| 1. |
- Eckerle, S., et al.
(författare)
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Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas : insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma
- 2009
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Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 23:11, s. 2129-2138
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Tidskriftsartikel (refereegranskat)abstract
- Anaplastic large cell lymphoma (ALCL) is a main type of T-cell lymphomas and comprises three distinct entities: systemic anaplastic lymphoma kinase (ALK) positive, systemic ALK(-) and cutaneous ALK(-) ALCL (cALCL). Little is known about their pathogenesis and their cellular origin, and morphological and immunophenotypical overlap exists between ALK(-) ALCL and classical Hodgkin lymphoma (cHL). We conducted gene expression profiling of microdissected lymphoma cells of five ALK(+) and four ALK(-) systemic ALCL, seven cALCL and sixteen cHL, and of eight subsets of normal T and NK cells. The analysis supports a derivation of ALCL from activated T cells, but the lymphoma cells acquired a gene expression pattern hampering an assignment to a CD4(+), CD8(+) or CD30(+) T-cell origin. Indeed, ALCL display a down-modulation of many T-cell characteristic molecules. All ALCL types show significant expression of NFkappaB target genes and upregulation of genes involved in oncogenesis (e.g. EZH2). Surprisingly, few genes are differentially expressed between systemic and cALCL despite their different clinical behaviour, and between ALK(-) ALCL and cHL despite their different cellular origin. ALK(+) ALCL are characterized by expression of genes regulated by pathways constitutively activated by ALK. This study provides multiple novel insights into the molecular biology and pathogenesis of ALCL.
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| 2. |
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| 3. |
- Gulbinas, V., et al.
(författare)
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Charge carrier photogeneration and recombination in ladder-type poly(para-phenylene): Interplay between impurities and external electric field
- 2007
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Ingår i: Physical Review B (Condensed Matter and Materials Physics). - 1098-0121. ; 76:23
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Tidskriftsartikel (refereegranskat)abstract
- Charge carrier generation and decay in m-LPPP polymer films were examined by means of femtosecond transient absorption spectroscopy in the time window of 100 fs-15 ns. Two modes of polaron formation with distinct behavior were identified, impurity induced in the absence of an external electric field and electric field induced in pristine film. While field induced charge generation is relatively slow, occurring throughout the excited state lifetime, the rate of impurity induced charge generation is much faster and depends on excitation wavelength; it occurs on the several hundred femtosecond time scale under excitation within the main absorption band, but excitation into the red wing of the absorption band results in charge generation within less than 100 fs. Polaron decay through geminate electron-hole recombination occurs with widely distributed lifetimes, from similar to 0.8 ns to microseconds; the polarons characterized by the shortest decay time have a redshifted absorption spectrum (as compared to more long-lived polarons) and are attributed to tightly bound polaron pairs.
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| 4. |
- Gulbinas, V, et al.
(författare)
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Exciton diffusion and relaxation in methyl-substituted polyparaphenylene polymer films
- 2007
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 127:14
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Tidskriftsartikel (refereegranskat)abstract
- Exciton diffusion in ladder-type methyl-substituted polyparaphenylene film and solution was investigated by means of femtosecond pump-probe spectroscopy using a combined approach, analyzing exciton-exciton annihilation, and transient absorption depolarization properties. We show that the different views on the exciton dynamics offered by anisotropy decay and annihilation are required in order to obtain a correct picture of the energy transfer dynamics. Comparison of the exciton diffusion coefficient and exciton diffusion radius obtained for polymer film with the two techniques reveals that there is substantial short-range order in the film. Also in isolated chains there is considerable amount of order, as revealed from only partial anisotropy decay, which shows that only a small fraction of the excitons move to differently oriented polymer segments. It is further concluded that interchain energy transfer is faster than intrachain transfer, mainly as a result of shorter interchain distances between chromophoric units.
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| 5. |
- Gulbinas, V, et al.
(författare)
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Nonlinear exciton relaxation in ladder-type poly (para-phenylene)
- 2007
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Ingår i: Molecular Crystals and Liquid Crystals. - : Informa UK Limited. - 1543-5318 .- 1542-1406 .- 1563-5287. ; 467, s. 47-57
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Tidskriftsartikel (refereegranskat)abstract
- Nonlinear exciton relaxation processes, exciton-exciton annihilation, and amplified spontaneous emission were investigated in thin films of ladder-type poly(para-phenylene) under excitation by femtosecond light pulses. Both processes become apparent at similar excitation intensities, however their properties are very different. They cause different exciton relaxation kinetics and their intensity dependences are different.
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| 6. |
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