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| 2. |
- Achterberg, A., et al.
(författare)
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The search for muon neutrinos from northern hemisphere gamma-ray bursts with AMANDA
- 2008
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 674:1, s. 357-370
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Tidskriftsartikel (refereegranskat)abstract
- We present the results of the analysis of neutrino observations by the Antarctic Muon and Neutrino Detector Array (AMANDA) correlated with photon observations of more than 400 gamma-ray bursts (GRBs) in the northern hemisphere from 1997 to 2003. During this time period, AMANDA's effective collection area for muon neutrinos was larger than that of any other existing detector. After the application of various selection criteria to our data, we expect similar to 1 neutrino event and <2 background events. Based on our observations of zero events during and immediately prior to the GRBs in the data set, we set the most stringent upper limit on muon neutrino emission correlated with GRBs. Assuming a Waxman-Bahcall spectrum and incorporating all systematic uncertainties, our flux upper limit has a normalization at 1 PeV of E-2 Phi(nu) <= 6.3 x 10(-9) GeV cm(-2) s(-1) sr(-1), with 90% of the events expected within the energy range of similar to 10 TeV to similar to 3 PeV. The impact of this limit on several theoretical models of GRBs is discussed, as well as the future potential for detection of GRBs by next-generation neutrino telescopes. Finally, we briefly describe several modifications to this analysis in order to apply it to other types of transient point sources.
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| 3. |
- Elsik, Christine G., et al.
(författare)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 4. |
- Chapin, III F.S., et al.
(författare)
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Resilience-based stewardship : Strategies for navigating sustainable pathways in a changing world.
- 2009
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Ingår i: Principles of ecosystem stewardship. - New York : Springer Verlag. - 9780387730332 ; , s. 319-337
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Bokkapitel (populärvet., debatt m.m.)abstract
- Accelerated global changes in climate, environment, and social–ecological systems demand a transformation in human perceptions of our place in nature and patterns of resource use. The biology and culture of Homo sapiens evolved for about 95% of our species’ history in hunting-and-gathering societies before the emergence of settled agriculture. We have lived in complex societies for about 3%, and in industrial societies using fossil fuels for about 0.1% of our history. The pace of cultural evolution, including governance arrangements and resource-use patterns, appears insufficient to adjust to the rate and magnitude of technological innovations, human population increases, and environmental impacts that have occurred. Many of these changes are accelerating, causing unsustainable exploitation of ecosystems, including many boreal and tropical forests, drylands, and marine fisheries. The net effect has been serious degradation of the planet’s life-support system on which societal development ultimately depends (see Chapters 2 and 14.
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| 5. |
- Caffau, E., et al.
(författare)
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The photospheric solar oxygen project - I. Abundance analysis of atomic lines and influence of atmospheric models
- 2008
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 488:3, s. 1031-1046
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Tidskriftsartikel (refereegranskat)abstract
- Context. The solar oxygen abundance has undergone a major downward revision in the past decade, the most noticeable one being the update including 3D hydrodynamical simulations to model the solar photosphere. Up to now, such an analysis has only been carried out by one group using one radiation-hydrodynamics code. Aims. We investigate the photospheric oxygen abundance considering lines from atomic transitions. We also consider the relationship between the solar model used and the resulting solar oxygen abundance, to understand whether the downward abundance revision is specifically related to 3D hydrodynamical effects. Methods. We performed a new determination of the solar photospheric oxygen abundance by analysing different high-resolution high signal-to-noise ratio atlases of the solar flux and disc-centre intensity, making use of the latest generation of CO5BOLD 3D solar model atmospheres. Results. We find 8.73 <= log (N-O/N-H) + 12 <= 8.79. The lower and upper values represent extreme assumptions on the role of collisional excitation and ionisation by neutral hydrogen for the NLTE level populations of neutral oxygen. The error of our analysis is +/- (0.04 +/- 0.03) dex, the last being related to NLTE corrections, the first error to any other effect. The 3D "granulation effects" do not play a decisive role in lowering the oxygen abundance. Conclusions. Our recommended value is log (N-O/N-H) = 8.76 +/- 0.07, considering our present ignorance of the role of collisions with hydrogen atoms on the NLTE level populations of oxygen. The reasons for lower O abundances in the past are identified as (1) the lower equivalent widths adopted and (2) the choice of neglecting collisions with hydrogen atoms in the statistical equilibrium calculations for oxygen.
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| 6. |
- Lockheart, M. S., et al.
(författare)
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Dietary patterns, food groups and myocardial infarction: a case-control study
- 2007
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Ingår i: Br J Nutr. - 0007-1145. ; 98:2, s. 380-7
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Tidskriftsartikel (refereegranskat)abstract
- Certain dietary patterns may be related to the risk of CVD. We hypothesised that a plant-centred dietary pattern would be associated with a reduced risk of first myocardial infarction (MI). A case-control study of Norwegian men and postmenopausal women (age 45-75 years) was performed. A FFQ was administered, generally within 3 d after incident MI (n 106 cases). Controls (n 105) were frequency matched on sex, age and geographic location. On the FFQ, 190 items were categorised into thirty-five food groups and an a priori healthy diet pattern score was created. We estimated OR using logistic regression with adjustment for energy intake, family history of heart disease, marital status, current smoking, education and age. Among food groups, the risk of MI was significantly higher per SD of butter and margarine (OR 1.66 (95 % CI 1.12, 2.46)), and lower per SD of tomatoes (OR 0.53 (95 % CI 0.35, 0.79)), high-fat fish (OR 0.57 (95 % CI 0.38, 0.86)), wine (OR 0.58 (95 % CI 0.41, 0.83)), salad (OR 0.59 (95 % CI 0.40, 0.87)), whole grain breakfast cereals (OR 0.64 (95 % CI 0.45, 0.90)), cruciferous vegetables (OR 0.66 (95 % CI 0.47, 0.93)) and non-hydrogenated vegetable oil (OR 0.68 (95 % CI 0.49, 0.95)). An abundance of cases were found to have a low a priori healthy diet pattern score. A dietary pattern emphasising nutrient-rich plant foods and high-fat fish and low in trans fatty acids was associated with decreased risk of MI among Norwegians.
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| 7. |
- Steffen, L M, et al.
(författare)
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Serum phospholipid and cholesteryl ester fatty acids and estimated desaturase activities are related to overweight and cardiovascular risk factors in adolescents
- 2008
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Ingår i: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 32:8, s. 1297-1304
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Tidskriftsartikel (refereegranskat)abstract
- Aim/hypothesis: The objective of this study was to describe the relation of serum fatty acids and desaturase activity (DA) to overweight, insulin sensitivity and cardiovascular disease (CVD) risk factors in adolescents. Methods: The relations of % serum phospholipid (PL) and cholesteryl ester (CE) fatty acids and estimated DA with CVD risk factors were examined in 264 adolescents (average age 15 years). Fatty acids were determined by gas liquid chromotography. Surrogate measures of DA were expressed as ratios of serum fatty acids: Delta 9 DA 16: 0/16: 1, Delta 6 DA 20: 3, n6/18: 2, n6 (PL) or 18: 3, n6/18: 2, n6 (CE), and Delta 5 DA 20: 4, n6/20: 3, n6. Spearman partial correlations of fatty acids (%) and DA ratios with CVD risk factors were reported, adjusting for age, sex, race, Tanner stage, energy intake and physical activity. Results: Overweight adolescents compared to normal weight had more adverse levels of CVD risk factors, composition of PL and CE fatty acids in serum, and D6 DA and D5 DA ratios. Linoleic acid was inversely related to body mass index (BMI), waist circumference and triglycerides (P < ;= 0.01). Dihomo-gamma-linolenic acid was positively related to BMI, waist, insulin, and triglycerides, and inversely related to high-density lipoprotein-cholesterol levels (P < ;= 0.01). D6 DA was adversely associated with most of the risk factors (P < ;= 0.01), whereas triglycerides and fasting insulin were beneficially related to D5 DA (P < ;= 0.01). Conclusion: These findings support those observed in adults, that factors, such as type of dietary fat, physical activity, and obesity, may influence fatty acid metabolism and are important in the development of adverse CVD risk factors as early as adolescence.
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| 8. |
- Almqvist, Ylva, et al.
(författare)
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In vitro and in vivo characterization of 177Lu‑huA33 : A radioimmunoconjugate against colorectal cancer
- 2006
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Ingår i: Nuclear Medicine and Biology. - : Elsevier BV. - 0969-8051 .- 1872-9614. ; 33:8, s. 991-998
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: The humanized monoclonal antibody A33 (huA33) is a potential targeting agent against colorectal carcinoma since the A33 antigen is highly and homogenously expressed in >95% of all colorectal cancers, both primary tumors and metastases. The aim of this study was to determine the biodistribution and tumor-targeting ability of (177)Lu-labeled huA33. METHODS: huA33 was labeled with the beta-emitting therapeutic nuclide (177)Lu using the chelator CHX-A"-DTPA, and the properties of the (177)Lu-CHX-A"-huA33 ((177)Lu-huA33) conjugate was determined both in vitro and in vivo in a biodistribution study in nude mice xenografted with colorectal SW1222 tumor cells. RESULTS: The (177)Lu-huA33 conjugate bound specifically to colorectal cancer cells in vitro (with a K(D) value of 2.3+/-0.3 nM, determined by a saturation assay) and in vivo. The tumor uptake of (177)Lu-huA33 was very high, peaking at 134+/-21%ID/g 72 h postinjection (pi). Normal tissue uptake was low; radioactivity concentration in blood (which had the second highest radioactivity concentration) was lower than in tumor at all time points studied (8 h to 10 days). The tumor-to-blood ratio increased with time, reaching 70+/-30, 10 days pi. Throughout the study, the uptake of (177)Lu in bone (known to accumulate free (177)Lu) was low, and the fraction of protein-bound (177)Lu in plasma samples was high (95% to 99%). This indicates high stability of the (177)Lu-huA33 conjugate in vivo. CONCLUSION: The (177)Lu-huA33 conjugate shows a very favorable biodistribution, with an impressively high tumor uptake and high tumor-to-organ ratios, indicating that the conjugate may be suitable for radioimmunotherapy of colorectal cancer.
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| 9. |
- Dengler, Jürgen, et al.
(författare)
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Working group on dry grasslands in the Nordic and Baltic region – Outline of the project and first results for the class Festuco-Brometea
- 2006
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Ingår i: Annali di Botanica N.S.. - 0365-0812. ; 6, s. 73-100
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Tidskriftsartikel (refereegranskat)abstract
- The vegetation databank established by our working group covers the classes Festuco-Brometea, Koelerio-Corynephoretea, and Trifolio-Geranietea sanguinei in the Nordic and Baltic region, i.e. NE Germany, Denmark, Norway, Sweden, Finland, N Poland, Lithuania, Latvia, Estonia, and NW Russia. We aim to use these data to develop a consistent supra-national phytosociological classification of these xerothermic vegetation types in the study area and to analyse their biodiversity patterns. Up to now, we located some 12,500 relevés meeting our criteria, and more than 3,500 of them have already been included in the databank. We give an overview of the properties of these relevés as regards coverage of syntaxa and countries, source types, plot sizes, and cryptogam treatment. We also present first analyses for the basiphilous semi-dry grasslands (Brachypodietalia pinnati) within the Festuco-Brometea. For this group of communities, many different and incompatible classification schemes have been proposed. We give an overview of the alliance and association names that have been in use for them in the study area, accompanied by a nomenclatural assessment. The relevés presently included in the databank have been tentatively assigned to those vegetation classes whose diagnostic taxa were prevailing. Accordingly, more than 2,000 relevés have been placed in the Festuco-Brometea. These show considerable floristic differences compared to stands of the southern temperate Brachypodietalia pinnati alliances Bromion erecti, Cirsio-Brachypodion pinnati, and Agrostion vinealis. The presence degrees of Avenula pratensis and Homalothecium lutescens, for instance, are significantly increased in the study area, and those of Festuca rupicola and Euphorbia cyparissias decreased. An analysis of the species-area relationship yielded a power function with z = 0.09 which is considerably lower than increments determined by nested-plot analyses of this commu-nity type, indicating the probable incompleteness of the species lists for many of the larger plots. Finally, we give an outlook on the future objectives of the working group.
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