SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Superti Furga Giulio)
 

Search: WFRF:(Superti Furga Giulio) > (2015-2019) > Common Nodes of Vir...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis

Bösl, Korbinian (author)
Norwegian Univ Sci & Technol, Ctr Mol Inflammat Res, Trondheim, Norway;Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway
Ianevski, Aleksandr (author)
Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway
Than, Thoa T. (author)
Inst Pasteur Korea, Seongnam, South Korea
show more...
Andersen, Petter I. (author)
Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway
Kuivanen, Suvi (author)
Univ Helsinki, Dept Virol, Helsinki, Finland
Teppor, Mona (author)
Univ Tartu, Inst Technol, Tartu, Estonia
Zusinaite, Eva (author)
Univ Tartu, Inst Technol, Tartu, Estonia
Dumpis, Uga (author)
Pauls Stradins Clin Univ Hosp, Riga, Latvia
Vitkauskiene, Astra (author)
Lithuanian Univ Hlth Sci, Dept Lab Med, Kaunas, Lithuania
Cox, Rebecca J. (author)
Univ Bergen, Dept Clin Sci, Influenza Ctr, Bergen, Norway
Kallio-Kokko, Hannimari (author)
Univ Helsinki, Dept Virol & Immunol, Helsinki Univ Hosp, Helsinki, Finland
Bergqvist, Anders (author)
Uppsala universitet,Infektionsmedicin
Tenson, Tanel (author)
Univ Tartu, Inst Technol, Tartu, Estonia
Merits, Andres (author)
Univ Tartu, Inst Technol, Tartu, Estonia
Oksenych, Valentyn (author)
Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway
Björås, Magnar (author)
Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway
Anthonsen, Marit W. (author)
Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway
Shum, David (author)
Inst Pasteur Korea, Seongnam, South Korea
Kaarbö, Mari (author)
Oslo Univ Hosp, Dept Microbiol, Oslo, Norway
Vapalahti, Olli (author)
Univ Helsinki, Dept Vet Biosci, Helsinki, Finland
Windisch, Marc P. (author)
Inst Pasteur Korea, Seongnam, South Korea
Superti-Furga, Giulio (author)
Austrian Acad Sci, CeMM Res Ctr Mol Med, Vienna, Austria;Med Univ Vienna, Ctr Physiol & Pharmacol, Vienna, Austria
Snijder, Berend (author)
Swiss Fed Inst Technol, Inst Mol Syst Biol, Dept Biol, Zurich, Switzerland
Kainov, Denis (author)
Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway;Swiss Fed Inst Technol, Inst Mol Syst Biol, Dept Biol, Zurich, Switzerland
Kandasamy, Richard K. (author)
Norwegian Univ Sci & Technol, Ctr Mol Inflammat Res, Trondheim, Norway;Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway;Univ Oslo, Nord EMBL Partnership, Ctr Mol Med Norway NCMM, Oslo, Norway;Univ Massachusetts, Sch Med, Dept Med, Program Innate Immun,Div Infect Dis & Immunol, Worcester, MA 01655 USA
show less...
 (creator_code:org_t)
2019-10-04
2019
English.
In: Frontiers in Immunology. - : FRONTIERS MEDIA SA. - 1664-3224. ; 10
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways and evade innate immune response by modulating key host factors and signaling pathways. A collective view of these multiple studies could advance our understanding of virus-host interactions and provide new therapeutic perspectives for the treatment of viral diseases. Here, we performed an integrative meta-analysis to elucidate the 17 different host-virus interactomes. Network and bioinformatics analyses showed how viruses with small genomes efficiently achieve the maximal effect by targeting multifunctional and highly connected host proteins with a high occurrence of disordered regions. We also identified the core cellular process subnetworks that are targeted by all the viruses. Integration with functional RNA interference (RNAi) datasets showed that a large proportion of the targets are required for viral replication. Furthermore, we performed an interactome-informed drug re-purposing screen and identified novel activities for broad-spectrum antiviral agents against hepatitis C virus and human metapneumovirus. Altogether, these orthogonal datasets could serve as a platform for hypothesis generation and follow-up studies to broaden our understanding of the viral evasion landscape.

Subject headings

NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)

Keyword

virus-host interaction
protein-protein interaction
gene-drug interaction
innate immunity
viral evasion
network analysis
molecular innate immunity

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view