| 1. |
- Andersson, Viktor, et al.
(författare)
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Morphology of organic electronic materials imaged via electron tomography
- 2012
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Ingår i: Journal of Microscopy. - : Wiley. - 0022-2720 .- 1365-2818. ; 247:3, s. 277-287
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Tidskriftsartikel (refereegranskat)abstract
- Several organic materials and blends have been studied with the use of electron tomography. Tomography reconstructions of active layers of organic solar cells, where various preparation techniques have been used, have been analysed and compared to device behaviour. In addition, materials with predefined structures, including contrast enhancing features, have been studied and double tilt data collection has been employed to improve reconstructions. Small changes in preparation procedures may lead to large differences in morphology and device performance, and the results also indicate a complex relation between these.
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| 2. |
- Andersson, Viktor, et al.
(författare)
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Preparation of amyloidlike fibrils containing magnetic iron oxide nanoparticles: Effect of protein aggregation on proton relaxivity
- 2012
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Ingår i: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier. - 0006-291X .- 1090-2104. ; 419:4, s. 682-686
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Tidskriftsartikel (refereegranskat)abstract
- A method to prepare amyloid-like fibrils functionalized with magnetic nanoparticles has been developed. The amyloid-like fibrils are prepared in a two step procedure, where insulin and magnetic nanoparticles are mixed simply by grinding in the solid state, resulting in a water soluble hybrid material. When the hybrid material is heated in aqueous acid, the insulin/nanoparticle hybrid material self assembles to form amyloid-like fibrils incorporating the magnetic nanoparticles. This results in magnetically labeled amyloid-like fibrils which has been characterized by Transmission Electron Microscopy (TEM) and electron tomography. The influence of the aggregation process on proton relaxivity is investigated. The prepared materials have potential uses in a range of bio-imaging applications.
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| 3. |
- Bäcklund, Fredrik, et al.
(författare)
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Amyloid fibrils as dispersing agents for oligothiophenes: control of photophysical properties through nanoscale templating and flow induced fibril alignment
- 2014
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Ingår i: Journal of Materials Chemistry. - : Royal Society of Chemistry (RSC). - 1364-5501 .- 0959-9428 .- 2050-7526 .- 2050-7534. ; 2:37, s. 7811-7822
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Tidskriftsartikel (refereegranskat)abstract
- Herein we report that protein fibrils formed from aggregated proteins, so called amyloid fibrils, serve as an excellent dispersing agent for hydrophobic oligothiophenes such as alpha-sexithiophene (6T). Furthermore, the protein fibrils are capable of orienting 6T along the fibril long axis, as demonstrated by flow-aligned linear dichroism spectroscopy and polarized fluorescence microscopy. The materials are prepared by solid state mixing of 6T with a protein capable of self-assembly. This results in a water soluble composite material that upon heating in aqueous acid undergoes self-assembly into protein fibrils non-covalently functionalized with 6T, with a typical diameter of 5-10 nm and lengths in the micrometre range. The resulting aqueous fibril dispersions are a readily available source of oligothiophenes that can be processed from aqueous solvent, and we demonstrate the fabrication of macroscopic structures consisting of aligned 6T functionalized protein fibrils. Due to the fibril induced ordering of 6T these structures exhibit polarized light emission.
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| 4. |
- Bäcklund, Fredrik, et al.
(författare)
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Development and Application of Methodology for Rapid Screening of Potential Amyloid Probes
- 2014
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Ingår i: ACS COMBINATORIAL SCIENCE. - : ACS Publications. - 2156-8952 .- 2156-8944. ; 16:12, s. 721-729
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Tidskriftsartikel (refereegranskat)abstract
- Herein, we demonstrate that it is possible to rapidly screen hydrophobic fluorescent aromatic molecules with regards to their properties as amyloid probes. By grinding the hydrophobic molecule with the amyloidogenic protein insulin, we obtained a water-soluble composite material. When this material is dissolved and exposed to conditions promoting amyloid formation, the protein aggregates into amyloid fibrils incorporating the hydrophobic molecule. As a result, changes in the fluorescence spectra of the hydrophobic molecule can be correlated to the formation of amyloid fibrils, and the suitability of the hydrophobic molecular skeleton as an amyloid probe can thus be assessed. As a result, we discovered two new amyloid probes, of which one is the well-known laser dye DCM. The grinding method can also be used for rapid preparation of novel composite materials between dyes and proteins, which can be used in materials science applications such as organic electronics and photonics.
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| 5. |
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| 6. |
- Rizzo, Aurora, et al.
(författare)
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White Light with Phosphorescent Protein Fibrils in OLEDs
- 2010
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Ingår i: Nano Letters. - : American Chemical Society (ACS). - 1530-6992 .- 1530-6984. ; 10:6, s. 2225-2230
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Tidskriftsartikel (refereegranskat)abstract
- Red and yellow phosphorescent insulin amyloid fibrils are used as guest-emitting species within a blue-emitting polyfluorene matrix in light-emitting diodes. The integration of the phosphorescent Ir-complex into the amyloid structures strongly improves the triplet exciton confinement and allows the fabrication of white-emitting device with a very low loading of phosphorescent complex. The overall performances of the devices are improved in comparison with the corresponding bare Ir-complexes. This approach opens a way to explore novel device architectures and to understand the exciton/charge transfer dynamics in phosphorescent light emitting diodes.
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| 7. |
- Solin, Niclas, et al.
(författare)
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Preparation of amyloid-like materials functionalized with hydrophobic molecules
- 2011
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Ingår i: Abstracts of Papers of the American Chemical Society. - : American Chemical Society (ACS). - 0065-7727. ; 242, s. 526-ORGN-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- When exposed to acid and heat, insulin is known to self into fibril-like structures known as amyloid. These nanowires can be used as templates in materials science applications. We have developed methods that allow us to functionalize such nanowires with phosphorescent metal-complexes (Chem. Eur. J. 2010, 16, 4190). The method involves mixing the metal complex and the protein in the solid state, followed by self assembly of the resulting composite material. We were able to succesfully incorporate these materials into white OLEDs (Nano Lett. 2010, 10, 2225). We have now developed the method further to include various types of materials and molecules. We have also found that certain molecules might have dramatic effect on the self-assembly process, resulting in novel amyloid-based materials.
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| 8. |
- Solin, Niclas, et al.
(författare)
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Protein Nanofibrils Balance Colours in Organic White-Light-Emitting Diodes
- 2012
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Ingår i: Israel Journal of Chemistry. - : Wiley-VCH Verlag Berlin. - 0021-2148. ; 52:6, s. 529-539
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Forskningsöversikt (refereegranskat)abstract
- In this review we discuss our efforts in using protein nanowires (amyloid fibrils) as structural templates for use in organic electronics applications, mainly focusing on organic light-emitting diodes (OLEDs). We discuss different ways of functionalising amyloid fibrils. In one method, the amyloid fibril is used to organise luminescent polymers. We also discuss an alternative preparative method, resulting in amyloid-like materials functionalised with phosphorescent organometallic complexes. We discuss the incorporation of such materials in organic electronics devices, such as OLEDs. When amyloid fibrils are integrated into the OLED active layer, consisting of an electroluminescent blue-emitting polyfluorene, the efficiency of the device increases by a factor of 10. Furthermore, when amyloid fibrils incorporating phosphorescent metal complexes are used, the phosphorescent guest functions more efficiently than in the corresponding case where naked metal complexes are used. By preparing amyloid fibrils incorporating green- and red-emitting phosphorescent complexes, and combining these with blue-emitting polyfluorene, we can fabricate devices for white-light emission. The origin of the effects of the biomaterial on device performance is discussed.
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| 9. |
- Tang, Qun, et al.
(författare)
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Hybrid bioinorganic insulin amyloid fibrils
- 2010
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Ingår i: CHEMICAL COMMUNICATIONS. - : Royal Society of Chemistry. - 1359-7345 .- 1364-548X. ; 46:23, s. 4157-4159
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Tidskriftsartikel (refereegranskat)abstract
- Herein we report a method to functionalize in vitro grown insulin amyloid fibrils with various inorganic materials. The counterion of the positively charged amyloid fibril is exchanged with anions from various salts; subsequent addition of appropriate cations results in functionalization of the amyloid fibril. We demonstrate the formation of apatite and platinum complex structures ordered by the amyloid template.
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