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- Merdasa, Aboma, et al.
(författare)
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Staining-free malaria diagnostics by multispectral and multimodality light-emitting-diode microscopy.
- 2013
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Ingår i: Journal of Biomedical Optics. - 1083-3668. ; 18:3
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Tidskriftsartikel (refereegranskat)abstract
- We report an accurate optical differentiation technique between healthy and malaria-infected erythrocytes by quasi-simultaneous measurements of transmittance, reflectance, and scattering properties of unstained blood smears using a multispectral and multimode light-emitting diode microscope. We propose a technique for automated imaging, identification, and counting of malaria-infected erythrocytes for real-time and cost-effective parasitaemia diagnosis as an effective alternative to the manual screening of stained blood smears, now considered to be the gold standard in malaria diagnosis. We evaluate the performance of our algorithm against manual estimations of an expert and show a spectrally resolved increased scattering from malaria-infected blood cells.
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- Wånggren, Kjell, 1954-, et al.
(författare)
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Attitudes towards embryo donation among infertile couples with frozen embryos
- 2013
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Ingår i: Human Reproduction. - : Oxford University Press (OUP). - 0268-1161 .- 1460-2350. ; 28:9, s. 2432-2439
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Tidskriftsartikel (refereegranskat)abstract
- STUDY QUESTIONWhat are the attitudes towards different aspects of embryo donation among Swedish infertile couples who have surplus cryopreserved embryos?SUMMARY ANSWERNearly three-quarters of infertile couples with surplus embryos were in favour of embryo donation. A majority of respondents were also in favour of embryos being donated for research.WHAT IS KNOWN ALREADYCurrently, embryo donation to other infertile couples is prohibited by law in Sweden. Encouraging results have been published from countries allowing embryo donation, although it is a complex procedure associated with many emotional, ethical, legal and psychosocial aspects.STUDY DESIGN, SIZE, DURATIONThis cross-sectional study included 471 infertile couples (942 patients) treated during the period March 2006 to March 2009.PARTICIPANTS/MATERIALS, SETTING, METHODSInfertile couples who had been treated at a Swedish university-based hospital and private IVF clinic and who had cryopreserved embryos were sent questionnaires with questions regarding socio-demographic data and their attitudes towards embryo donation.MAIN RESULTS AND THE ROLE OF CHANCEThe response rate to the questionnaire was 58%. Of the respondents, 76% supported the donation of surplus embryos to other infertile couples, but there were divided opinions regarding the disclosure of the genetic parents' identities. Close to 60% of the participants indicated that donations of embryos should be allowed for research and about 45% of the participants approved donations of embryos to single women.LIMITATIONS, REASONS FOR CAUTIONThe relatively low response rate and the hypothetical nature of the questions may limit the validity of the results.WIDER IMPLICATIONS OF THE FINDINGSThe results from the study indicate that cryopreserved embryos may be available for donation to other infertile couples, particularly where restrictions can be set on recipient characteristics.
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