| 1. |
- Adam, M., et al.
(författare)
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Hydroxysteroid (17 beta) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice
- 2018
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Ingår i: Faseb Journal. - 0892-6638. ; 32:6, s. 3434-3447
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Tidskriftsartikel (refereegranskat)abstract
- Hydroxysteroid (17(3) dehydrogenases (HSD17Bs) form an enzyme family characterized by their ability to catalyze reactions in steroid and lipid metabolism. In the present study, we characterized the phenotype of HSD17B13-knockout (HSD17B13KO) mice deficient in Hsd1 7b13. In these studies, hepatic steatosis was detected in HSD17B13KO male mice, indicated by histologic analysis and by the increased triglyceride concentration in the liver, whereas reproductive performance and serum steroid concentrations were normal in HSD17B13KO mice. In line with these changes, the expression of key proteins in fatty acid synthesis, such as FAS, acetyl-CoA carboxylase 1, and SCD1, was increased in the HSD17B13KO liver. Furthermore, the knockout liver showed an increase in 2 acylcamitines, suggesting impaired mitochondrial beta-oxidation in the presence of unaltered malonyl CoA and AMPK expression. The glucose tolerance did not differ between wild-type and HSD17B13KO mice in the presence of lower levels of glucose 6-phosphatase in HSD17B13KO liver compared with wild-type liver. Furthermore, microgranulomas and increased portal inflammation together with up-regulation of immune response genes were observed in HSD17B13KO mice. Our data indicate that disruption of Hsdl7b13 impairs hepatic-lipid metabolism in mice, resulting in liver steatosis and inflammation, but the enzyme does not play a major role in the regulation of reproductive functions.
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| 2. |
- Arpaia, Riccardo, 1985, et al.
(författare)
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High-temperature superconducting nanowires for photon detection
- 2015
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Ingår i: Physica C: Superconductivity and its Applications. - : Elsevier BV. - 0921-4534. ; 509, s. 16-21
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Tidskriftsartikel (refereegranskat)abstract
- The possible use of high-temperature superconductors (HTS) for realizing superconducting nanowire single-photon detectors is a challenging, but also promising, aim because of their ultrafast electron relaxation times and high operating temperatures. The state-of-the-art HTS nanowires with a 50-nm thickness and widths down to 130 nm have been fabricated and tested under a 1550-nm wavelength laser irradiation. Experimental results presenting both the amplitude and rise times of the photoresponse signals as a function of the normalized detector bias current, measured in a wide temperature range, are discussed. The presence of two distinct regimes in the photoresponse temperature dependence is clearly evidenced, indicating that there are two different response mechanisms responsible for the HTS photoresponse mechanisms.
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| 3. |
- Parlato, L., et al.
(författare)
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Investigation of dark counts in innovative materials for superconducting nanowire single-photon detector applications
- 2017
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. - 9781510609594 ; 10229, s. Article no 102290I-
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Konferensbidrag (refereegranskat)abstract
- The phenomenon of dark counts in nanostripes of different superconductor systems such as high-temperature superconducting YBa 2 Cu 3 O 7-x and superconductor/ferromagnet hybrids consisting of either NbN/NiCu or YBa 2 Cu 3 O 7-x /L 0.7 Sr 0.3 MnO 3 bilayers have been investigated. For NbN/NiCu the rate of dark-count transients have been reduced with respect to pure NbN nanostripes and the events were dominated by a single vortex entry from the edge of the stripe. In the case of nanostripes based on YBa 2 Cu 3 O 7-x , we have found that thermal activation of vortices was also, apparently, responsible for triggering dark-count signals.
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| 4. |
- Pepe, G. P., et al.
(författare)
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Y-Ba-Cu-O Nanostripes for Optical Photon Detection
- 2015
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. - 9781628416251 ; 9504
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Konferensbidrag (refereegranskat)abstract
- Nanowires of Y-Ba-Cu-O, with the thickness of 50 nm and the width ranging from 90 nm to 500 nm have been successfully grown on lanthanum aluminate substrates for photon detection experiments. The nanowires were up to 10-mu m long and formed a meander structure, covering the area of up to 30x10 mu m(2) with a fill factor of 50%. The samples were excited using optical laser pulses at a 1550 nm wavelength and resulting photoresponse signals were measured as a function of both temperature and normalized bias current. Presence of two, distinct regimes in the photoresponse temperature dependence has been clearly evidenced, suggesting different physical mechanisms of the signal formation. Presented experimental results shed new light on prospects of implementation of high-temperature superconducting oxides in photon detection and counting.
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