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- Abdalla, H., et al.
(författare)
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Sensitivity of the Cherenkov Telescope Array for probing cosmology and fundamental physics with gamma-ray propagation
- 2021
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Ingår i: Journal of Cosmology and Astroparticle Physics. - : Institute of Physics Publishing (IOPP). - 1475-7516. ; :2
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Tidskriftsartikel (refereegranskat)abstract
- The Cherenkov Telescope Array (CTA), the new-generation ground-based observatory for gamma-ray astronomy, provides unique capabilities to address significant open questions in astrophysics, cosmology, and fundamental physics. We study some of the salient areas of gamma-ray cosmology that can be explored as part of the Key Science Projects of CTA, through simulated observations of active galactic nuclei (AGN) and of their relativistic jets. Observations of AGN with CTA will enable a measurement of gamma-ray absorption on the extragalactic background light with a statistical uncertainty below 15% up to a redshift z = 2 and to constrain or detect gamma-ray halos up to intergalactic-magnetic-field strengths of at least 0.3 pG. Extragalactic observations with CTA also show promising potential to probe physics beyond the Standard Model. The best limits on Lorentz invariance violation from gamma-ray astronomy will be improved by a factor of at least two to three. CTA will also probe the parameter space in which axion-like particles could constitute a significant fraction, if not all, of dark matter. We conclude on the synergies between CTA and other upcoming facilities that will foster the growth of gamma-ray cosmology.
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| 2. |
- Khatri, B., et al.
(författare)
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Genome-wide association study identifies Sjogren's risk loci with functional implications in immune and glandular cells
- 2022
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Sjogren's disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjogren's cases of European ancestry: CD247, NAB1, PTTG1-MIR146A, PRDM1-ATG5, TNFAIP3, XKR6, MAPT-CRHR1, RPTOR-CHMP6-BAIAP6, TYK2, SYNGR1. Polygenic risk scores yield predictability (AUROC = 0.71) and relative risk of 12.08. Interrogation of bioinformatics databases refine the associations, define local regulatory networks of GWS SNPs from the 95% credible set, and expand the implicated gene list to >40. Many GWS SNPs are eQTLs for genes within topologically associated domains in immune cells and/or eQTLs in the main target tissue, salivary glands. The genetic architecture underlying Sjogren's syndrome is not fully understood. Here, the authors perform a genome-wide association study to identify 10 new genetic risk regions, implicating genes involved in immune and salivary gland function.
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| 7. |
- Nowak, K., et al.
(författare)
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Question of local exploitation of copper ore deposits in the Urnfield time in Poland
- 2023
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Ingår i: Frontiers in Earth Sciences. - 1863-4621 .- 1863-463X. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Despite rich deposits of copper in SW Poland, their exploitation in prehistory has not been confirmed, and in the literature it is usually argued that raw materials processed in the Bronze Age were imported. This is despite the same area providing abundant evidence of prehistoric metallurgy including casting moulds, tuyeres or crucibles. The concentration of prehistoric sites in parts of the Sudety Mountains (in particular a region called Pogorze Kaczawskie) rich in copper ores and far from arable land may also indicate prehistoric prospection activities in this area in the search for raw materials. In this paper, we discuss the issue of the provenance of the metal used in SW Poland, an area where metallurgy-related items dated to the Urnfield period (ca. 1300-500/450 BC) are most numerous. Our study utilises historical evidence of pre-modern mining, GIS analysis of prehistoric sites, and lead isotopic analyses conducted on bronze (n=35) and lead (n=1) artefacts found near the copper outcrops in Silesia, and compared with European lead isotope databases. The lead isotopic data for the Zechstein Limestone (Ca1) ores from a local mine and modern black copper from blast furnaces at Leszczyna and Chelmiec in SW Poland were also analysed as reference data (n=6). Our research demonstrates that metal objects in SW Poland were made of copper obtained from various parts of Europe confirming intense contacts of the Urnfield communities but the lead ornaments were sourced from material of local origin providing the first evidence for the provenance of Polish lead.
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| 8. |
- Nowak, K., et al.
(författare)
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The Late Bronze Age 'metallurgists' graves’ in south-western Poland. Tracing the provenance of the metal raw material using casting moulds
- 2022
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Ingår i: Journal of Archaeological Science: Reports. - : Elsevier BV. - 2352-409X. ; 42
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Tidskriftsartikel (refereegranskat)abstract
- A collection of objects associated with prehistoric metallurgy, including casting moulds, a casting core, and a fragment of a tuyere, were found in three metallurgists’ graves in the Late Bronze Age cemetery in Legnica, south-west Poland. The finds from these graves presented an opportunity for a scientific investigation of several aspects of Bronze Age metallurgy in this region by applying various analytical procedures to characterise the remains of metals inside the casting moulds. We also analysed metal used for the repair of one of the moulds, and the razor from one of the graves that could have been cast in a mould discovered in another grave. One of the aims of this research project was to establish a possible provenance of the metal used by the population buried in these so-called metallurgists' graves using the chemical and lead isotope analysis. The casting moulds had clear wear marks providing proof of their use. In two cases, the moulds had thick greenish-black layers possibly representing remains of a corroded metal. The chemical compositions of these layers and metal from two other artefacts was investigated using ED XRF and SEM EDS. These analyses showed the diversity of the metals used for castings. Lead isotope analyses using MC ICP MS provided information about the possible origin of lead in the remains from the moulds. The most likely source of this lead is from the ores in the Erzgebirge, in eastern Germany, a few hundred kilometres south west from the site of the graves. The provenance of lead from the razor and from the repair of the mould can be either from the Erzgebirge or Slovak Ore Mountains, or a mixture of these ores. © 2022
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