| 1. |
- Du, Banghua, et al.
(författare)
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Energy management and performance analysis of an off-grid integrated hydrogen energy utilization system
- 2024
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Ingår i: Energy Conversion and Management. - 0196-8904. ; 299
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Tidskriftsartikel (refereegranskat)abstract
- In integrated hydrogen energy utilization systems, due to the low efficiency of hydrogen/electricity conversion, coordination of energy management and efficient waste heat recovery is required to optimize performance. To address this challenge, this paper presents a comprehensive and sophisticated modeling and energy management strategy to enhance the off-grid energy utilization rate while prolonging the main components' lifetime. The developed model incorporates multiphase flow and heat transport balance for electricity and heat production, enabling a highly accurate representation of real-world behaviors of the system. The proposed off-grid operation strategy is complemented by a designed heat recovery scheme, ensuring the use of energy resources and waste heat. In addition, the proposed energy management strategy monitors the real-time status of each subsystem, actively reducing the number of harmful start-stop cycles of the hydrogen production system, thereby mitigating short-term power impacts and delaying its aging. Specifically, the voltage degradation of the reduction cell is reduced from 4.67 mV to 4.48 mV, the energy utilization rate is increased from 47.6 % to 53.9 %, and the energy efficiency of fuel cells significantly increases from 53.6 % to 78.1 %.
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| 2. |
- Song, Jie, 1984-, et al.
(författare)
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The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
- 2022
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 82
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundTransforming growth factor β (TGFβ) is overexpressed in several advanced cancer types and promotes tumor progression. We have reported that the intracellular domain (ICD) of TGFβ receptor (TβR) I is cleaved by proteolytic enzymes in cancer cells, and then translocated to the nucleus in a manner dependent on the endosomal adaptor proteins APPL1/2, driving an invasiveness program. How cancer cells evade TGFβ-induced growth inhibition is unclear.MethodsWe performed microarray analysis to search for genes regulated by APPL1/2 proteins in castration-resistant prostate cancer (CRPC) cells. We investigated the role of TβRI and TRAF6 in mitosis in cancer cell lines cultured in 10% FBS in the absence of exogenous TGFβ. The molecular mechanism of the ubiquitination of AURKB by TRAF6 in mitosis and the formation of AURKB–TβRI complex in cancer cell lines and tissue microarrays was also studied.FindingsDuring mitosis and cytokinesis, AURKB–TβRI complexes formed in midbodies in CRPC and KELLY neuroblastoma cells. TRAF6 induced polyubiquitination of AURKB on K85 and K87, protruding on the surface of AURKB to facilitate its activation. AURKB–TβRI complexes in patient's tumor tissue sections correlated with the malignancy of prostate cancer.InterpretationThe AURKB–TβRI complex may become a prognostic biomarker for patients with risk of developing aggressive PC.
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| 3. |
- Thakur, Noopur, et al.
(författare)
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Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells
- 2020
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Ingår i: iScience. - : Cell Press. - 2589-0042. ; 23:9
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Tidskriftsartikel (refereegranskat)abstract
- Transforming growth factor β (TGF-β) enhances migration and invasion of cancer cells, causing life-threatening metastasis. Smad7 expression is induced by TGF-β to control TGF-β signaling in a negative feedback manner. Here we report an additional function of Smad7, i.e., to enhance TGF-β induction of c-Jun and HDAC6 via binding to their regulatory regions, promoting migration and invasion of prostate cancer cells. Lysine 102 in Smad7 is crucial for binding to specific consensus sites in c-Jun and HDAC6, even when endogenous Smad2, 3, and 4 were silenced by siRNA. A correlation between the mRNA expression of Smad7 and HDAC6, Smad7 and c-Jun, and c-Jun and HDAC6 was found in public databases from analyses of prostate cancer tissues. High expression of Smad7, HDAC6, and c-Jun correlated with poor prognosis for patients with prostate cancer. The knowledge that Smad7 can activate transcription of proinvasive genes leading to prostate cancer progression provides clinically relevant information.
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| 4. |
- Wan, Wenxin, et al.
(författare)
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Operating conditions combination analysis method of optimal water management state for PEM fuel cell
- 2023
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Ingår i: Green Energy and Intelligent Transportation. - 2773-1537 .- 2097-2512. ; 2:4
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Tidskriftsartikel (refereegranskat)abstract
- The water content of proton exchange membrane fuel cells (PEMFCs) affects the transport of reactants and the conductivity of the membrane. Effective water management measures can improve the performance and extend the lifespan of the fuel cell. The water management state of the stack is influenced by various external operating conditions, and optimizing the combination of these conditions can improve the water management state within the stack. Considering that the stack's internal resistance can reflect its water management state, this study first establishes an internal resistance-operating condition model that considers the coupling effect of temperature and humidity to determine the variation trend of total resistance and stack humidity with single-factor operating conditions. Subsequently, the water management state optimization method based on the ANN-HGPSO algorithm is proposed, which not only quantitatively evaluates the influence weights of different operating conditions on the stack's internal resistance but also efficiently and accurately obtains the optimal combination of five operating conditions: working temperature, anode gas pressure, cathode gas pressure, anode gas humidity, and cathode gas humidity to achieve the optimal water management state in the stack, within the entire range of current densities. Finally, the response surface experimental results of the stack also validate the effectiveness and accuracy of the ANN-HGPSO algorithm. The method mentioned in this article can provide effective strategies for efficient water management and output performance optimization control of PEMFC stacks.
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| 5. |
- Yu, Xiaoran, et al.
(författare)
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Remaining-useful-lifetime prediction of proton exchange membrane fuel cell considering model uncertainty quantification on the full-time scale
- 2023
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Ingår i: IEEE Transactions on Transportation Electrification. - 2332-7782. ; In Press
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Tidskriftsartikel (refereegranskat)abstract
- A prognostics and health management (PHM) system with prediction at its core optimizes the durability of the proton exchange membrane fuel cell (PEMFC). However, the aging behavior model has some uncertainty due to limited knowledge, affecting the predictive performance in remaining useful life (RUL) prediction. To address this issue, an RUL prediction method based on the Bayesian framework considering uncertainty quantification on the full-time scale is proposed. Firstly, the state of health (SOH) of the PEMFC is estimated, and the behavior of uncertainty is quantified. Afterwards, a long short-term memory (LSTM) neural network is employed to make a prediction for its behavior. Finally, the RUL of PEMFC is predicted based on historical SOH and the predicted behavior of uncertainty. Validation indicates that the proposed method can make a long-term prediction and provide RUL prediction with high accuracy. Under the dynamic operating condition, in terms of long-term prediction, compared to unscented Kalman filter, adaptive unscented Kalman filter, double-input-echo-state-network and bidirectional LSTM, the proposed method decreases the error by 88.12%, 41.99%, 13.82% and 3.21%, respectively. And under the dynamic operating condition, the proposed method shows good stability. Moreover, the robustness of this method has also been verified.
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