| 1. |
- Andrew, S, et al.
(författare)
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DNA analysis of distinct populations suggests multiple origins for the mutation causing Huntington disease.
- 1993
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Ingår i: Clinical Genetics. - 0009-9163 .- 1399-0004. ; 43:6, s. 286-94
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Tidskriftsartikel (refereegranskat)abstract
- Results of association studies can be significantly biased if the ancestry of the control population is not similar to that of the affected population. One approach to overcome such a bias is to use distinct populations where controls and affected individuals are likely to be of similar descent. We have examined homogeneous populations of French, Danish and Swedish ancestry for nonrandom allelic association between Huntington disease (HD) and several markers previously shown to be in association with HD. No evidence for nonrandom allelic association between HD and these markers was shown in these populations. The demonstration of association in a United Kingdom (UK) sample of similar size, and lack of significant differences in allele frequencies between the French, Danish, Swedish and UK populations suggested that the absence of association was not predominantly a consequence of allele frequencies or sample size. To investigate further the number of potential HD chromosomes, DNA haplotypes were constructed for the Danish, French, Swedish and UK populations. The minimum of two HD haplotypes observed in each of the French, Danish and Swedish populations, compared to the one haplotype in the UK population of a similar size, is an important factor accounting for the absence of association between HD and the DNA markers in these populations. Furthermore, these data are in favour of multiple independent origins for the mutation causing HD.
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| 2. |
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| 3. |
- Sorensen, S.L., et al.
(författare)
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A normal-incidence beam line at the MAX storage ring
- 1990
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - 0168-9002. ; 297:1-2, s. 296-300
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Tidskriftsartikel (refereegranskat)abstract
- A 1-m normal-incidence monochromator has been designed and installed on a bending-magnet beam line at the MAX storage ring in Lund. The optical properties of the beam line have been investigated via ray-tracing studies and with flux measurements of the beam line-monochromator combination. A resolution of 0.9 Å at 919.8 Å was measured in first-order diffraction with an argon hollow-cathode lamp for slit openings of 100 μm. A photon flux of 2.0 × 1010 at 550 Å with 250 μm slits was measured with a calibrated GaAs photodiode through a 1.5-mm diameter aperture in an aluminum mask on the photodiode. The new instrument has a microcomputer controlled mechanism which optimizes focussing requirements for a scanning monochromator with the requirement of fixed slits and fixed exit beam.
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| 4. |
- Andersen, J. N., et al.
(författare)
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Surface core-level shifts as a probe of the local overlayer structure : CO on Pd(100)
- 1991
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Ingår i: Physical Review Letters. - 0031-9007. ; 67:20, s. 2822-2825
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Tidskriftsartikel (refereegranskat)abstract
- The bonding energies of the Pd 3d and the C 1s core levels have been studied for the p(2 S 2 × 2) R45°, p(3 s2 × S2) R45°, and p(4 S 2 × S 2) R45°structures of CO on Pd(100). Adsorption of CO shifts the Pd 3d surface emission to higher binding energies with the magnitude of the shift depending almost linearly on the number of Pd to CO bonds; the measured shift per bond is close to 0.5 eV. A direct relation is established between the detailed geometry of the CO overlayer and the changes in the Pd 3d spectra.
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