| 1. |
- Fröberg, Linus, et al.
(författare)
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Vertical InAs nanowire wrap-gate FETs
- 2006
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Ingår i: Book of abstracts: Semicond Nanowires Symp, Eindhoven, The Netherlands (2006).
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Konferensbidrag (refereegranskat)
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| 2. |
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| 3. |
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| 4. |
- Lindgren, Per, et al.
(författare)
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Time for Timber
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Embedded systems are often operating under hard real-time constraints, while at the same time being constrained by severe restrictions on power consumption. For such systems, robustness and reliability can be a question of life and death, which calls for rigorous system design and methodologies for validation. In this paper we advocate a design methodology for low-power, real-time systems, based on Timber; a pure reactive system model that allows for formal reasoning about various system properties. We outline how system specifications in Timber can be "compiled" into efficient standalone executables for general light- weight microcontroller based target platforms. Methods for resource analysis and implications to system dimensioning and validation are further discussed.
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| 5. |
- Rung, Emilia, 1974, et al.
(författare)
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Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro
- 2005
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Ingår i: Biology of reproduction. - : Oxford University Press (OUP). - 0006-3363 .- 1529-7268. ; 72:3, s. 538-45
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Tidskriftsartikel (refereegranskat)abstract
- Progesterone-receptor (PR) stimulation promotes survival in rat and human periovulatory granulosa cells. To investigate the mechanisms involved, periovulatory rat granulosa cells were incubated in vitro with or without the PR-antagonist Org 31710. Org 31710 caused the expected increase in apoptosis, and expression profiling using cDNA microarray analysis revealed regulation of several groups of genes with functional and/or metabolic connections. This regulation included decreased expression of genes involved in follicular rupture, increased stress responses, decreased angiogenesis, and decreased cholesterol synthesis. A decreased cholesterol synthesis was verified in experiments with both rat and human periovulatory granulosa cells treated with the PR-antagonists Org 31710 or RU 486 by measuring incorporation of [14C]acetate into cholesterol, cholesterol ester, and progesterone. Correspondingly, specific inhibition of cholesterol synthesis in periovulatory rat granulosa cells using 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (lovastatin, mevastatin, or simvastatin) increased apoptosis, measured as DNA fragmentation and caspase-3/7 activity. The increase in apoptosis caused by simvastatin was reversed by addition of the cholesterol synthesis-intermediary mevalonic acid. These results show that PR antagonists reduce cholesterol synthesis in periovulatory granulosa cells and that cholesterol synthesis is important for granulosa cell survival.
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| 6. |
- Svensson, Johan, 1964, et al.
(författare)
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Liver-derived IGF1 enhances the androgenic response in prostate.
- 2008
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Ingår i: The Journal of endocrinology. - 1479-6805. ; 199:3, s. 489-97
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Tidskriftsartikel (refereegranskat)abstract
- Both IGF1 and androgens are major enhancers of prostate growth and are implicated in the development of prostate hyperplasia and cancer. The aim of the present study was to investigate whether liver-derived endocrine IGF1 modulates the androgenic response in prostate. Mice with adult, liver-specific inactivation of IGF1 (LI-IGF1(-/-) mice) displayed an approximately 80% reduction in serum IGF1 levels associated with decreased prostate weight compared with control mice (anterior prostate lobe -19%, P<0.05; dorsolateral prostate (DLP) lobe -35%, P<0.01; ventral prostate (VP) lobe -47%, P<0.01). Reduced androgen receptor (Ar) mRNA and protein levels were observed in the VP lobe (-34% and -30% respectively, both P<0.05 versus control mice). Analysis of prostate morphology showed reductions in both the glandular and fibromuscular compartments of the VP and DLP lobes that were proportional to the reductions in the weights of these lobes. Immunohistochemistry revealed reduced intracellular AR immunoreactivity in the VP and DLP lobes. The non-aromatizable androgen dihydrotestosterone increased VP weight to a lesser extent in orchidectomized (ORX) LI-IGF1(-/-) mice than in ORX controls (-40%, P<0.05 versus control mice). In conclusion, deficiency of liver-derived IGF1 reduces both the glandular and fibromuscular compartments of the prostate, decreases AR expression in prostate, and reduces the stimulatory effect of androgens on VP weight. These findings may explain, at least in part, the well-known clinical association between serum IGF1 levels and conditions with abnormal prostate growth.
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| 7. |
- Svensson, Mikael, et al.
(författare)
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Musselinventering i några skånska vattendrag 2005 : med särskild fokus på tjockskalig målarmussla (Unio crassus)
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- SammanfattningSommaren 2005 genomfördes en musselinventering i Skåne. Målsättningen var att undersökaförekomsten av tjockskalig målarmusslaUnio crassus. Inventeringen gjordes riktat mot vattendragdär man visste, eller på goda grunder kunde misstänka, att arten förekommer.Tjockskalig målarmussla hittades i Mjöån (skal), Almaån, Tommarpsån, Örupsån (skal), Fyleån(skal), Björkaån, Bråån, Rössjöholmsån och Kägleån (skal). Inventeringen visade att arten förekommerbetydligt mera spritt i Skåne än vad som tidigare varit känt. I Almaån, Tommarpsånoch Bråån är bestånden goda, medan antalet levande musslor i de övriga inventerade vattendragenär litet. I flera av vattendragen hittades endast skal eller skalfragment.Den enda undersökta lokalen i Björkaån visade på goda yttre förhållanden och förekomst av levandetjockskalig målarmussla. Björkaån med biflöden är ett mycket spännande vattendrag somhar goda förutsättningar att hysa ett livskraftigt bestånd. Huruvida så är fallet får framtida inventeringarutvisa.Tecken på föryngring hittades i Almaån, Tommarpsån och Bråån.Inventeringen visar att flera av bestånden är små och hårt trängda. För att arten långsiktigt skallkunna överleva i Skåne krävs riktade bevarandeåtgärder. Sådana åtgärder kan förhoppningsvis blirealiserade inom ramen för det åtgärdsprogram som är under framtagande. Den utförda inventeringenkan förhoppningsvis vara ett bra underlag för det framtida bevarandearbetet.
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| 8. |
- Tagesson, Torbjörn, 1969-, et al.
(författare)
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Does auditor rotation influence audit quality : the contested hypotheses tested on Swedish data
- 2006
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Auditor independence is considered a key factor when ensuring high audit quality. Advocates for auditor rotation argue that rotation improves audit quality due to its positive influence on auditor independence. Opponents argue that rotation does not lead to improved audit quality, since the independence is gained at the expense of the auditors’ knowledge of business structure and routines. The aim of our study is to investigate the relationship between rotation and audit quality. We use agency theory to derive the advocate view and stewardship theory to derive the opponents’ hypothesis. These hypotheses were tested on Swedish data. The results indicate only weak support for the hypothesis that rotation influence audit quality. The weakness is partly due to measurement problems. The proxies used in the literature appear to measure different facets of audit quality. Through an interpretation of a factor analysis, we suggest two main facets, perceived audit quality, which is significantly influenced by auditor rotation, and actual audit quality, which is not influenced by rotation.
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| 9. |
- Tagesson, Torbjörn, et al.
(författare)
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Does auditor rotation influence audit quality : the contested hypotheses tested on Swedish data
- 2006
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Auditor independence is considered a key factor when ensuring high audit quality. Advocates for auditor rotation argue that rotation improves audit quality due to its positive influence on auditor independence. Opponents argue that rotation does not lead to improved audit quality, since the independence is gained at the expense of the auditors’ knowledge of business structure and routines. The aim of our study is to investigate the relationship between rotation and audit quality. We use agency theory to derive the advocate view and stewardship theory to derive the opponents’ hypothesis. These hypotheses were tested on Swedish data. The results indicate only weak support for the hypothesis that rotation influence audit quality. The weakness is partly due to measurement problems. The proxies used in the literature appear to measure different facets of audit quality. Through an interpretation of a factor analysis, we suggest two main facets, perceived audit quality, which is significantly influenced by auditor rotation, and actual audit quality, which is not influenced by rotation.
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