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- Shu, Huan, et al.
(författare)
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Description of 1st trimester urinary levels of phthalate and phenol metabolites in 2,356 Swedish women in the SELMA study
- 2013
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Ingår i: Journal of Environmental Health Perspectives. - : National Institute of Environmental Health Science. - 0091-6765 .- 1552-9924. ; 121:S1
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- BACKGROUND: Epidemiological studies have found the general population has been exposed to endocrine disrupting chemicals (EDCs) such as phthalates and phenols on a regular basis. Exposures to the developing fetus during critical points in the development are a concern. In the SELMA study we investigate the importance of pre and post natal exposure for EDCs and life style factors for development of chronic diseases in offspring such as asthma and allergy, reproductive related effects, neurodevelopmental disorders and metabolic effects including overweigh and obesity among small children in Sweden. OBJECTIVES: To evaluate the extent of exposure to phthalates and phenols in the urine of 2,356 SELMA pregnant women. METHODS: One spot urine sample was taken during the 1st trimester (wk 10) from 2,356 pregnant (mean age=30), the first visit at the midwifery clinic in Sweden. The samples were analyzed for 10 phthalate metabolites from six different phthalates, bisphenol A and triclosan. Urine was added with isotopically labeled internal standards, digested by glucoronidase and then analyzed by liquid chromatography tandem mass spectrometry without any further purification. The limits of detection (LODs) were between 0.01 and 0.1ng/ml and the coefficients of variation of the quality control samples generally better than 10%. RESULTS: All samples were above the LOD. The geometric mean and range of urinary concentration (ng/ml) was: MEP (68.39; [1.30-4419.35]), MBP (69.42; [3.03-2718.94]), MBzP (16.85; [0.25-3544.51]), MEHP (3.85; [0.14-213.09]), 5-oh (16.59; [0.24-1012.98]), 5-oxo (11.26; [0.05-611.77]), 5-cx (16.07; [0.73-757.17]), 7-oh (6.42; [0.06-1726.48]), 7-oxo (GM=2.98; [0.05-635.49]), 7-cx (10.03; [0.33-1661.24]), BPA (1.54; [0.05-111.26]), and Triclosan (1.25; [0.00-3356.79]). CONCLUSIONS: Exposure of phthalates and phenols are prevalent in Swedish pregnant women (highly susceptible population). Sources of exposure, uptake routes and health effects in children that associated with prenatal exposures will be investigated in the SELMA study.
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| 3. |
- Svensson, Bo, 1957
(författare)
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Beskattning av handelsbolag
- 2013
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Ingår i: Skattenytt. - 0346-1254. ; 63:6, s. 336-337
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Svensson, Bo, 1957
(författare)
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Skatterättslig etik
- 2011
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Ingår i: Skattenytt. ; , s. 482-496
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Svensson, Bo, 1957
(författare)
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Upplösning av negativ goodwill
- 2011
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Ingår i: Skattenytt. ; , s. 201-207
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Svensson, Per-Arne, 1969, et al.
(författare)
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Alcohol consumption and alcohol problems after bariatric surgery in the swedish obese subjects study
- 2013
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Ingår i: Obesity. - : Wiley-Blackwell. - 1930-7381 .- 1930-739X. ; 21:12, s. 2444-2451
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Tidskriftsartikel (refereegranskat)abstract
- Objective Increased sensitivity to alcohol after gastric bypass has been described. The aim of this study was to investigate whether bariatric surgery is associated with alcohol problems. Design and Methods The prospective, controlled Swedish Obese Subjects (SOS) study enrolled 2,010 obese patients who underwent bariatric surgery (68% vertical banded gastroplasty (VBG), 19% banding, and 13% gastric bypass) and 2,037 matched controls. Patients were recruited between 1987 and 2001. Data on alcohol abuse diagnoses, self-reported alcohol consumption, and alcohol problems were obtained from the National Patient Register and questionnaires. Follow-up time was 8-22 years. Results During follow-up, 93.1% of the surgery patients and 96.0% of the controls reported alcohol consumption classified as low risk by the World Health Organization (WHO). However, compared to controls, the gastric bypass group had increased risk of alcohol abuse diagnoses (adjusted hazard ratio [adjHR] = 4.97), alcohol consumption at least at the WHO medium risk level (adjHR = 2.69), and alcohol problems (adjHR = 5.91). VBG increased the risk of these conditions with adjHRs of 2.23, 1.52, and 2.30, respectively, while banding was not different from controls. Conclusions Alcohol consumption, alcohol problems, and alcohol abuse are increased after gastric bypass and VBG.
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