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Alterations in regu...
Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice
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Choi, Young Hun (författare)
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Park, Sunhee (författare)
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Hockman, Steven (författare)
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Zmuda-Trzebiatowska, Emilia (författare)
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- Svennelid, Fredrik (författare)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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Haluzik, Martin (författare)
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Gavrilova, Oksana (författare)
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Ahmad, Faiyaz (författare)
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Pepin, Laurent (författare)
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Napolitano, Maria (författare)
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Taira, Masato (författare)
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- Sundler, Frank (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Stenson, Lena (författare)
- Lund University,Lunds universitet,Signaltransduktionsforskning,Forskargrupper vid Lunds universitet,Insulin Signal Transduction,Lund University Research Groups
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- Degerman, Eva (författare)
- Lund University,Lunds universitet,Signaltransduktionsforskning,Forskargrupper vid Lunds universitet,Insulin Signal Transduction,Lund University Research Groups
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Manganiello, Vincent C. (författare)
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: Journal of Clinical Investigation. - 0021-9738. ; 116:12, s. 3240-3251
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cyclic nucleotide phosphodiesterase 3B (PDE3B) has been suggested to be critical for mediating insulin/IGF-1 inhibition of cAMP signaling in adipocytes, liver, and pancreatic beta cells. In Pde3b-KO adipocytes we found decreased adipocyte size, unchanged insulin-stimulated phosphorylation of protein kinase B and activation of glucose uptake, enhanced catecholamine-stimulated lipolysis and insulin-stimulated hpogenesis, and blocked insulin inhibition of catecholamine-stimulated lipolysis. Glucose, alone or in combination with glucagon-like peptide-1, increased insulin secretion more in isolated pancreatic KO islets, although islet size and morphology and immunoreactive insulin and glucagon levels were unchanged. The beta(3)-adrenergic agonist CL 316,243 (CL) increased lipolysis and serum insulin more in KO mice, but blood glucose reduction was less in CL-treated KO mice. Insulin resistance was observed in KO mice, with liver an important site of alterations in insulin-sensitive glucose production. In KO mice, liver triglyceride and cAMP contents were increased, and the liver content and phosphorylation states of several insulin signaling, gluconeogenic, and inflammation- and stress-related components were altered. Thus, PDE3B may be important in regulating certain cAMP signaling pathways, including lipolysis, insulin-induced antilipolysis, and cAMP-mediated insulin secretion. Altered expression and/or regulation of PDE3B may contribute to metabolic dysregulation, including systemic insulin resistance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
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Till lärosätets databas
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Choi, Young Hun
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Park, Sunhee
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Hockman, Steven
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Zmuda-Trzebiatow ...
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Svennelid, Fredr ...
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Haluzik, Martin
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visa fler...
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Gavrilova, Oksan ...
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Ahmad, Faiyaz
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Pepin, Laurent
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Napolitano, Mari ...
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Taira, Masato
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Sundler, Frank
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Stenson, Lena
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Degerman, Eva
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Manganiello, Vin ...
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visa färre...
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Lunds universitet