| 1. |
- Klimkowska, Agata, et al.
(författare)
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Are we restoring functional fens? : The outcomes of restoration projects in fens re-analysed with plant functional traits
- 2019
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Ingår i: PLOS ONE. - : PUBLIC LIBRARY SCIENCE. - 1932-6203. ; 14:4
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Tidskriftsartikel (refereegranskat)abstract
- In peatland restoration we often lack an information whether re-established ecosystems are functionally similar to non-degraded ones. We re-analysed the long-term outcomes of restoration on vegetation and plant functional traits in 38 European fens restored by rewetting (18 sites) and topsoil removal (20 sites). We used traits related to nutrient acquisition strategies, competitiveness, seed traits, and used single- and multi-trait metrics. A separate set of vegetation records from near-natural fens with diverse plant communities was used to generate reference values to aid the comparisons. We found that both restoration methods enhanced the similarity of species composition to non-degraded systems but trait analysis revealed differences between the two approaches. Traits linked to nutrient acquisition strategies indicated that topsoil removal was more effective than rewetting. After topsoil removal competitive species in plant communities had decreased, while stress-tolerant species had increased. A substantial reduction in nutrient availability ruled out the effect of initial disturbance. An ability to survive and grow in anoxic conditions was enhanced after restoration, but the reference values were not achieved. Rewetting was more effective than topsoil removal in restricting variation in traits values permitted in re-developing vegetation. We found no indication of a shift towards reference in seed traits, which suggested that dispersal constraint and colonization deficit can be a widespread phenomena. Two functional diversity indices: functional richness and functional dispersion showed response to restoration and shifted values towards reference mires and away from the degraded systems. We concluded that targeting only one type of environmental stressor does not lead to a recovery of fens, as it provides insufficient level of stress to restore a functional ecosystem. In general, restoration efforts do not ensure the re-establishment and long-term persistence of fens. Restoration efforts result in recovery of fen ecosystems, confirmed with our functional trait analysis, although more rigid actions are needed for restoring fully functional mires, by achieving high and constant levels of anoxia and nutrient stresses.
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| 2. |
- Albertsson-Lindblad, Alexandra, et al.
(författare)
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Lenalidomide-bendamustine-rituximab in patients older than 65 years with untreated mantle cell lymphoma
- 2016
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 128:14, s. 1814-1820
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Tidskriftsartikel (refereegranskat)abstract
- For elderly patients with mantle cell lymphoma (MCL), there is no defined standard therapy. In this multicenter, open-label phase 1/2 trial, we evaluated the addition of lenalidomide (LEN) to rituximab-bendamustine (R-B) as first-line treatment for elderly patients with MCL. Patients >65 years with untreated MCL, stages II-IV were eligible for inclusion. Primary end points were maximally tolerable dose (MTD) of LEN and progression-free survival (PFS). Patients received 6 cycles every four weeks of L-B-R (L D1-14, B 90 mg/m(2) IV, days 1-2 and R 375 mg/m(2) IV, day 1) followed by single LEN (days 1-21, every four weeks, cycles 7-13). Fifty-one patients (median age 71 years) were enrolled from 2009 to 2013. In phase 1, the MTD of LEN was defined as 10 mg in cycles 2 through 6, and omitted in cycle 1. After 6 cycles, the complete remission rate (CRR) was 64%, and 36% were MRD negative. At a median follow-up time of 31 months, median PFS was 42 months and 3-year overall survival was 73%. Infection was the most common nonhematologic grade 3 to 5 event and occurred in 21 (42%) patients. Opportunistic infections occurred in 3 patients: 2 Pneumocystis carinii pneumonia and 1 cytomegalovirus retinitis. Second primary malignancies (SPM) were observed in 8 patients (16%). LEN could safely be combined with R-B when added from the second cycle in patients with MCL, and was associated with a high rate of CR and molecular remission. However, we observed a high degree of severe infections and an unexpected high number of SPMs, which may limit its use. This trial is registered at www.Clinicaltrials.gov as #NCT00963534.
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| 3. |
- Albertsson-Lindblad, Alexandra, et al.
(författare)
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Lenalidomide-bendamustine-rituximab in untreated mantle cell lymphoma > 65 years, the Nordic Lymphoma Group phase I+II trial NLG-MCL4
- 2016
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 128:14, s. 1814-1820
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Tidskriftsartikel (refereegranskat)abstract
- For elderly patients with mantle cell lymphoma (MCL), there is no defined standard therapy. In this multicenter open-label phase I/II trial we evaluated the addition of lenalidomide (LEN) to rituximab-bendamustine (R-B) as first-line treatment to elderly MCL patients. Patients >65 years with untreated MCL, stage II-IV were eligible for inclusion. Primary endpoints were maximally tolerable dose (MTD) of LEN, and progression-free survival (PFS). Patients received six cycles q4w of L-B-R (L D1-14, B 90 mg/m(2) iv D1-2 and R 375 mg/m(2) iv D1) followed by single LEN (D1-21, q4w, cycles 7-13). 51 patients (median age 71 years) were enrolled 2009-2013. In phase I, the MTD of LEN was defined as 10 mg in cycles 2-6, and omitted in cycle 1. After six cycles, the complete remission rate (CRR) was 64% and 36% were MRD negative. At a median follow-up time of 31 months, median PFS was 42 months and 3 year overall survival was 73%. Infection was the most common non-hematological grade 3-5 event and occurred in 21 (42%) patients. Opportunistic infections occurred in three patients; 2 PCP and 1 CMV retinitis. Second primary malignancies (SPM) were observed in eight patients (16%). LEN could safely be combined with R-B, when added from the second cycle in patients with MCL, and was associated with a high rate of CR and molecular remission. However, we observed a high degree of severe infections and an unexpected high number of SPMs which may limit its use. http://clinicaltrials.gov: NCT00963534.
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| 5. |
- Bender, Anke, et al.
(författare)
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A Review of Methods and Models for Environmental Monitoring of Marine Renewable Energy
- 2017
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Ingår i: Proceedings of the 12th European Wave and Tidal Energy Conference. - : EWTEC.
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Konferensbidrag (refereegranskat)abstract
- A continued expansion of the marine renewable energy sector will result in an increased demand in monitoring the natural marine environment. This may be due to a basic scientific interest but is foremost linked to the requirement of pre- and post-construction studies in relation to environmental impact assessments and consenting processes for marine renewable energy projects. With focus on wave and tidal power, but without attempting to provide a comprehensive list, we review methods, technologies and other scientific tools used for monitoring and predicting possible impacts from marine energy installations, on both population and behavioural levels. This includes traditional methods such as fishing gear, like nets and cages, modern technologies such as platforms with multi parameter equipment and the use of deterministic models. This paper is intended to serve as an overview for technology developers as well as authorities, regulators and decision makers with interests in general techniques, and naturally for scientists and consultants commonly being executors of studies and monitoring programs. By giving relevant and up to date references this paper may also be useful for finding more detailed information on study methods and variants. Finally, we give recommendations on where development of technologies is needed in order to face future requirements.
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| 6. |
- Bender, Anke, et al.
(författare)
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Effects from wave power generators on the distribution of two sea pen species on the Swedish west coast
- 2019
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Konferensbidrag (refereegranskat)abstract
- Global electricity demand doubled between 1990 and 2016 and several countries are planning for a significant increase in offshore renewable energies along the European coast. In 2015 renewable energy accounted for more than half of the new generating capacity installed in the power sector worldwide. These activities bring up an increased interest about possible environmental impacts or additional values of the new technologies. The Wave Energy Park "Sotenäs Project" is located on the west coast of Sweden, 120 km north of Gothenburg, and was the site for environmental impact studies from wave energy generators on two sea pen species, Virgularia mirabilis (Müller, 1776) and Pennatula phosphorea (Linnaeus, 1758). Sea pens and burrowing mega fauna communities are designated threatened or declining habitats or species by the OSPAR convention. Investigations of those taxa in relation to marine renewable energies are thereby both interesting and important. A ROV aided seabed survey in the wave power park and respective control areas were primarily conducted to assess Nephrops norvegicus (Linnaeus, 1758) abundance and video footages were used to compare the abundance of the two sea pen species within the same area. Preliminary results show a significant difference between the transects and years. However, a clear increased number of individuals inside the wave power park for the two sea pen species compared to the control transects were not identified. Long-term observations and complementary studies are necessary in order to draw firm conclusions.
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| 7. |
- Bender, Anke, et al.
(författare)
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Effects of Wave Energy Generators on Nephrops Norvegicus
- 2018
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Ingår i: AWTEC 2018 Proceedings.
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Konferensbidrag (refereegranskat)abstract
- Wave energy research is primarily focused on the technical developments of energy conversion but the parallel evaluation of environmental effects related to wave energy is also essential and reflects sustainable development of renewable energy. At the west coast of Sweden, 120 km north of Gothenburg, the Wave Energy Park “Sotenäs Project” is located. This area has been the location of environmental impact studies from wave energy generators on the macro crustacean species Nephrops norvegicus (Linnaeus, 1758), the Norway lobster. The Norway lobster is an ecologically as well as economically important species in Sweden and across Europe. The aim of this preliminary study was to detect possible positive or negative effects on numbers of individuals by the presence of the wave energy generators and the created “no take” zone. For that purpose, ROV aided seabed recordings of the characteristic Norway lobster burrow entrances were conducted inside the Wave Energy Park and respective control areas in 2016 and 2017. Preliminary results do not show a clear distinct result between the different transects and years. Long-term observations and complementary studies are necessary to draw conclusions and outweigh extreme and rare events of annual one-time samplings.
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