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- Purcell, Shaun M., et al.
(författare)
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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
- 2009
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 460:7256, s. 748-752
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Tidskriftsartikel (refereegranskat)abstract
- Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%(1,2). We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.
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- Ekholm, Tobias, et al.
(författare)
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Legendrian contact homology in P x R
- 2007
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Ingår i: Transactions of the American Mathematical Society. - 0002-9947 .- 1088-6850. ; 359:7, s. 3301-3335
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Tidskriftsartikel (refereegranskat)abstract
- A rigorous foundation for the contact homology of Legendrian submanifolds in a contact manifold of the form P × ℝ, where P is an exact symplectic manifold, is established. The class of such contact manifolds includes 1-jet spaces of smooth manifolds. As an application, contact homology is used to provide (smooth) isotopy invariants of submanifolds of ℝn and, more generally, invariants of self transverse immersions into ℝn up to restricted regular homotopies. When n = 3, this application is the first step in extending and providing a contact geometric underpinning for the new knot invariants of Ng.
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- Zhang, Xuanjun, et al.
(författare)
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Aggregation dependent S1 and S2 dual emissions of thiophene-acrylonitrile-carbazole oligomer
- 2008
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Ingår i: Crystal Growth & Design. - : American Chemical Society (ACS). - 1528-7483 .- 1528-7505. ; 8:7, s. 2543-2546
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Tidskriftsartikel (refereegranskat)abstract
- Dual emissions from S1 (blue region) and S2 (UV region) states of a chromophore with donor−acceptor structure were observed at room temperature. The photophysical properties of the chromophore depend critically on the packing of the molecules. The molecule exhibits weak S1 emission and strong S2 emission; however, when it undergoes solid aggregation, the S1 emission is enhanced while the S2 emission is quenched. The H-packing (face-to-face packing) of the molecules is revealed as the key factor for this interesting aggregation-dependent dual emission.
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