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Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Steinthorsdottir, V (author)
deCODE Genetics
McGinnis, R (author)
Williams, NO (author)
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Stefansdottir, L (author)
Thorleifsson, G (author)
Shooter, S (author)
Karolinska Institutet
Fadista, Joao (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Danish Serum Institute, Copenhagen
Sigurdsson, JK (author)
Karolinska Institutet
Auro, KM (author)
Berezina, G (author)
Borges, MC (author)
Bumpstead, S (author)
Bybjerg-Grauholm, J (author)
Colgiu, I (author)
Dolby, VA (author)
Dudbridge, F (author)
Engel, SM (author)
Franklin, CS (author)
Frigge, ML (author)
University of Nottingham
Frisbaek, Y (author)
Geirsson, RT (author)
Geller, F (author)
Gretarsdottir, S (author)
Gudbjartsson, DF (author)
Harmon, Q (author)
Hougaard, DM (author)
Hegay, T (author)
Helgadottir, A (author)
Hjartardottir, S (author)
Jaaskelainen, T (author)
Johannsdottir, H (author)
Jonsdottir, I (author)
Juliusdottir, T (author)
Kalsheker, N (author)
Kasimov, A (author)
Kemp, JP (author)
Kivinen, K (author)
Klungsoyr, K (author)
Lee, WK (author)
Melbye, M (author)
Miedzybrodska, Z (author)
Moffett, A (author)
Najmutdinova, D (author)
Nishanova, F (author)
Olafsdottir, T (author)
Perola, M (author)
Pipkin, FB (author)
Poston, L (author)
Prescott, G (author)
Saevarsdottir, S (author)
Karolinska Institutet
Salimbayeva, D (author)
Scaife, PJ (author)
Skotte, L (author)
Staines-Urias, E (author)
Stefansson, OA (author)
Sorensen, KM (author)
Thomsen, LCV (author)
Tragante, V (author)
Trogstad, L (author)
Simpson, NAB (author)
Laivuori, H (author)
Morgan, L (author)
Aripova, T (author)
Casas, JP (author)
Dominiczak, AF (author)
Walker, JJ (author)
Thorsteinsdottir, U (author)
Iversen, AC (author)
Feenstra, B (author)
Lawlor, DA (author)
Boyd, HA (author)
Magnus, P (author)
Laivuori, H (author)
Zakhidova, N (author)
Svyatova, G (author)
Stefansson, K (author)
Morgan, L (author)
Laivuori, H (author)
Heinonen, S (author)
Kajantie, E (author)
Kere, J (author)
Karolinska Institutet
Kivinen, K (author)
Pouta, A (author)
Morgan, L (author)
Pipkin, FB (author)
Kalsheker, N (author)
Walker, JJ (author)
Macphail, S (author)
Kilby, M (author)
Habiba, M (author)
Williamson, C (author)
O'Shaughnessy, K (author)
O'Brien, S (author)
Cameron, A (author)
Redman, CWG (author)
Farrall, M (author)
Caulfield, M (author)
Dominiczak, AF (author)
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 (creator_code:org_t)
2020-11-25
2020
English.
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 5976-
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Keyword

blood
body mass
genome
meta-analysis
public health
risk assessment

Publication and Content Type

ref (subject category)
art (subject category)

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