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- Castano, J. P., et al.
(författare)
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Gastrointestinal neuroendocrine tumors (NETs) : new diagnostic and therapeutic challenges
- 2014
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Ingår i: Cancer Metastasis Review. - : Springer Science and Business Media LLC. - 0167-7659 .- 1573-7233. ; 33:1, s. 353-359
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Forskningsöversikt (refereegranskat)abstract
- This paper summarizes the current understanding of the biology of somatostatin receptor (sst), role of immunotherapy in neuroendocrine tumor (NET), new agents for PPRT, and methods to assess response and clinical benefit in NET. One of the most interesting aspects of sst biology is the recent discovery of truncated variants of the sst5 receptor subtype with unique tissue distribution and response to somatostatin (SST). These truncated receptors are associated with bad patient prognosis, decreased response to SST analogs, and may be new targets for diagnoses and treatment. IFN remains a cost-effective agent, particularly in classic mid gut carcinoids, and there is interest to continue examining immunotherapy's in this disease. PRRT remains a key strategy for treatment and imaging. In addition to the classic agents, there are a series of new agents targeting other receptors such as the incretin receptors (GLP-1R; GIPR) and other G-protein coupled receptors with great potential. With regards to therapy monitoring, the most commonly used criteria are Response Criteria Evaluation in Solid Tumors (RECIST). However, for different reasons, these criteria are not very useful in NET. Incorporation of other criteria such as Choi as well as functional imaging assessment with PET would be of great interest in this area.
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- Fritzson, Ingela, et al.
(författare)
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N-Substituted salicylamides as selective malaria parasite dihydroorotate dehydrogenase inhibitors
- 2011
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Ingår i: MedChemComm. - : Royal Society of Chemistry (RSC). - 2040-2511 .- 2040-2503. ; 2:9, s. 895-898
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Tidskriftsartikel (refereegranskat)abstract
- In our continuing program to develop Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors, a series of N-substituted salicylamides were synthesized and their ability to selectively inhibit PfDHODH was examined. The synthetic program was based on 2-hydroxy-N-(2-phenylethyl)benzamide (1) that weakly inhibits both PfDHODH and human DHODH (hDHODH). Structure activity relationships were examined for developing derivatives. Selective PfDHODH inhibitors with improved potency were obtained by introducing a 2,2-diphenylethyl substitution on the salicylamidic nitrogen. Biological activity of the most potent compounds was confirmed on parasite infected cells in vitro.
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- Lundblad, Henrik, et al.
(författare)
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Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame?
- 2014
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Ingår i: Scientific World Journal. - : Hindawi Publishing Corporation. - 1537-744X .- 2356-6140. ; 2014, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Monitoring and quantifying bone remodeling are of interest, for example, in correction osteotomies, delayed fracture healing pseudarthrosis, bone lengthening, and other instances. Seven patients who had operations to attach an Ilizarov-derived Taylor Spatial Frame to the tibia gave informed consent. Each patient was examined by (NaF)-F-18 PET/CT twice, at approximately six weeks and three months after the operation. A validated software tool was used for the following processing steps. The first and second CT volumes were aligned in 3D and the respective PET volumes were aligned accordingly. In the first PET volume spherical volumes of interest (VOIs) were delineated for the crural fracture and normal bone and transferred to the second PET volume for SUVmax evaluation. This method potentially provides clinical insight into questions such as, when has the bone remodeling progressed well enough to safely remove the TSF? and when is intervention required, in a timelier manner than current methods? For example, in two patients who completed treatment, the SUVmax between the first and second PET/CT examination decreased by 42% and 13%, respectively. Further studies in a larger patient population are needed to verify these preliminary results by correlating regional (NaF)-F-18 PET measurements to clinical and radiological findings.
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- Sandström, Hans Eric, et al.
(författare)
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100% FTTx coverage is economically feasible even in rural <1 people/km 2 areas
- 2012
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Ingår i: Networks and Optical Communications (NOC), 2012 17th European Conference on. - : IEEE. - 9781467309516
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Konferensbidrag (refereegranskat)abstract
- Fiber to the end-user (FTTx) has long been considered to be too expensive to be deployed to cover all end users especially those living in the far rural areas. The conclusion after working with some municipalities in Jamtland is now that FTTx is both technically and economically feasible. The architecture tested is an IP-Only broadband network capable of carrying end-user services up to 10/100Gbps to any point in the network. Building such a broadband infrastructure, is feasible mostly due to the fact that cost of standard IP-network components are diminishing and by utilizing novel network designs made possible because the limitations of the old Telecom infrastructure no longer apply and lastly that the take rate of permanent households is close to 100% due to the fact that the copper networks is removed.
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