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Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
- Strakova, A. (author)
-
- Nicholls, Thomas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
- Baez-Ortega, A. (author)
- show more...
- Ni Leathlobhair, M. (author)
- Sampson, A. T. (author)
- Hughes, K. (author)
- Bolton, I. A. G. (author)
- Gori, K. (author)
- Wang, J. H. (author)
- Airikkala-Otter, I. (author)
- Allen, J. L. (author)
- Allum, K. M. (author)
- Arnold, C. L. (author)
- Bansse-Issa, L. (author)
- Bhutia, T. N. (author)
- Bisson, J. L. (author)
- Blank, K. (author)
- Briceno, C. (author)
- Domracheva, A. C. (author)
- Corrigan, A. M. (author)
- Cran, H. R. (author)
- Crawford, J. T. (author)
- Cutter, S. M. (author)
- Davis, E. (author)
- de Castro, K. F. (author)
- De Nardi, A. B. (author)
- de Vos, A. P. (author)
- Keena, L. D. (author)
- Donelan, E. M. (author)
- Huerta, A. R. E. (author)
- Faramade, I. A. (author)
- Fazil, M. (author)
- Fotopoulou, E. (author)
- Fruean, S. N. (author)
- Gallardo-Arrieta, F. (author)
- Glebova, O. (author)
- Gouletsou, P. G. (author)
- Hafelin Manrique, R. F. (author)
- Henriques, Jjgp (author)
- Horta, R. S. (author)
- Ignatenko, N. (author)
- Kane, Y. (author)
- King, C. (author)
- Koenig, D. (author)
- Krupa, A. (author)
- Kruzeniski, S. J. (author)
- Lanza-Perea, M. (author)
- Lazyan, M. (author)
- Quintana, A. M. L. (author)
- Losfelt, T. (author)
- Marino, G. (author)
- Martinez Castaneda, S. (author)
- Martinez-Lopez, M. F. (author)
- Masuruli, B. M. (author)
- Meyer, M. (author)
- Migneco, E. J. (author)
- Nakanwagi, B. (author)
- Neal, K. B. (author)
- Neunzig, W. (author)
- Nixon, S. J. (author)
- Ortega-Pacheco, A. (author)
- Pedraza-Ordonez, F. (author)
- Peleteiro, M. C. (author)
- Polak, K. (author)
- Pye, R. J. (author)
- Ramirez-Ante, J. C. (author)
- Reece, J. F. (author)
- Gutierrez, J. R. (author)
- Sadia, H. (author)
- Schmeling, S. K. (author)
- Shamanova, O. (author)
- Sherlock, A. G. (author)
- Steenland-Smit, A. E. (author)
- Svitich, A. (author)
- Tapia Martinez, L. J. (author)
- Ngoka, I. T. (author)
- Torres, C. G. (author)
- Tudor, E. M. (author)
- van der Wel, M. G. (author)
- Vitalaru, B. A. (author)
- Vural, S. A. (author)
- Walkinton, O. (author)
- Wehrle-Martinez, A. S. (author)
- Widdowson, S. A. E. (author)
- Zvarich, I. (author)
- Chinnery, P. F. (author)
- Falkenberg, M. (author)
- Gustafsson, C. M. (author)
- Murchison, E. P. (author)
- show less...
- (creator_code:org_t)
- 2020-06-16
- 2020
- English.
- In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby 'selfish' positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- phylogenetic analysis
- genome
- transcription
- sequence
- dog
- variants
- dynamics
- health
- cell
- tool
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
- Strakova, A.
- Nicholls, Thomas ...
- Baez-Ortega, A.
- Ni Leathlobhair, ...
- Sampson, A. T.
- Hughes, K.
- show more...
- Bolton, I. A. G.
- Gori, K.
- Wang, J. H.
- Airikkala-Otter, ...
- Allen, J. L.
- Allum, K. M.
- Arnold, C. L.
- Bansse-Issa, L.
- Bhutia, T. N.
- Bisson, J. L.
- Blank, K.
- Briceno, C.
- Domracheva, A. C ...
- Corrigan, A. M.
- Cran, H. R.
- Crawford, J. T.
- Cutter, S. M.
- Davis, E.
- de Castro, K. F.
- De Nardi, A. B.
- de Vos, A. P.
- Keena, L. D.
- Donelan, E. M.
- Huerta, A. R. E.
- Faramade, I. A.
- Fazil, M.
- Fotopoulou, E.
- Fruean, S. N.
- Gallardo-Arrieta ...
- Glebova, O.
- Gouletsou, P. G.
- Hafelin Manrique ...
- Henriques, Jjgp
- Horta, R. S.
- Ignatenko, N.
- Kane, Y.
- King, C.
- Koenig, D.
- Krupa, A.
- Kruzeniski, S. J ...
- Lanza-Perea, M.
- Lazyan, M.
- Quintana, A. M. ...
- Losfelt, T.
- Marino, G.
- Martinez Castane ...
- Martinez-Lopez, ...
- Masuruli, B. M.
- Meyer, M.
- Migneco, E. J.
- Nakanwagi, B.
- Neal, K. B.
- Neunzig, W.
- Nixon, S. J.
- Ortega-Pacheco, ...
- Pedraza-Ordonez, ...
- Peleteiro, M. C.
- Polak, K.
- Pye, R. J.
- Ramirez-Ante, J. ...
- Reece, J. F.
- Gutierrez, J. R.
- Sadia, H.
- Schmeling, S. K.
- Shamanova, O.
- Sherlock, A. G.
- Steenland-Smit, ...
- Svitich, A.
- Tapia Martinez, ...
- Ngoka, I. T.
- Torres, C. G.
- Tudor, E. M.
- van der Wel, M. ...
- Vitalaru, B. A.
- Vural, S. A.
- Walkinton, O.
- Wehrle-Martinez, ...
- Widdowson, S. A. ...
- Zvarich, I.
- Chinnery, P. F.
- Falkenberg, M.
- Gustafsson, C. M ...
- Murchison, E. P.
- show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- Articles in the publication
- Nature Communica ...
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- University of Gothenburg
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