| 1. |
- Kanai, M, et al.
(författare)
-
- 2023
-
swepub:Mat__t
|
|
| 2. |
- Glasbey, JC, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Munk, P., et al.
(författare)
-
Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
- 2022
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
-
Tidskriftsartikel (refereegranskat)abstract
- Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
|
|
| 7. |
- Soda, T., et al.
(författare)
-
International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic)
- 2020
-
Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 270:7, s. 921-932
-
Tidskriftsartikel (refereegranskat)abstract
- Recent genome-wide association studies have demonstrated that the genetic burden associated with depression correlates with depression severity. Therefore, conducting genetic studies of patients at the most severe end of the depressive disorder spectrum, those with treatment-resistant depression and who are prescribed electroconvulsive therapy (ECT), could lead to a better understanding of the genetic underpinnings of depression. Despite ECT being one of the most effective forms of treatment for severe depressive disorders, it is usually placed at the end of treatment algorithms of current guidelines. This is perhaps because ECT has controlled risk and logistical demands including use of general anaesthesia and muscle relaxants and side-effects such as short-term memory impairment. Better understanding of the genetics and biology of ECT response and of cognitive side-effects could lead to more personalized treatment decisions. To enhance the understanding of the genomics of severe depression and ECT response, researchers and ECT providers from around the world and from various depression or ECT networks, but not limited to, such as the Psychiatric Genomics Consortium, the Clinical Alliance and Research in ECT, and the National Network of Depression Centers have formed the Genetics of ECT International Consortium (Gen-ECT-ic). Gen-ECT-ic will organize the largest clinical and genetic collection to date to study the genomics of severe depressive disorders and response to ECT, aiming for 30,000 patients worldwide using a GWAS approach. At this stage it will be the largest genomic study on treatment response in depression. Retrospective data abstraction and prospective data collection will be facilitated by a uniform data collection approach that is flexible and will incorporate data from many clinical practices. Gen-ECT-ic invites all ECT providers and researchers to join its efforts.
|
|
| 8. |
|
|
| 9. |
- Srinivasaragavan, G. P., et al.
(författare)
-
PGIR 20eid (SN 2020qmp) : A Type IIP Supernova at 15.6 Mpc discovered by the Palomar Gattini-IR survey
- 2022
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 660
-
Tidskriftsartikel (refereegranskat)abstract
- Aims. We present a detailed analysis of SN 2020qmp, a nearby Type IIP core-collapse supernova (CCSN) that was discovered by the Palomar Gattini-IR survey in the galaxy UGC07125 (distance of approximate to 15.6 +/- 4 Mpc). We illustrate how the multiwavelength study of this event helps our general understanding of stellar progenitors and circumstellar medium (CSM) interactions in CCSNe. We highlight the importance of near-infrared (NIR) surveys for detections of supernovae in dusty environments.Methods. We analyze data from observations in various bands: radio, NIR, optical, and X-rays. We use optical and NIR data for a spectroscopic and spectro-polarimetric study of the supernova and to model its light curve (LC). We obtain an estimate of the zero-age main-sequence (ZAMS) progenitor mass from the luminosity of the [OI] doublet lines (lambda lambda 6300, 6364) normalized to the decay power of Co-56. We also independently estimate the explosion energy and ZAMS progenitor mass through hydrodynamical LC modeling. From radio and X-ray observations, we derive the mass-loss rate and microphysical parameters of the progenitor star, and we investigate possible deviations from energy equipartition of magnetic fields and electrons in a standard CSM interaction model. Finally, we simulate a sample of CCSNe with plausible distributions of brightness and extinction, within 40 Mpc, and test what fraction of the sample is detectable at peak light by NIR surveys versus optical surveys.Results. SN 2020qmp displays characteristic hydrogen lines in its optical spectra as well as a plateau in its optical LC, hallmarks of a Type IIP supernova. We do not detect linear polarization during the plateau phase, with a 3 sigma upper limit of 0.78%. Through hydrodynamical LC modeling and an analysis of its nebular spectra, we estimate a ZAMS progenitor mass of around 11.0 M-circle dot and an explosion energy of around 0.8x10(51) erg. We find that the spectral energy distribution cannot be explained by a simple CSM interaction model, assuming a constant shock velocity and a steady mass-loss rate. In particular, the excess X-ray luminosity compared with the synchrotron radio luminosity suggests deviations from equipartition. Finally, we demonstrate the advantages of NIR surveys over optical surveys for the detection of dust-obscured CCSNe in the local Universe. Specifically, our simulations show that the WideField Infrared Transient Explorer will detect up to 14 more CCSNe (out of the 75 expected in its footprint) within 40 Mpc over five years than would an optical survey equivalent to the Zwicky Transient Facility.Conclusions. We have determined or constrained the main properties of SN 2020qmp and its progenitor, highlighting the value of multiwavelength follow-up observations of nearby CCSNe. We have shown that forthcoming NIR surveys will enable us to improve constraints on the local CCSN rate by detecting obscured supernovae that would be missed by optical searches.
|
|
| 10. |
- Cruz, Raquel, et al.
(författare)
-
Novel genes and sex differences in COVID-19 severity
- 2022
-
Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 31:22, s. 3789-3806
-
Tidskriftsartikel (refereegranskat)abstract
- Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
|
|
