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Major Histocompatib...
Major Histocompatibility Complex Variation and Haplotype Associated Survival in Response to Experimental Infection of Two Bd-GPL Strains Along a Latitudinal Gradient
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- Cortazar-Chinarro, Maria (författare)
- Uppsala University,Lund University,Lunds universitet,Uppsala universitet,Zooekologi,Lund Univ, Fac Sci, Dept Biol, MEMEG, Lund, Sweden.;Univ British Columbia, Fac Sci, Dept Earth Ocean & Atmospher Sci, Vancouver, BC, Canada.,MEMEG,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science,University of British Columbia
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- Meurling, Sara (författare)
- Uppsala University,Uppsala universitet,Zooekologi
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- Schroyens, Laurens (författare)
- Uppsala University,Uppsala universitet,Zooekologi
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- Siljestam, Mattias, 1989- (författare)
- Uppsala University,Uppsala universitet,Zooekologi
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- Richter-Boix, Alex (författare)
- Pompeu Fabra Univ, Dept Polit & Social Sci, Barcelona, Spain.,Pompeu Fabra University
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- Laurila, Anssi (författare)
- Uppsala University,Uppsala universitet,Zooekologi
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- Höglund, Jacob (författare)
- Uppsala University,Uppsala universitet,Zooekologi
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(creator_code:org_t)
- 2022-07-04
- 2022
- Engelska.
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Ingår i: Frontiers in Ecology and Evolution. - : Frontiers Media S.A.. - 2296-701X. ; 10
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- While both innate and adaptive immune system mechanisms have been implicated in resistance against the chytrid fungus Batrachochytrium dendrobatidis (Bd), studies on the role of specific MHC haplotypes on Bd infection are rare. Here, we studied variation in MHC Class IIB loci in the common toad Bufo bufo along a latitudinal gradient across Sweden. In general, Swedish toad populations had few MHC Class IIB haplotypes and MHC diversity declined from south (13 haplotypes) to the north (four haplotypes). The low diversity may compromise the ability of northern populations to fight emerging disease, such as Bd. In a laboratory experiment, we infected newly metamorphosed toads with two strains of the Global Pandemic Lineage of the fungus (Bd-GPL) and compared survival with sham controls. Bd-infected toads had lower survival compared to controls. Moreover, survival was dependent on the Bd-strain and northern toads had lower Bd-mediated survival than southern individuals. MHC diversity was lower in northern toads. All northern experimental animals were monomorphic for a single MHC haplotype, whereas we found seven different haplotypes in southern experimental animals. In southern toads, survival was dependent on both Bd-strain and MHC haplotype suggesting differential infection dynamics depending on both Bd-strain and host immune system characteristics.
Ämnesord
- NATURVETENSKAP -- Biologi -- Ekologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Ecology (hsv//eng)
Nyckelord
- MHC
- infection
- disease
- amphibian
- chytrid fungus
- Bufo bufo
- amphibian
- Bufo bufo
- chytrid fungus
- disease
- infection
- MHC
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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