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Träfflista för sökning "WFRF:(Smith Matt 1971 ) srt2:(2020)"

Sökning: WFRF:(Smith Matt 1971 ) > (2020)

  • Resultat 1-4 av 4
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1.
  • Surendran, Praveen, et al. (författare)
  • Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
  • 2020
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 52:12, s. 1314-1332
  • Tidskriftsartikel (refereegranskat)abstract
    • Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency <= 0.01) variant BP associations (P < 5 x 10(-8)), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were similar to 8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets.
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2.
  • Smith, Matt, 1971- (konstnär, creator_code:cre_t)
  • Losing Venus
  • 2020
  • Konstnärligt arbete (refereegranskat)abstract
    • Losing Venus, consisting of multiple installations by artist Matt Smith, highlights the colonial impact on LGBTQ+ lives across the British Empire and seeks to make queer lives physically manifest within the museum. From 1860 onwards, the British Empire criminalized male-to-male relations, imposing lengthy prison sentences, and the legacy of these legal codes lives on. Of the 72 countries in the world with anti-gay laws, 38 of them were once subject to British colonial rule. As a response to these colonialist gender laws, Losing Venus seeks to place contemporary discrimination, which is still affecting the lives of many around the world, at the heart of one of the cultural centres of the country which exported it, examining their impact through the lens of sexual identity and gender fluidity.The title Losing Venus is a reference to the idea of love and gender, but also references the purpose of Captain Cook’s first voyage – to measure the transit of the planet Venus. The installation comprises four main parts located on the Lower Gallery (first floor) of the Pitt Rivers Museum.
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3.
  • Smith, Matt, 1971- (författare)
  • Losing Venus
  • 2020
  • Ingår i: Losing Venus. - Oxford : Pitt Rivers Museum. ; , s. 15-22
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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4.
  • Smith, Matt, 1971- (författare)
  • Remolding the Museum :
  • 2020
  • Ingår i: Museums, Sexuality, and Gender Activism. - : Routledge. - 9780367195106 ; , s. 69-78
  • Bokkapitel (refereegranskat)
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  • Resultat 1-4 av 4

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