| 1. |
- Forrest, ARR, et al.
(författare)
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A promoter-level mammalian expression atlas
- 2014
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 507:7493, s. 462-
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Fujita, S., et al.
(författare)
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Spatial and temporal variability of snow accumulation rate on the East Antarctic ice divide between Dome Fuji and EPICA DML
- 2011
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Ingår i: The Cryosphere. - : Copernicus GmbH. - 1994-0416 .- 1994-0424. ; 5:4, s. 1057-1081
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Tidskriftsartikel (refereegranskat)abstract
- To better understand the spatio-temporal variability of the glaciological environment in Dronning Maud Land (DML), East Antarctica, a 2800-km-long Japanese-Swedish traverse was carried out. The route includes ice divides between two ice-coring sites at Dome Fuji and EPICA DML. We determined the surface mass balance (SMB) averaged over various time scales in the late Holocene based on studies of snow pits and firn cores, in addition to radar data. We find that the large-scale distribution of the SMB depends on the surface elevation and continentality, and that the SMB differs between the windward and leeward sides of ice divides for strong-wind events. We suggest that the SMB is highly influenced by interactions between the large-scale surface topography of ice divides and the wind field of strong-wind events that are often associated with high-precipitation events. Local variations in the SMB are governed by the local surface topography, which is influenced by the bedrock topography. In the eastern part of DML, the accumulation rate in the second half of the 20th century is found to be higher by similar to 15% than averages over longer periods of 722 a or 7.9 ka before AD 2008. A similar increasing trend has been reported for many inland plateau sites in Antarctica with the exception of several sites on the leeward side of the ice divides.
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| 3. |
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| 4. |
- Fan, G. W., et al.
(författare)
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Structure of 8Li from a reaction cross-section measurement
- 2014
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Ingår i: Phys. Rev. C. - American Physical Society. ; 90, s. 044321-
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Tidskriftsartikel (refereegranskat)abstract
- We have precisely measured reaction cross sections (σR) for 8Li using 9Be, 12C, 27Al, and proton targets at intermediate energies by the transmission method. From the energy dependence of the σR including the high energy data, the density distribution of 8Li was deduced through a modified Glauber model. It is shown that 8Li has a shorter tail structure in the density as compared with that of 8B and the matter radius of 8Li is similar to those of the other nonhalo Li isotopes. The result is consistent with the previous experiments that there is a tendency for 8Li to be a skin nucleus.
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| 5. |
- Fujita, S., et al.
(författare)
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Radar diagnosis of the subglacial conditions in Dronning Maud Land, East Antarctica
- 2012
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Ingår i: The Cryosphere. - : Copernicus GmbH. - 1994-0416 .- 1994-0424. ; 6:5, s. 1203-1219
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Tidskriftsartikel (refereegranskat)abstract
- In order to better understand the spatial distribution of subglacial environments, ground-based radar profiling data were analyzed for a total distance of similar to 3300 km across Dronning Maud Land, East Antarctica. The relationship between geometrically corrected bed returned power [Pc bed] dB in decibels and ice thickness H was examined. When H is smaller than a critical value that varies according to location, [P-bed(c)](dB) tends to decrease relatively smoothly with increasing H, which is explicable primarily by the cumulative effect of dielectric attenuation within the ice. However, at locations where H is larger than the critical H values, anomalous increases and fluctuations in [P-bed(c)](dB) were observed, regardless of the choice of radar frequency or radar-pulse width. In addition, the amplitude of the fluctuations often range 10 similar to 20 dB. We argue that the anomalous increases are caused by higher bed reflectivity associated with the existence of subglacial water. We used these features to delineate frozen and temperate beds. Approximately two-thirds of the investigated area was found to have a temperate bed. The beds of the inland part of the ice sheet tend to be temperate, with the exception of subglacial high mountains. In contrast, the beds of coastal areas tend to be frozen, with the exception of fast-flowing ice on the subglacial lowland or troughs. We argue that this new analytical method can be applied to other regions.
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| 6. |
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| 7. |
- Chu, X., et al.
(författare)
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Intracellular Drug Concentrations and Transporters : Measurement, Modeling, and Implications for the Liver
- 2013
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Ingår i: Clinical Pharmacology and Therapeutics. - : Springer Science and Business Media LLC. - 0009-9236 .- 1532-6535. ; 94:1, s. 126-141
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Forskningsöversikt (refereegranskat)abstract
- Intracellular concentrations of drugs and metabolites are often important determinants of efficacy, toxicity, and drug interactions. Hepatic drug distribution can be affected by many factors, including physicochemical properties, uptake/efflux transporters, protein binding, organelle sequestration, and metabolism.This white paper highlights determinants of hepatocyte drug/metabolite concentrations and provides an update on model systems, methods, and modeling/simulation approaches used to quantitatively assess hepatocellular concentrations of molecules. The critical scientific gaps and future research directions in this field are discussed.
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| 8. |
- Godoy, Patricio, et al.
(författare)
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
- 2013
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Ingår i: Archives of Toxicology. - : Springer Science and Business Media LLC. - 0340-5761 .- 1432-0738. ; 87:8, s. 1315-1530
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Forskningsöversikt (refereegranskat)abstract
- This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, as well as hepatic metabolism, is controlled by a set of nuclear receptors (including PXR, CAR, HNF-4 alpha, FXR, LXR, SHP, VDR and PPAR) and signaling pathways. When isolating liver cells, some pathways are activated, e.g., the RAS/MEK/ERK pathway, whereas others are silenced (e.g. HNF-4 alpha), resulting in up- and downregulation of hundreds of genes. An understanding of these changes is crucial for a correct interpretation of in vitro data. The possibilities and limitations of the most useful liver in vitro systems are summarized, including three-dimensional culture techniques, co-cultures with non-parenchymal cells, hepatospheres, precision cut liver slices and the isolated perfused liver. Also discussed is how closely hepatoma, stem cell and iPS cell-derived hepatocyte-like-cells resemble real hepatocytes. Finally, a summary is given of the state of the art of liver in vitro and mathematical modeling systems that are currently used in the pharmaceutical industry with an emphasis on drug metabolism, prediction of clearance, drug interaction, transporter studies and hepatotoxicity. One key message is that despite our enthusiasm for in vitro systems, we must never lose sight of the in vivo situation. Although hepatocytes have been isolated for decades, the hunt for relevant alternative systems has only just begun.
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| 9. |
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| 10. |
- Togashi, N., et al.
(författare)
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Single crystal structure analysis of the Se-incorporated mordenite, coupled with the anomalous X-ray scattering
- 2011
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Ingår i: Solid State Sciences. - : Elsevier BV. - 1293-2558 .- 1873-3085. ; 13, s. 684-690
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Tidskriftsartikel (refereegranskat)abstract
- Mordenite has one-dimensional 8-ring and 12-ring channels running parallel to the c-axis and Se molecules were successfully incorporated into the mordenite channels through a vapor phase after dehydration. The structure of the Se-incorporated mordenite was analyzed by single crystal X-ray diffraction coupled with anomalous X-ray scattering (AXS). The AXS analysis confirmed the Se distribution in the 12-ring channels only, by analyzing the intensity contrast observed at the Se K-absorption edge. And this environmental structure information allows us to improve the structural analysis of the ordinary single crystal X-ray diffraction. The present analysis suggested that Se molecules such as an infinite chain and its fragments were preferentially formed in the 12-ring channels together with the feasible bonding of Se-Na pairs. The location and probability of Na in the 12-ring channels are suggested to be considered as important factors affecting the probability of Se chain and its fragmentation.
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