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BL1391 : an establi...
BL1391 : an established cell line from a human malignant peripheral nerve sheath tumor with unique genomic features
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- Tolomeo, Doron (författare)
- University of Bari Aldo Moro
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- Agostini, Antonio (författare)
- Bari University Hospital
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- Macchia, Gemma (författare)
- University of Bari Aldo Moro
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- L’Abbate, Alberto (författare)
- University of Bari Aldo Moro,CNR Istituto per le Tecnologie Applicate ai Beni Culturali (CNR-ITABC)
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- Severgnini, Marco (författare)
- CNR Institute for Biomedical Technologies (ITB-CNR)
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- Cifola, Ingrid (författare)
- CNR Institute for Biomedical Technologies (ITB-CNR)
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- Frassanito, Maria Antonia (författare)
- Bari University Hospital
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- Racanelli, Vito (författare)
- Bari University Hospital
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- Solimando, Antonio Giovanni (författare)
- Istituto Tumori 'Giovanni Paolo II',Bari University Hospital
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- Haglund, Felix (författare)
- Karolinska Institutet
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- Mertens, Fredrik (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetiska avvikelser i mjukdelstumörer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,The genetics of soft tissue tumors,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Storlazzi, Clelia Tiziana (författare)
- University of Bari Aldo Moro
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(creator_code:org_t)
- 2020-08-27
- 2021
- Engelska.
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Ingår i: Human Cell. - : Springer Science and Business Media LLC. - 0914-7470 .- 1749-0774. ; 34:1, s. 238-245
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive tumors, accounting for around 5% of all soft tissue sarcomas. A better understanding of the pathogenesis of these tumors and the development of effective treatments are needed. In this context, established tumor cell lines can be very informative, as they may be used for in-depth molecular analyses and improvement of treatment strategies. Here, we present the genomic and transcriptomic profiling analysis of a MPNST cell line (BL1391) that was spontaneously established in our laboratory from a primary tumor that had not been exposed to genotoxic treatment. This cell line shows peculiar genetic features, such as a large marker chromosome composed of high-copy number amplifications of regions from chromosomes 1 and 11 with an embedded neocentromere. Moreover, the transcriptome profiling revealed the presence of several fusion transcripts involving the CACHD1, TNMA4, MDM4, and YAP1 genes, all of which map to the amplified regions of the marker. BL1391 could be a useful tool to study genomic amplifications and neocentromere seeding in MPNSTs and to develop new therapeutic strategies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Amplification
- BL1391
- Fusion transcript
- MPNST
- Neocentromere
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tolomeo, Doron
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Agostini, Antoni ...
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Macchia, Gemma
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L’Abbate, Albert ...
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Severgnini, Marc ...
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Cifola, Ingrid
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visa fler...
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Frassanito, Mari ...
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Racanelli, Vito
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Solimando, Anton ...
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Haglund, Felix
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Mertens, Fredrik
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Storlazzi, Cleli ...
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Human Cell
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Lunds universitet
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Karolinska Institutet