SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Smedby K) "

Search: WFRF:(Smedby K)

  • Result 1-10 of 161
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Cozen, W., et al. (author)
  • A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus
  • 2014
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5, s. 3856-
  • Journal article (peer-reviewed)abstract
    • Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR) = 0.81, 95% confidence interval (95% CI) = 0.76-0.86, P-combined 3.5 x 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B-and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.
  •  
2.
  •  
3.
  •  
4.
  • Sampson, Joshua N., et al. (author)
  • Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
  • 2015
  • In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 107:12
  • Journal article (peer-reviewed)abstract
    • Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-10 of 161
Type of publication
journal article (123)
conference paper (24)
other publication (10)
reports (2)
research review (1)
book chapter (1)
show more...
show less...
Type of content
peer-reviewed (111)
other academic/artistic (50)
Author/Editor
Smedby, KE (42)
Smedby, K E (42)
Smedby, Karin E. (22)
Glimelius, Bengt (21)
Hjalgrim, H (20)
Pospisilova, S (17)
show more...
Ghia, P (17)
Smedby, B (17)
Rosenquist, R. (16)
Davis, Z (16)
Hjalgrim, Henrik (16)
Eloranta, S (16)
Adami, Hans Olov (15)
Melbye, Mads (15)
Bracci, Paige M (15)
Conde, Lucia (15)
Skibola, Christine F ... (15)
Cerhan, James R. (15)
Stamatopoulos, K (14)
Oscier, D. (14)
Spinelli, John J. (14)
Rothman, Nathaniel (14)
Lan, Qing (14)
Cozen, Wendy (14)
Purdue, Mark P. (14)
Chanock, Stephen J (13)
Juliusson, G (13)
Brennan, Paul (13)
Foretova, Lenka (13)
Becker, Nikolaus (13)
Askling, J (13)
Benavente, Yolanda (13)
Link, Brian K. (13)
Maynadie, Marc (13)
Morton, Lindsay M. (13)
Nieters, Alexandra (13)
Mansouri, Larry (12)
Berndt, Sonja I (12)
Giles, Graham G (12)
Scarfo, L (12)
Boffetta, Paolo (12)
Offit, Kenneth (12)
Teras, Lauren R. (12)
Wang, Sophia S. (12)
Birmann, Brenda M. (12)
Brooks-Wilson, Angel ... (12)
Clavel, Jacqueline (12)
de Sanjose, Silvia (12)
Monnereau, Alain (12)
Severson, Richard K. (12)
show less...
University
Karolinska Institutet (124)
Uppsala University (87)
Lund University (26)
Linköping University (15)
University of Gothenburg (9)
Umeå University (7)
show more...
Royal Institute of Technology (7)
Örebro University (5)
show less...
Language
English (155)
Swedish (6)
Research subject (UKÄ/SCB)
Medical and Health Sciences (85)
Engineering and Technology (5)
Natural sciences (1)
Social Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view