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- Willer, Cristen J., et al.
(author)
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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
- 2009
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:1, s. 25-34
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Journal article (peer-reviewed)abstract
- Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
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- Graslund, S, et al.
(author)
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Protein production and purification
- 2008
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In: Nature methods. - : Springer Science and Business Media LLC. - 1548-7105 .- 1548-7091. ; 5:2, s. 135-146
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Journal article (peer-reviewed)
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- Genkinger, Jeanine M., et al.
(author)
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Alcohol Intake and Pancreatic Cancer Risk : A Pooled Analysis of Fourteen Cohort Studies
- 2009
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In: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 18:3, s. 765-776
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Research review (peer-reviewed)abstract
- Background: Few risk factors have been implicated in pancreatic cancer etiology. Alcohol has been theorized to promote carcinogenesis. However, epidemiologic studies have reported inconsistent results relating alcohol intake to pancreatic cancer risk. Methods: We conducted a pooled analysis of the primary data from 14 prospective cohort studies. The study sample consisted of 862,664 individuals among whom 2,187 incident pancreatic cancer cases were identified. Study-specific relative risks and 95% confidence intervals were calculated using Cox proportional hazards models and then pooled using a random effects model. Results: A slight positive association with pancreatic cancer risk was observed for alcohol intake (pooled multivariate relative risk, 1.22; 95% confidence interval, 1.03-1.45 comparing >= 30 to 0 grams/day of alcohol; P value, test for between-studies heterogeneity = 0.80). For this comparison, the positive association was only statistically significant among women although the difference in the results by gender was not statistically significant (P value, test for interaction = 0.19). Slightly stronger results for alcohol intake were observed when we limited the analysis to cases with adenocarcinomas of the pancreas. No statistically significant associations were observed for alcohol from wine, beer, and spirits comparing intakes of >= 5 to 0 grams/day. A stronger positive association between alcohol consumption and pancreatic cancer risk was observed among normal weight individuals compared with overweight and obese individuals (P value, test for interaction = 0.01). Discussion: Our findings are consistent with a modest increase in risk of pancreatic cancer with consumption of 30 or more grams of alcohol per day. (Cancer Epidemiol Biomarkers Prev 2009;18(3):765-76)
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- Pereira, M A, et al.
(author)
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Dietary fiber, folate, and vitamin E with coronary risk : A pooled analysis of cohort studies
- 2006
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In: Circulation. - Univ Minnesota, Minneapolis, MN USA. Harvard Univ, Boston, MA 02115 USA. Karolinska Inst, Stockholm, Sweden. Loma Linda Univ, Loma Linda, CA 92350 USA. Neufeld Cardiac Res Inst, Tel Hashomer, Israel. Copenhagen Univ Hosp, Copenhagen, Denmark. Umea Univ, Umea, Sweden. Natl Publ Hlth Inst, Helsinki, Finland. Inst Publ Hlth, Helsinki, Finland. Inst Publ Hlth, Helsinki, Finland. Univ N Carolina, Chapel Hill, NC USA. : LIPPINCOTT WILLIAMS & WILKINS. - 0009-7322 .- 1524-4539. ; 113:8, s. E374-E375
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Journal article (other academic/artistic)
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- Cubillas, Pablo, et al.
(author)
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Spiral Growth on Nanoporous Silicoaluminophosphate STA-7 as Observed by Atomic Force Microscopy
- 2009
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In: Crystal Growth & Design. - : American Chemical Society (ACS). - 1528-7483 .- 1528-7505. ; 9:9, s. 4041-4050
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Journal article (peer-reviewed)abstract
- Atomic force microscopy was used to study the surface of STA-7 crystals. STA-7 is a silicoaluminophosphate, nanoporous solid formed by interlinked double six ring units (D6R). Observations showed the formation of three distinct types of spirals at tow supersaturation conditions. The {001} face shows spirals with isotropic shapes and a Burgers vector of 0.9 nm, which corresponds to one D6R or one unit cell along the < 001 > direction. The {100} face contains two distinct types of spirals. The first has a Burgers vector of 0.9 rim, or half a unit cell along < 100 >. This dislocation produces a change in the ""stacking"" sequence of the D6Rs generating all overgrowth with the AEI structure. The second type is an interlaced spiral and is generated by a dislocation with a Burgers vector of 1.8 nm or one unit cell, leading to the formation of two substeps each with a different growth anisotropy. This anisotropy is directed by the shape of the substep and the energetics of template attachment. The preponderance of a surface coating of a secondary phase will have significant consequences on applications reliant on intracrystalline diffusion, such as catalysis, where, owing to diffusion limitations, the outermost structure dominates the functional properties.
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