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- Boxall, A. B. A., et al.
(författare)
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Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions?
- 2012
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Ingår i: Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 120:9, s. 1221-1229
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Over the past 10-15 years, a substantial amount of work has been done by the scientific, regulatory, and business communities to elucidate the effects and risks of pharmaceuticals and personal care products (PPCPs) in the environment. OBJECTIVE: This review was undertaken to identify key outstanding issues regarding the effects of PPCPs on human and ecological health in order to ensure that future resources will be focused on the most important areas. DATA SOURCES: To better understand and manage the risks of PPCPs in the environment, we used the "key question" approach to identify the principle issues that need to be addressed. Initially, questions were solicited from academic, government, and business communities around the world. A list of 101 questions was then discussed at an international expert workshop, and a top-20 list was developed. Following the workshop, workshop attendees ranked the 20 questions by importance. DATA SYNTHESIS: The top 20 priority questions fell into seven categories: a) prioritization of substances for assessment, b) pathways of exposure, c) bioavailability and uptake, a effects characterization, e) risk and relative risk, f) antibiotic resistance, and g) risk management. CONCLUSIONS: A large body of information is now available on PPCPs in the environment. This exercise prioritized the most critical questions to aid in development of future research programs on the topic.
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- Guergueltcheva, V., et al.
(författare)
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Congenital myasthenic syndrome with tubular aggregates caused by GFPT1 mutations
- 2012
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Ingår i: Journal of Neurology. - : Springer Science and Business Media LLC. - 0340-5354 .- 1432-1459. ; 259:5, s. 838-850
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Tidskriftsartikel (refereegranskat)abstract
- Congenital myasthenic syndrome (CMS) is a clinically and genetically heterogeneous group of inherited disorders of the neuromuscular junction. A difficult to diagnose subgroup of CMS is characterised by proximal muscle weakness and fatigue while ocular and facial involvement is only minimal. DOK7 mutations have been identified as causing the disorder in about half of the cases. More recently, using classical positional cloning, we have identified mutations in a previously unrecognised CMS gene, GFPT1, in a series of DOK7-negative cases. However, detailed description of clinical features of GFPT1 patients has not been reported yet. Here we describe the clinical picture of 24 limb-girdle CMS (LG-CMS) patients and pathological findings of 18 of them, all carrying GFPT1 mutations. Additional patients with CMS, but without tubular aggregates, and patients with non-fatigable weakness with tubular aggregates were also screened. In most patients with GFPT1 mutations, onset of the disease occurs in the first decade of life with characteristic limb-girdle weakness and fatigue. A common feature was beneficial and sustained response to acetylcholinesterase inhibitor treatment. Most of the patients who had a muscle biopsy showed tubular aggregates in myofibers. Analysis of endplate morphology in one of the patients revealed unspecific abnormalities. Our study delineates the phenotype of CMS associated with GFPT1 mutations and expands the understanding of neuromuscular junction disorders. As tubular aggregates in context of a neuromuscular transmission defect appear to be highly indicative, we suggest calling this condition congenital myasthenic syndrome with tubular aggregates (CMS-TA).
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- Horak, J., et al.
(författare)
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Alpha-Viscosity Effects in Slender Tori
- 2012
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Ingår i: Publications of the Astronomical Society of Japan. - 0004-6264. ; 64:4
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Tidskriftsartikel (refereegranskat)abstract
- We explore effects of the Shakura-Sunyaev alpha-viscosity on the dynamics and oscillations of slender tori. We start with a slow secular evolution of the torus. We show that the angular-momentum profile approaches the Keplerian one on a timescale longer than a dynamical one by a factor on the order of 1/alpha. We then focus our attention on the oscillations of the torus. We discuss the effects of various angular-momentum distributions. Using a perturbation theory, we have found a rather general result that the high-order acoustic modes are damped by the viscosity, while the high-order inertial modes are enhanced. We calculate viscous growth rates for the lowest-order modes, and show that already the lowest-order inertial mode is unstable for less-steep angular-momentum profiles, or very close to the central gravitating object.
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- Straub, O., et al.
(författare)
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Modelling the black hole silhouette in Sagittarius A* with ion tori
- 2012
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 543
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Tidskriftsartikel (refereegranskat)abstract
- We calculate the "observed at infinity" image and spectrum of the accretion structure in Sgr A*, by modelling it as an optically thin, constant angular momentum ion torus in hydrodynamic equilibrium. The physics we consider includes a two-temperature plasma, a toroidal magnetic field, as well as radiative cooling by bremsstrahlung, synchrotron, and inverse Compton processes. Our relativistic model has the virtue of being fully analytic and very simple, depending only on eight tunable parameters: the black hole spin and the inclination of the spin axis to our line of sight, the torus angular momentum, the polytropic index, the magnetic to total pressure ratio, the central values of density and electron temperature, and the ratio of electron to ion temperatures. The observed image and spectrum are calculated numerically using the ray-tracing code GYOTO. Our results demonstrate that the ion torus model is able to account for the main features of the accretion structure surrounding Sgr A*. RAMOWICZ M, 1978, ASTRONOMY AND ASTROPHYSICS, V63, P221 RAMOWICZ MA, 1995, ASTROPHYSICAL JOURNAL, V438, PL37 RAMOWICZ MA, 1983, MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, V203, P323
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- Vincent, F. H., et al.
(författare)
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Spectral signature of oscillating slender tori surrounding Kerr black holes
- 2014
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 563
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Tidskriftsartikel (refereegranskat)abstract
- Context. Some microquasars exhibit millisecond quasi-periodic oscillations (QPO) that are most probably related to phenomena occuring in the immediate vicinity of central black holes. Oscillations of accretion tori have been proposed to model these QPOs. Aims. Here, we aim at determining the observable spectral signature of slender accretion tori surrounding Kerr black holes. We analyse the impact of the inclination and spin parameters on the power spectra. Methods. Ray-traced power spectra of slender tori oscillation modes are computed in the Kerr metric. Results. We show that the power spectral densities of oscillating tori are very sensitive to the inclination and spin parameters. This strong dependency of the temporal spectra on inclination and spin may lead to observable constraints of these parameters. Conclusions. This work goes a step further in the analysis of the oscillating torus QPO model. It is part of a long-term study that will ultimately lead to comparison with observed data.
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