- Sinha, Sumita (författare)
- Beth Israel Deaconess Medical Center
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- Kuhn, Eric (författare)
- Broad Institute
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- Morningstar, Jordan E (författare)
- Beth Israel Deaconess Medical Center
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- Shi, Xu (författare)
- Beth Israel Deaconess Medical Center
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- Peterson, Bennet D (författare)
- Beth Israel Deaconess Medical Center
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- Chan, Christopher (författare)
- Beth Israel Deaconess Medical Center
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- Katz, Daniel H (författare)
- Beth Israel Deaconess Medical Center
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- Tahir, Usman A (författare)
- Beth Israel Deaconess Medical Center
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- Farrell, Laurie A (författare)
- Beth Israel Deaconess Medical Center
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Mosley, Jonathan D (författare)
- Vanderbilt University Medical Center
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- Carr, Steven A (författare)
- Broad Institute
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- Vasan, Ramachandran S (författare)
- National Heart Lung and Blood Institute,Boston University
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- Larson, Martin G (författare)
- Boston University,National Heart Lung and Blood Institute
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- Smith, J Gustav (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Epigenetics,WCMM- Wallenberg center för molekylär medicinsk forskning,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Sahlgrenska University Hospital
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- Wang, Thomas J (författare)
- University of Texas Southwestern Medical Center
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- Yang, Qiong (författare)
- Beth Israel Deaconess Medical Center
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- Gerszten, Robert E (författare)
- Broad Institute,Beth Israel Deaconess Medical Center
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(creator_code:org_t)
- 2021-03-08
- 2021
- Engelska.
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Ingår i: JCI Insight. - : American Society for Clinical Investigation. - 2379-3708. ; 6:5
- Relaterad länk:
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http://dx.doi.org/10...
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http://insight.jci.o...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Recent advances in proteomic technologies have made high throughput profiling of low abundance proteins in large epidemiological cohorts increasingly feasible. We investigated whether aptamer-based proteomic profiling could identify biomarkers associated with future development of type 2 diabetes (T2DM) beyond known risk factors. We identified dozens of markers with highly significant associations with future T2DM across two large longitudinal cohorts (n=2,839) followed for up to 16 years. We leveraged proteomic, metabolomic, genetic and clinical data from humans to nominate one specific candidate to test for potential causal relationships in model systems. Our studies identified functional effects of aminoacylase 1 (ACY1), a top protein association with future T2DM risk, on amino acid metabolism and insulin homeostasis in vitro and in vivo. Further, a loss-of-function variant associated with circulating levels of the biomarker WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 (WFIKKN2) was in turn associated with fasting glucose, hemoglobin A1c and HOMA-IR measurements in humans. In addition to identifying novel disease markers and potential pathways in T2DM, we provide publicly available data to be leveraged for new insights about gene function and disease pathogenesis in the context of human metabolism. .
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ngo, Debby
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Benson, Mark D
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Long, Jonathan Z
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Chen, Zsu-Zsu
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Wang, Ruiqi
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Nath, Anjali K
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Keyes, Michelle ...
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Shen, Dongxiao
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Sinha, Sumita
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Kuhn, Eric
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Morningstar, Jor ...
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Shi, Xu
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Peterson, Bennet ...
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Chan, Christophe ...
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Katz, Daniel H
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Tahir, Usman A
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Farrell, Laurie ...
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Melander, Olle
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Mosley, Jonathan ...
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Carr, Steven A
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Vasan, Ramachand ...
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Larson, Martin G
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Smith, J Gustav
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Wang, Thomas J
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Yang, Qiong
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Gerszten, Robert ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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JCI Insight
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Lunds universitet