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Träfflista för sökning "WFRF:(Skene N. G.) srt2:(2018)"

Sökning: WFRF:(Skene N. G.) > (2018)

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Numrering	Referens	Omslagsbild	Hitta
1.	Savage, J. E., et al. (författare) Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence 2018 Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 50:7, s. 912-919 Tidskriftsartikel (refereegranskat)abstract Intelligence is highly heritable 1 and a major determinant of human health and well-being 2 . Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence 3-7, but much about its genetic underpinnings remains to be discovered. Here, we present a large-scale genetic association study of intelligence (n = 269,867), identifying 205 associated genomic loci (190 new) and 1,016 genes (939 new) via positional mapping, expression quantitative trait locus (eQTL) mapping, chromatin interaction mapping, and gene-based association analysis. We find enrichment of genetic effects in conserved and coding regions and associations with 146 nonsynonymous exonic variants. Associated genes are strongly expressed in the brain, specifically in striatal medium spiny neurons and hippocampal pyramidal neurons. Gene set analyses implicate pathways related to nervous system development and synaptic structure. We confirm previous strong genetic correlations with multiple health-related outcomes, and Mendelian randomization analysis results suggest protective effects of intelligence for Alzheimer's disease and ADHD and bidirectional causation with pleiotropic effects for schizophrenia. These results are a major step forward in understanding the neurobiology of cognitive function as well as genetically related neurological and psychiatric disorders.
2.	Savage, JE, et al. (författare) GWAS meta-analysis (N=279,930) identifies new genes and functional links to general cognitive ability 2018 Ingår i: HUMAN GENOMICS. - 1473-9542. ; 12 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
3.	Zhu, Fei, et al. (författare) Architecture of the Mouse Brain Synaptome 2018 Ingår i: Neuron. - : CELL PRESS. - 0896-6273 .- 1097-4199. ; 99:4, s. 781- Tidskriftsartikel (refereegranskat)abstract Synapses are found in vast numbers in the brain and contain complex proteomes. We developed genetic labeling and imaging methods to examine synaptic proteins in individual excitatory synapses across all regions of the mouse brain. Synapse catalogs were generated from the molecular and morphological features of a billion synapses. Each synapse subtype showed a unique anatomical distribution, and each brain region showed a distinct signature of synapse subtypes. Whole-brain synaptome cartography revealed spatial architecture from dendritic to global systems levels and previously unknown anatomical features. Synaptome mapping of circuits showed correspondence between synapse diversity and structural and functional connectomes. Behaviorally relevant patterns of neuronal activity trigger spatio-temporal postsynaptic responses sensitive to the structure of synaptome maps. Areas controlling higher cognitive function contain the greatest synapse diversity, and mutations causing cognitive disorders reorganized synaptome maps. Synaptome technology and resources have wide-ranging application in studies of the normal and diseased brain.
4.	Zeisel, A, et al. (författare) Molecular Architecture of the Mouse Nervous System 2018 Ingår i: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 174:4, s. 999- Tidskriftsartikel (refereegranskat)

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Resultat 1-4 av 4

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Typ av publikation: tidskriftsartikel (3); konferensbidrag (1)

Typ av innehåll: refereegranskat (3); övrigt vetenskapligt/konstnärligt (1)

Författare/redaktör: Linnarsson, S (3); Hjerling-Leffler, J (3); Nagel, M. (2); Yu, J. (2); Davies, G (2); Plomin, R (2); visa fler...; Watanabe, K. (2); Melle, I (2); Djurovic, S (2); Tiemeier, H (2); Breen, G (2); Abecasis, G (2); Corvin, A (2); Rujescu, D (2); Donohoe, G (2); Espeseth, T (2); Heinz, A (2); Le Hellard, S (2); White, T (2); Schumann, G (2); Ripke, S (2); Lahti, J (2); Zabaneh, D. (2); Palotie, A (2); Roussos, P (2); Widen, E (2); Morris, D. (2); Karlsson, R (2); Gill, M. (2); Bryois, J (2); Posthuma, D (2); Christoforou, A. (2); Reinvang, I. (2); Sundet, K. (2); Krapohl, E. (2); Nygaard, M. (2); Debrabant, B. (2); Christiansen, L. (2); Giegling, I (2); Young, H (2); Konte, B. (2); Lencz, T. (2); Awasthi, S. (2); Dickinson, D. (2); Skene, N (2); Avramopoulos, D (2); Pendleton, N. (2); Hatzimanolis, A. (2); Payton, A (2); Chiba-Falek, O (2); visa färre...

Lärosäte: Karolinska Institutet (4); Kungliga Tekniska Högskolan (1); Jönköping University (1)

Språk: Engelska (4)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

År: 2018 (4)Ta bort avgränsningen

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