SYNTHETIC AND CONFORMATIONAL STUDIES OF BRANCHED AND LARIAT RNAS - MODELING THE LARIAT FORMED IN THE SPLICING REACTION - A CRITICAL-REVIEW

• The formation of lariat RNAs in eukaryotes plays a central role in the transmission of genetic information into protein products through the synthesis of the processed RNA. The biomimetic synthetic models (branched and lariat RNGs) of the lariat RNA intro

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BRANCHED RNA; LARIAT RNA; SPLICING REACTION; PRE-MESSENGER-RNA; SOLID-PHASE SYNTHESIS; MHZ NMR-SPECTROSCOPY; 3'-5' PHOSPHODIESTER LINKAGES; SITE-SPECIFIC MODIFICATION; CHEMICAL SYNTHESIS; GROUP-II; CYCLIC OLIGODEOXYRIBONUCLEOTIDES; REGIOSPECIFIC SYNTHESIS

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