| 1. |
- Carninci, P, et al.
(författare)
-
The transcriptional landscape of the mammalian genome
- 2005
-
Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 309:5740, s. 1559-1563
-
Tidskriftsartikel (refereegranskat)abstract
- This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5′ and 3′ boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
|
|
| 2. |
- Kabir, S E, et al.
(författare)
-
Triiron and triruthenium carbonyl clusters bearing bridging long chain diphosphine and capping chalcogenido ligands
- 2005
-
Ingår i: Journal of Cluster Science. - : Springer Science and Business Media LLC. - 1040-7278 .- 1572-8862. ; 16:1, s. 93-110
-
Tidskriftsartikel (refereegranskat)abstract
- Treatment of Ru-3(CO)(12) with dpphSe(2) (dpph = 1,6-bis(diphenylphosphino)-hexane) in refluxing toluene in the presence of Me3NO afforded two new compounds, Ru-3(CO)(7)(mu-CO)(mu(3)-Se)(mu-dpph) (1) and Ru-3(CO)(7)(mu(3)-Se)(2)(mu-dpph) (2). A similar reaction of Ru-3(CO)(12) with dpppeSe(2)(dpppe=1,5-bis(diphenylphosphino)pentane) gave exclusively Ru-3(CO)(7)(mu(3)-Se)(2)(mu-dpppe) (3). Treatment of Ru-3(CO)(12) with dpphS(2) and dpppeS(2) at 110 degrees C in the presence of Me3NO afforded Ru-3(CO)(7)(mu(3)-S)(2)(mu-dpph) (4) and Ru-3(CO)(7)(mu(3)-S)(2)(mu-dpppe) (5), respectively. Reactions of Fe-3(CO)(12) with dpphSe(2) and dpppeSe(2), under identical conditions, afforded Fe-3(CO)(7)(mu(3)-Se)(2)(mu-dpph) (6) and Fe-3(CO)(7)(mu(3)-Se)(2)(mu-dpppe) (7), respectively. Compounds 1-7 were characterized spectroscopically and the molecular structures of compounds 1-4 were determined by single crystal X-ray crystallography. The core of 1 contains an equilateral triangle of ruthenium atoms with one capping selenium, one bridging dpph, one doubly bridging carbonyl and seven terminal carbonyl ligands. Complexes 2-4 have a square-pyramidal structure with two metal and two chalcogenide atoms alternating in the basal plane and the third metal atom at the apex of the pyramid, and belong to the family of well-known nido clusters with seven skeletal electron pairs.
|
|
| 3. |
- Hore, Samar Kumar, et al.
(författare)
-
Detecting arsenic-related skin lesions : Experiences from a large community-based survey in Bangladesh
- 2007
-
Ingår i: International Journal of Environmental Health Research. - : Informa UK Limited. - 0960-3123 .- 1369-1619. ; 17:2, s. 141-149
-
Tidskriftsartikel (refereegranskat)abstract
- A cross-sectional survey was conducted in Matlab, Bangladesh, to determine the prevalence of skin lesions (a three-step procedure) associated with arsenic exposure and discuss validity and feasibility in relation to recommended screening algorithms. Cases with skin lesions were identified by screening above 4 years of age (n = 166,934). Trained field teams conducted a careful house-to-house screening and identified 1682 individuals with skin lesions, who were referred to physicians for confirmation. Physicians diagnosed 579 cases as probable and documented all these with digital photographs. Two experts inspected all photographs for consensus agreement that was reached for 504 cases. Using the experts' opinions as reference, the positive predictive value of the physicians' diagnosis was 87% (male = 82% vs. female = 94%; p < 0.01). The physicians had difficulties in separating arsenic-induced keratosis from differential diagnoses, while probability for correct diagnosis was high for arsenic-related pigmentation changes. Including information on current arsenic concentration in drinking water (which was masked at time of skin examination) or urine in the diagnostic algorithm should have increased the number of false negative cases. In the present transition of drinking water sources these markers of current exposure levels provide no information on past exposure. A 2 - 3 step procedure with house-to-house screening and clinic-based confirmation of arsenic-induced skin lesions is a feasible approach. Information on arsenic concentration in current water sources or in urine should not have improved the precision in the diagnosis. These results may have policy implications for community screening of arsenic-related skin lesions in Bangladesh and elsewhere.
|
|
| 4. |
|
|
| 5. |
|
|
