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| 2. |
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| 3. |
- Beckman, Viveca, et al.
(författare)
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Att socialiseras in i vuxenlivet
- 2004
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Ingår i: Holmqvist, Mona (red.). En främmande värld. - Lund : Studentlitteratur. - 9144034458 ; , s. 170-188
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Beckman, Viveca, et al.
(författare)
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Att socialiseras in i vuxenlivet
- 2004
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Ingår i: Holmqvist, Mona (red.). En främmande värld. - Lund : Studentlitteratur. ; , s. 170-188
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Gunnarsson, David, et al.
(författare)
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Pronounced induction of testicular PGF(2 alpha) and suppression of testosterone by cadmium-prevention by zinc.
- 2004
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Ingår i: Toxicology. - : Elsevier BV. - 0300-483X .- 1879-3185. ; 200:1, s. 49-58
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Tidskriftsartikel (refereegranskat)abstract
- In order to investigate the effects of cadmium (Cd) on testicular prostaglandin F(2 alpha) (PGF(2 alpha)) production, adult male Sprague-Dawley rats were exposed to CdCl(2) by subcutaneous injections. Dose-response as well as temporal-response experiments were performed, and PGF(2 alpha) levels were determined by radioimmunoassay (RIA). The highest cadmium dose (10 micromol/kg) caused a dramatic elevation of testicular PGF(2 alpha), which was established to occur 48 h after exposure. At this point of time, cadmium-treated animals displayed PGF(2 alpha) levels 16.7 times higher than saline-injected controls. No significant differences were found with the lower doses used (1 and 5 micromol/kg). In addition, the influence of pre-treatment with zinc (Zn) was assessed. The very strong stimulatory effect on PGF(2 alpha) synthesis (22.3-fold) detected after exposure to 20 micromol/kg cadmium, was completely absent in the group given zinc (1 mmol/kg) prior to cadmium exposure. Plasma testosterone concentrations were determined in the three experiments, and all groups with strongly elevated PGF(2 alpha) levels showed drastically lowered concentrations of testosterone. Zinc pre-treatment abolished not only the cadmium-induced rise in PGF(2 alpha) but also the testosterone reduction. Additionally, cadmium was found to inhibit the expression of steroidogenic acute regulatory protein (StAR), which is responsible for the rate-limiting step in steroidogenesis. The present findings establish that cadmium can cause a strong induction of testicular PGF(2 alpha) production, which might help to explain the well-known antisteroidogenic effect of this heavy metal. Such an inhibitory effect could be due to reduced levels of StAR.
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| 6. |
- Lagerkvist, Birgitta Json, et al.
(författare)
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Pulmonary epithelial integrity in children: relationship to ambient ozone exposure and swimming pool attendance.
- 2004
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Ingår i: Environmental health perspectives. - 0091-6765. ; 112:17, s. 1768-71
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Tidskriftsartikel (refereegranskat)abstract
- Airway irritants such as ozone are known to impair lung function and induce airway inflammation. Clara cell protein (CC16) is a small anti-inflammatory protein secreted by the nonciliated bronchiolar Clara cells. CC16 in serum has been proposed as a noninvasive and sensitive marker of lung epithelial injury. In this study, we used lung function and serum CC16 concentration to examine the pulmonary responses to ambient O3 exposure and swimming pool attendance. The measurements were made on 57 children 10-11 years of age before and after outdoor exercise for 2 hr. Individual O3 exposure was estimated as the total exposure dose between 0700 hr until the second blood sample was obtained (mean O3 concentration/m3 times symbol hours). The maximal 1-hr value was 118 microg/m3 (59 ppb), and the individual exposure dose ranged between 352 and 914 microg/m3hr. These O3 levels did not cause any significant changes in mean serum CC16 concentrations before or after outdoor exercise, nor was any decrease in lung function detected. However, children who regularly visited chlorinated indoor swimming pools had significantly lower CC16 levels in serum than did nonswimming children both before and after exercise (respectively, 57 +/- 2.4 and 53 +/- 1.7 microg/L vs. 8.2 +/- 2.8 and 8.0 +/- 2.6 microg/L; p < 0.002). These results indicate that repeated exposure to chlorination by-products in the air of indoor swimming pools has adverse effects on the Clara cell function in children. A possible relation between such damage to Clara cells and pulmonary morbidity (e.g., asthma) should be further investigated.
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| 7. |
- Linnarsson, MK, et al.
(författare)
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Incorporation of hydrogen (1H and 2H) into 4H-SiC during epitaxial growth
- 2002
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Ingår i: Materials Science Forum, Vols. 389-393. ; , s. 565-568
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Konferensbidrag (refereegranskat)abstract
- The hydrogen depth distribution in 4H-SiC after epitaxial growth at 1600 degreesC has been studied in detail with secondary ion mass spectrometry. Both H-1 and H-2 have been employed as carrier gas to trace the origin of the incorporated hydrogen. In particular the substrate as a prospective hydrogen source has been considered. After growth H-2 is detected throughout the whole substrate (similar to400 mum) and a considerable quantity remains after annealing at 1500 degreesC for 15 minutes.
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| 8. |
- Svensson, Sophie, 1970, et al.
(författare)
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Determination of hydrogen peroxide in exhaled breath condensate by flow injection analysis with fluorescence detection
- 2004
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Ingår i: J Chromatogr B Analyt Technol Biomed Life Sci. ; 809:2
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Tidskriftsartikel (refereegranskat)abstract
- A method for the determination of hydrogen peroxide in exhaled breath condensate (EBC) by automated flow injection analysis (FIA) with fluorescence detection was developed and validated. In the enzymatic assay a fluorescent dimer of para-hydroxyphenyl acetic acid (HPAA) was formed by the redox coupling reaction between hydrogen peroxide and horseradish peroxidase (HRP). The calibration curve of hydrogen peroxide was linear over a range of 40-5000nM. The coefficient of variation (CV) for within-day precision was 1-3%; for between-day precision, it was 2-5% over the validated range. The assay requires a small sample aliquot (150microl) and no incubation time, and has an analytical runtime of <2min. It is therefore suitable for larger studies. The method was used to detect hydrogen peroxide in EBC of asthmatic patients and healthy volunteers. A statistically significant difference was found between patients with asthma (n = 19) and control subjects without asthma (n = 19), 780nM versus 480nM (P = 0.03).
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| 9. |
- Unéus, Lars, et al.
(författare)
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The effect of hydrogen diffusion in p- and n-type SiC Schottky diodes at high temperatures
- 2002
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Ingår i: Materials Science Forum, Vols. 389-393. ; , s. 1419-1422, s. 1419-1422
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Konferensbidrag (refereegranskat)abstract
- We present here the effect of a hydrogen anneal at 600degreesC for Schottky sensor devices based on n- and p-type 4H SiC. The devices have gate contacts of Ta/Pt, or TaSix/Pt. The catalytic metal gate dissociates hydrogen and thus promotes diffusion of hydrogen atoms into the SiC, where the atoms will trap or react with different impurities, defects or surface states. This will change parameters such as the carrier concentrations, the defect density of the material or the surface resistivity at the SiC/SiO2 interface. The current-voltage and the capacitance-voltage characteristics were measured before and after annealing in hydrogen and oxygen containing atmosphere, and the results show a reversible effect in the I-V characteristics.
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