| 1. |
- Brodd, Katarina Strand, et al.
(författare)
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Development of smooth pursuit eye movements in very preterm infants : 1. General aspects
- 2011
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 100:7, s. 983-991
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To investigate early oculo-motor development in a population-based cohort of very preterm infants.Methods: Early oculo-motor development was prospectively studied by measuring smooth pursuit eye movements at 2 and 4 months corrected age in a population of very preterm infants born in Uppsala County 2004–2007. Eighty-one preterm infants were studied, and 32 healthy term infants constituted the control group.Results: The study group consisted of infants with a mean gestational age of28 + 5 weeks. At 2 and 4 months corrected age, infants born very preterm showed lower gain (p < 0.001) and proportion of smooth pursuit eyemovements (p < 0.001) compared to the control group. The boys showed higher gain of smooth pursuit eye movements at both 2 and 4 months corrected age, compared to girls.Conclusions: Oculo-motor development measured by smooth pursuit eye movements is delayed in very preterm infants at 2 and 4 months corrected age. This might be a risk factor or early indicator of later perceptual and behavioural impairment.
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| 2. |
- Flöistrup, Erik, et al.
(författare)
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Synthesis of estradiol backbone mimics via the Stille reaction using copper(II) oxide as co-reagent
- 2011
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Ingår i: Tetrahedron Letters. - : Elsevier BV. - 0040-4039 .- 1359-8562. ; 52:2, s. 209-211
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Tidskriftsartikel (refereegranskat)abstract
- Sterically hindered biaryls and 2-phenylbenzo[b]thiophenes that can serve as templates for mimics of the estradiol backbone were prepared in modest to good yields by the Stille reaction using CuO as a co-reagent. Due to the neutral conditions applied in the Stille reaction, protection strategies were unnecessary for hydroxy containing coupling partners. Ligandless coupling conditions were also evaluated.
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| 3. |
- Lindbergh, Tobias, et al.
(författare)
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Improved model for myocardial diffuse reflectance spectra by including mitochondrial cytochrome aa3, methemoglobin, and inhomogenously distributed RBC
- 2011
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Ingår i: Journal of Biophotonics. - : John Wiley & Sons. - 1864-063X .- 1864-0648. ; 4:4, s. 268-276
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Tidskriftsartikel (refereegranskat)abstract
- Hemo- and myoglobin oxygen saturation and cytochrome aa3 oxidation was locally assessed using calibrated diffuse reflectance spectroscopy in fourteen patients undergoing coronary artery bypass grafting. Diffuse spectral reflectance data, recorded with a handheld fiberoptic probe with a single source-detector separation, was analyzed using an empirical light transport model relating the absorption and reduced scattering coefficients to the measured spectrum. The absorption coefficient has previously been modeled as a sum of hemoglobin and myoglobin, fat, and water. In this study, inclusion of cytochrome aa3 and the sum of methemoglobin and metmyoglobin improved the spectral fit, especially in the wavelength regions where their absorption is prominent. On average, the extended model increased the mean R2 from 0.96 to 0.99 and displayed 4% units higher saturation levels. After aorta cross-clamping, the sum of hemo- and myoglobin oxygen saturation increased while cytochrome aa3 oxidation decreased slightly. Opposite trends were observed during cardiac arrest. At reperfusion, the saturation increased compared to the levels found at cardiac arrest, and the cytochrome aa3 oxidation was restored. The estimated tissue chromophore fractions, saturation and oxidation, were in agreement with other studies.
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| 4. |
- Rönning, Helén, et al.
(författare)
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Description and initial evaluation of an educational and psychosocial support model for adults with congenitally malformed hearts
- 2011
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Ingår i: Patient Education and Counseling. - : Elsevier. - 0738-3991 .- 1873-5134. ; 83:2, s. 247-251
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Various programmes for adults with congenitally malformed hearts have been developed, but detailed descriptions of content, rationale and goals are often missing. The aim of this study was to describe and make an initial evaluation of a follow-up model for adults with congenitally malformed hearts, focusing on education and psychosocial support by a multidisciplinary team (EPS). METHODS: The model is described in steps and evaluated with regards to perceptions of knowledge, anxiety and satisfaction. RESULTS: The EPS model included a policlinic visit to the physician/nurse (medical consultation, computer-based and individual education face-to-face as well as psychosocial support) and a 1-month telephone follow-up. Fifty-five adults (mean age 34, 29 women) with the nine most common forms of congenitally malformed hearts participated in the EPS model as well as the 3-months follow-up. Knowledge about congenital heart malformation had increased in 40% of the participants at the 3-months follow-up. CONCLUSION: This study describes and evaluates a model that combines a multidisciplinary approach and computer-based education for follow-up of adults with congenitally malformed hearts. The EPS model was found to increase self-estimated knowledge, but further evaluations need to be conducted to prove patient-centred outcomes over time. PRACTICE IMPLICATIONS: The model is now ready to be implemented in adults with congenitally malformed hearts.
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| 5. |
- Rönning, Helén, et al.
(författare)
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Development and evaluation of a computer-based educational program for adults with congenitally malformed hearts
- 2013
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Ingår i: European Journal of Cardiovascular Nursing. - : Oxford University Press (OUP). - 1474-5151 .- 1873-1953. ; 12:1, s. 78-86
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Tidskriftsartikel (refereegranskat)abstract
- Background: There is a lack o educational material for adults with congenitally malformed hearts. Computer-based education has shown to have significant effects on knowledge and management of chronic diseases. Aim: The aim of this study was to develop and evaluate a computer-based educational program for adults with congenitally malformed hearts. Methods: The program was developed by a multidisciplinary team. Data were collected by questionnaires, observations, and structured interviews. Results: The final product was a computer-based educational program consisting of ten separate modules, one for each particular malformation. The program was experienced as stimulating and easy to use. The appearance and quantity of the text was graded as good and the content as relevant and very useful. Conclusion: This is the first computer-based program developed for adults with congenitally malformed hearts. The evaluation found the program to have great potential as an important tool for improving care. Further studies are needed to test the outcomes of the program on knowledge, perceived control over the heart condition, anxiety/depression. and health-related quality of life. Practice implications: The program may be used as a complement to verbal information and every adult with a congenitally malformed hearts can receive individualized information from a personal CD.
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| 6. |
- Rönning, Helén, et al.
(författare)
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Development and psychometric evaluation of the knowledge scale for adults with congenitally malformed hearts
- 2013
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Ingår i: Journal of Cardiovascular Nursing. - 0889-4655 .- 1550-5049. ; 28:3, s. 228-237
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Tidskriftsartikel (refereegranskat)abstract
- Background and Research Objective: Adults with congenitally malformed hearts have knowledge gaps regarding their heart condition, and their level of knowledge is not routinely assessed during follow-up. One reason for this is that there are few validated, user-friendly questionnaires to assess knowledge about congenital heart disease and its effects on daily life. Failure to identify low levels of knowledge could lead to less motivated and insecure individuals not actively involved in treatment and care of their heart condition. Therefore, the objective of this study was to develop and test a knowledge scale for adults with congenitally malformed hearts.Participants and Methods: The development and psychometric evaluation of the Knowledge Scale for Adults With Congenitally Malformed Hearts (KnoCoMH) followed 2 phases: (1) development and evaluation of the initial version, with face validity and content validity assessed by experts and adults with congenitally malformed hearts, and (2) evaluation and refinement of the KnoCoMH in adults with congenitally malformed hearts, including item difficulty level, internal consistency, and test-retest reliability.Results: The development and evaluation of a knowledge scale for adults with congenitally malformed hearts resulted in the KnoCoMH including 46 items in 4 domains: General Knowledge, with a Kuder-Richardson formula 20 (KR-20) value of 0.68; Medical Treatment, with a KR-20 value of 0.74; Endocarditis Prophylaxis, with a KR-20 value of 0.90; and Contraceptives and Pregnancy, with a KR-20 value of 0.65. Test-retest evaluation showed significant correlations between 0.50 and 0.67 (P < .01) in all 4 domains. There was good variation in item difficulty, with a mean value of 0.56 in General Knowledge, 0.62 in Medical Treatment, 0.33 in Endocarditis Prophylaxis, and 0.48 in Contraceptives and Pregnancy.Conclusions: The KnoCoMH has acceptable psychometric properties for most of the knowledge domains included. It can be used for evaluating knowledge among adults with congenitally malformed hearts and its associations with other outcomes. However, further studies are advisable to test construct validity, predictive validity, and responsiveness.
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| 7. |
- Rönning, Helén, et al.
(författare)
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Evaluation of a model focusing on computer-based and individualized care by face-to-face psycho-education for adults with congenitally malformed hearts: a randomized controlled trial
- 2014
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Ingår i: Experimental & Clinical Cardiology. ; 20:9, s. 5349-5369
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Evaluate the effects of a psycho-educational model for follow-up in adults with congenitally malformed hearts.Methods: The study had a randomized controlled design. Usual care was compared with computer-based and individualized care by face-to-face psycho-education by a multidisciplinary team. Knowledge and perceived control regarding the heart condition, symptoms of anxiety and depression was analysed at baseline, 3 and 12-months.Results: The 114 participants (control group n=58, intervention group n=56) had an average age of 34 years, SD 13.5. The intervention group had significantly higher general knowledge after 3 (effect size (ES) 0.63, p= <0.01), and 12-months (ES 0.53, p= 0.02). Knowledge regarding endocarditis was significantly increased at 3 (ES 1.43, p=<0.001), and 12-months (ES 0.58, p= 0.02) compared to baseline. There were no changes in knowledge regarding medical treatment, contraceptives and pregnancy, perceived control or anxiety and depression in any of the groups.Conclusion: The model for follow-up was effective to improve and maintain knowledge about self-management.Practice implication: Future evaluation of how the improved knowledge will affect health behaviours over-time is needed. Clinical Trials NCT01234753
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| 8. |
- Rönning, Helén, et al.
(författare)
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Evaluation of knowledge, perceived control, symptoms of anxiety and depression related to a model for follow-up in adults with congenitally malformed hearts: a randomised control trial
- 2011
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Objective: To evaluate the effects of a model including computer-based and individualised education and psychosocial support for adults with congenitally malformed hearts. Design: Prospective randomised controlled multicentre trial. Setting: Four hospital outpatient clinics in Sweden. Participants: Adults with congenitally malformed hearts. Interventions: Comparing usual care twith education and psychosocial support by a multidisciplinary team. Main Outcome Measures: Knowledge and perceived control regarding the heart condition, and symptoms of anxiety and depression at baseline, 3 and 12-months follow-up. Results: Out of 114 included participants, 58 were randomised to the control group, and 56 to the intervention group. The average age was 34 (SD 13.5) years. Results showed a significant between-group treatment effect in general knowledge after 3 months (effect size 0.63, p=<0.01), and 12-month (effect size 0.53, p= 0.02). Knowledge regarding endocarditis also increased significantly between-group after 3 months (effect size 0.87, p= <0.01), and over time between baseline and 3 months (effect size 1.43, p=<0.001), and between baseline and 12-months (effect size 0.58, p= 0.02). There were no changes in knowledge in domains regarding self-management of medical treatment and contraceptives and pregnancy in any of the groups. Further, the intervention did neither increase nor decrease the perceived control over the heart condition or symptoms of anxiety and depression. Conclusion: Education and psychosocial support by a multidisciplinary team was effective in improving and maintaining knowledge about self-management in adults with heart malformation. Future research is needed to determine the long-time effects on selfmanagement behaviours and perceived control.
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| 9. |
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| 10. |
- Rönning, Helén
(författare)
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Follow-up of adults with congenitally malformed hearts with focus on individualised and computer-based education and psychosocial support : A descriptive and interventional study
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background and aims: Many adults with congenitally malformed hearts are at risk for complications such as decreased function and capacity of the heart due to the heart defect and previously surgery. This advocates self-management behaviours related to medical treatments, physical activity, preventions of endocarditis, some restrictions regarding suitable employment and spare time activities, birth control and pregnancy, but also lifestyle concerns such as refraining from smoking and healthy eating. Sufficient knowledge and support are requirements for successful self-management. The overall aim of this thesis was to describe educational needs, develop a tool for assessing knowledge and to evaluate the effects of a follow-up model providing education and psychosocial support to adults with congenitally malformed hearts.Subjects and methods: Adults (≥18 years of age) with the ten most common heart defects namely ventricular septal defect, atrial septal defect, coarctation of the aortae, aortic valve stenosis (defined as uncomplicated heart defects) and tetralogy of Fallot, complete transposition of the great arteries, congenitally corrected transposition of the great arteries, Ebstein anomaly and Eisenmenger syndrome (defined as complicated heart defects) were included in the studies. To apprehend the educational needs (I), sixteen adults with heart malformations, ranging from 19-55 years of age, were interviewed and data were analysed qualitatively using phenomenographic method. As a tool to evaluate knowledge, an instrument named Knowledge scale for adults with Congenital Malformed Hearts (KnoCoMH) was developed and psychometrically evaluated (II) in 19 + 114 adults with the ten most common heart defects average age 34 ± 13.5. A model for follow-up was described and initially evaluated (III) by 55 adults with the most common heart defects and finally tested in a randomised controlled trial (IV) with a total of 114 adults with congenitally malformed hearts (56 participants in intervention group and 58 in control group with average age 34 ± 13.5). The intervention group recived a model for follow-up with individualise and computer-based eduction and psychosocial support by a multidisciplinary team.Results: Two-way communication when given information was found to be crucial in order to enhance knowledge (I). Knowledge was seen as a tool for managing important areas in life. The KnoCoMH (II) was found to be a valid and reliable scale and can now be used to estimate knowledge in adults with congenitally malformed hearts. The model for follow-up (III) was effective in improving and maintaining knowledge (IV) about self-management in adults with heart malformation.
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