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Intraoperative panc...
Intraoperative pancreatoscopy can improve the detection of skip lesions during surgery for intraductal papillary mucinous neoplasia : a pilot study
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- Arnelo, Urban (författare)
- Umeå universitet,Kirurgi,Division of Surgery, Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden
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- Valente, Roberto (författare)
- Umeå universitet,Kirurgi,Division of Surgery, Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden; Division of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA
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- Scandavini, Chiara Maria (författare)
- Umeå universitet,Kirurgi
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- Halimi, Asif (författare)
- Umeå universitet,Kirurgi,Division of Surgery, Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden
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- Mucelli, Raffaella M.Pozzi (författare)
- Karolinska Institutet
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- Rangelova, Elena (författare)
- Division of Surgery, Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden; Section for Upper Abdominal Surgery at Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Svensson, Johan, 1978- (författare)
- Umeå universitet,Statistik,Kirurgi
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- Schulick, Richard D. (författare)
- Division of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, CO, Aurora, United States
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- Torphy, Robert J. (författare)
- Division of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, CO, Aurora, United States
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- Fagerström, Niklas (författare)
- Department of Upper GI Diseases, Karolinska University Hospital, Stockholm, Sweden
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- Moro, Carlos Fernández (författare)
- Karolinska Institutet
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- Vujasinovic, Miroslav (författare)
- Karolinska Institutet
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- Matthias Löhr, Johannes (författare)
- Karolinska Institutet
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- Del Chiaro, Marco (författare)
- Division of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, CO, Aurora, United States
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Pancreatology (Print). - : Elsevier. - 1424-3903 .- 1424-3911. ; 23:6, s. 704-711
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives: Intraoperative pancreatoscopy is a promising procedure that might guide surgical resection for suspected main duct (MD) and mixed type (MT) intraductal papillary mucinous neoplasms (IPMNs). The aim of the present study was to assess the diagnostic yield and clinical impact of intraoperative pancreatoscopy in patients operated on for MD and MT-IPMNs.Methods: This is a retrospective cohort study. Patients undergoing surgery for suspected MD or MT-IPMN underwent intraoperative pancreatoscopy and frozen section analysis. In all patients who required extended resection due to pancreatoscopic findings, we compared the final histology with the results of the intraoperative frozen section analysis.Results: In total, 46 patients, 48% females, mean age (range) 67 years (45–82 years) underwent intraoperative pancreatoscopy. No mortality or procedure related complications were observed. Pancreatoscopy changed the operative course in 30 patients (65%), leading to extended resections in 20 patients (43%) and to parenchyma sparing procedures in 10 patients (22%). Analyzing the group of patients who underwent extended resections, 7 (35%) displayed lesions that needed further surgical treatment (six high grade dysplasia and one with G1 pancreatic neuroendocrine tumor) and among those 7, just 1 (14%) would have been detected exclusively with histological frozen section analysis of the transection margin. The combination of both pancreatoscopy and frozen section analysis lead to 86% sensitivity and 92% specificity for the detection of pathological tissue in the remnant pancreas.Conclusion: Intraoperative pancreatoscopy is a safe and feasible procedure and might allow the detection of skip lesions during surgery for suspect MD-involving IPMNs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Accuracy
- Complication
- Intra-operative pancreatoscopy
- Intraductal papillary mucinous neoplasia
- Pancreatic surgery
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Arnelo, Urban
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Valente, Roberto
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Scandavini, Chia ...
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Halimi, Asif
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Mucelli, Raffael ...
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Rangelova, Elena
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Svensson, Johan, ...
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Schulick, Richar ...
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Torphy, Robert J ...
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Fagerström, Nikl ...
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Moro, Carlos Fer ...
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Vujasinovic, Mir ...
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Matthias Löhr, J ...
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Del Chiaro, Marc ...
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