| 1. |
|
|
| 2. |
- Billström, Emma, et al.
(author)
-
Socioeconomic characteristics, housing conditions and criminal offences among women with cervical neoplasia
- 2013
-
In: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 92:8, s. 888-894
-
Journal article (peer-reviewed)abstract
- Objective. To investigate the association between cervical neoplasia and socioeconomic factors, housing conditions and criminal offences. Design. Longitudinal observational study. Setting. Falun county hospital, Sweden. Population. A total of 1331 women diagnosed with cervical intraepithelial neoplasia I-III or cervical cancer between 1967 and 1978 were compared with 2604 age-matched controls from the same geographical area in Sweden. Methods. The Population and Housing Censuses were used for information about civil status, education, housing conditions, employment and socioeconomic status. The Swedish Register of Conviction Decisions was used to access information on criminal offences. Main outcome measures. Socioeconomic status, housing conditions, criminal offences. Results. Women with cervical neoplasia had a lower socioeconomic status and a lower educational level than their age-matched controls. They were more often divorced and did not own their home as often as controls. A significant association with criminal offences was observed, and it persisted after adjustment for socioeconomic status. Differences in socioeconomic factors between women with cervical neoplasia and their controls had not diminished in the younger, compared with the older, part of the study population. Conclusions. The results indicate that women with cervical neoplasia belong to a socioeconomically disadvantaged group. Furthermore, the study provides information about an association with criminal offences.
|
|
| 3. |
|
|
| 4. |
- Kallak, Theodora Kunovac, 1985-, et al.
(author)
-
Aromatase inhibitors affect vaginal proliferation and steroid hormone receptors
- 2014
-
In: Menopause. - : Lippincott Williams & Wilkins. - 1072-3714 .- 1530-0374. ; 21:4, s. 383-390
-
Journal article (peer-reviewed)abstract
- Objective: Women with breast cancer who are treated with aromatase inhibitors often experience vaginal atrophy symptoms and sexual dysfunction. This work aims to study proliferation and the presence and distribution of steroid hormone receptors in vaginal biopsies in relation to vaginal atrophy and vaginal pH in women with breast cancer who are on adjuvant endocrine treatment and in healthy postmenopausal women.Methods: This is a cross-sectional study that compares postmenopausal aromatase inhibitor-treated women with breast cancer (n = 15) with tamoxifen-treated women with breast cancer (n = 16) and age-matched postmenopausal women without treatment (n = 19) or with vaginal estrogen therapy (n = 16). Immunohistochemistry was used to study proliferation and steroid hormone receptor staining intensity. Data was correlated with estrogen and androgen levels, vaginal atrophy scores, and vaginal pH.Results: Aromatase inhibitor-treated women had a lower grade of proliferation, weaker progesterone receptor staining, and stronger androgen receptor staining, which correlated with plasma estrone levels, vaginal atrophy scores, and vaginal pH.Conclusions: Women with aromatase inhibitor-treated breast cancer exhibit reduced proliferation and altered steroid hormone receptor staining intensity in the vagina, which are related to clinical signs of vaginal atrophy. Although these effects are most probably attributable to estrogen suppression, a possible local inhibition of aromatase cannot be ruled out.
|
|
| 5. |
- Larson, Magnus, et al.
(author)
-
Impacts of Typhoons on the Vietnamese Coastline: A Case Study of Hai Hau Beach and Ly Hoa Beach.
- 2014
-
In: Coastal Disasters and Climate Change in Vietnam: Engineering and Planning Perspectives. - 9780128000076 ; , s. 17-42
-
Book chapter (peer-reviewed)abstract
- On average, five to six typhoons hit the Vietnamese coastline every year, often causing great destruction and many deaths as they move in over land. When a typhoon passes it brings high water levels, large waves, strong winds, and heavy rainfall. The high water levels, in combination with large waves, may induce overtopping and erosion of dikes and sand dunes. This can lead to flooding and saltwater intrusion to farmland, with water masses destroying crops, and in extreme cases can result in the loss of life and property. The main objectives of the present study were to quantify the impact of typhoons on the Vietnamese coastline with respect to overtopping and erosion, and to assess future effects for people living in these areas, especially in view of climate change. The study of the consequences of typhoon attacks was limited to two different but representative areas along the Vietnamese coastline: Hai Hau Beach in Nam Dinh Province and Ly Hoa Beach in Quang Binh Province. The former study area includes man-made dikes and the latter one natural sand dunes.
|
|
| 6. |
- Larsson, Emma, et al.
(author)
-
Expression of PaNAC01, a Picea abies CUP-SHAPED COTYLEDON orthologue, is regulated by polar auxin transport and associated with differentiation of the shoot apical meristem and formation of separated cotyledons
- 2012
-
In: Annals of Botany. - : Oxford University Press (OUP). - 0305-7364 .- 1095-8290. ; 110, s. 923-934
-
Journal article (peer-reviewed)abstract
- During embryo development in most gymnosperms, the establishment of the shoot apical meristem (SAM) occurs concomitantly with the formation of a crown of cotyledons surrounding the SAM. It has previously been shown that the differentiation of cotyledons in somatic embryos of Picea abies is dependent on polar auxin transport (PAT). In the angiosperm model plant, Arabidopsis thaliana, the establishment of cotyledonary boundaries and the embryonal SAM is dependent on PAT and the expression of the CUP-SHAPED COTYLEDON (CUC) genes, which belong to the large NAC gene family. The aim of this study was to characterize CUC-like genes in a gymnosperm, and to elucidate their expression during SAM and cotyledon differentiation, and in response to PAT.Sixteen Picea glauca NAC sequences were identified in GenBank and deployed to different clades within the NAC gene family using maximum parsimony analysis and Bayesian inference. Motifs conserved between angiosperms and gymnosperms were analysed using the motif discovery tool MEME. Expression profiles during embryo development were produced using quantitative real-time PCR. Protein conservation was analysed by introducing a P. abies CUC orthologue into the A. thaliana cuc1cuc2 double mutant.Two full-length CUC-like cDNAs denoted PaNAC01 and PaNAC02 were cloned from P. abies. PaNAC01, but not PaNAC02, harbours previously characterized functional motifs in CUC1 and CUC2. The expression profile of PaNAC01 showed that the gene is PAT regulated and associated with SAM differentiation and cotyledon formation. Furthermore, PaNAC01 could functionally substitute for CUC2 in the A. thaliana cuc1cuc2 double mutant.The results show that CUC-like genes with distinct signature motifs existed before the separation of angiosperms and gymnosperms approx. 300 million years ago, and suggest a conserved function between PaNAC01 and CUC1/CUC2.
|
|
| 7. |
- Mähler, Emma, et al.
(author)
-
Detecting small liver tumors with In-111-Pentetreotide SPECT-A Collimator study based on Monte Carlo simulations
- 2012
-
In: IEEE Transactions on Nuclear Science. - : IEEE. - 0018-9499 .- 1558-1578. ; 59:1, s. 47-53
-
Journal article (peer-reviewed)abstract
- In In-111- pentetreotide single-photon emission computed tomography (SPECT), the tumor-to-background-uptake ratio is generally high. The noise is, however, also usually on a high level, and in combination with the low spatial resolution of SPECT, this may lead to difficulties in the detection of small tumors. This is especially the case in regions with a relatively high background activity, such as in the liver, which is a common region for somatostatin-positive metastases. Visually detecting the small tumors is important for a successful treatment of the cancer disease. In this paper, we compare three different parallel-hole collimators for In-111-pentetreotide SPECT regarding contrast as a function of image noise for a phantom simulating small tumors in liver background. The corresponding contrast-to-noise ratios are also presented. All raw-data projections are produced using Monte Carlo simulations. The collimators are of type low-energy general-purpose (LEGP), extended LEGP (ELEGP), and medium-energy general-purpose (MEGP). Reconstructions were performed with OSEM both with and without model-based compensation. Of the investigated collimators, the ELEGP collimator proved to be the most optimal for the smallest tumors, both with and without model-based compensation included in the reconstruction. It is also shown that model-based compensation outperforms the conventional reconstruction technique.
|
|
