| 1. |
- Svensson, Elin M., 1985-, et al.
(författare)
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The Potential for Treatment Shortening With Higher Rifampicin Doses : Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis
- 2018
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Ingår i: Clinical Infectious Diseases. - : OXFORD UNIV PRESS INC. - 1058-4838 .- 1537-6591. ; 67:1, s. 34-41
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Tidskriftsartikel (refereegranskat)abstract
- Background. Tuberculosis remains a huge public health problem and the prolonged treatment duration obstructs effective tuberculosis control. Higher rifampicin doses have been associated with better bactericidal activity, but optimal dosing is uncertain. This analysis aimed to characterize the relationship between rifampicin plasma exposure and treatment response over 6 months in a recent study investigating the potential for treatment shortening with high-dose rifampicin. Methods. Data were analyzed from 336 patients with pulmonary tuberculosis (97 with pharmacokinetic data) treated with rifampicin doses of 10, 20, or 35 mg/kg. The response measure was time to stable sputum culture conversion (TSCC). We derived individual exposure metrics with a previously developed population pharmacokinetic model of rifampicin. TSCC was modeled using a parametric time-to-event approach, and a sequential exposure-response analysis was performed. Results. Higher rifampicin exposures increased the probability of early culture conversion. No maximal limit of the effect was detected within the observed range. The expected proportion of patients with stable culture conversion on liquid medium at week 8 was predicted to increase from 39% (95% confidence interval, 37%-41%) to 55% (49%-61%), with the rifampicin area under the curve increasing from 20 to 175 mg/L.h (representative for 10 and 35 mg/kg, respectively). Other predictors of TSCC were baseline bacterial load, proportion of culture results unavailable, and substitution of ethambutol for either moxifloxacin or SQ109. Conclusions. Increasing rifampicin exposure shortened TSCC, and the effect did not plateau, indicating that doses >35 mg/kg could be yet more effective. Optimizing rifampicin dosage while preventing toxicity is a clinical priority.
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| 2. |
- Svensson, Jacob, 1978-
(författare)
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Boundary Layer Parametrization in Numerical Weather Prediction Models
- 2015
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Numerical weather prediction (NWP) and climate models have shown to have a challenge to correctly simulate stable boundary layers and diurnal cycles. This aim of this study is to evaluate, describe and give suggestions for improvements of the descriptions of stable boundary layers in operational NWP models. Two papers are included. Paper I focuses on the description of the surface and the interactions between the surface and the boundary layer in COAMPSR, a regional NWP model. The soil parametrization showed to be of great importance to the structure of the boundary layer. Moreover, it showed also that a low frequency of radiation calculations caused a bias in received solar energy at the surface.In paper II, the focus is on the formulation of the turbulent transport in stable boundary layers. There, an implementation of a diffusion parametrization based on the amount of turbulent kinetic energy (TKE) is tested in a single column model (SCM) version of the global NWP model Integrated Forecast System (IFS). The TKE parametrization turned out to behave similarly as the currently operational diffusion parametrization in convective regimes and neutral regimes, but showed to be less diffusive in weakly stable and stable conditions. The formulations of diffusion also turned out to be very dependent on the length scale formulation. If the turbulence and the gradients of wind temperature and wind are weak, the magnitude of turbulence can enter an oscillating mode. This oscillation can be avoided with the use of a lower limit of the length scale.
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| 3. |
- Andersson, Martin, 1988-
(författare)
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Migration i 1600-talets Sverige : Älvsborgs lösen 1613–1618
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis is a study of migration in the early seventeenth-century Swedish feudal society, and of its migration regime; that is the political, legal and economic structures that shaped the migration patterns. The most important sources are taxation records from Älvsborgs lösen, containing demographic migration data for large parts of the Swedish realm 1613–1618. The migration regime is also studied through sources such as legislation and legal records.Migration rates and migration distances are analysed for households and for servants. Although most migration was short-distance, different social groups had different migration patterns. Further, urban migration patterns, inter-regional and international migration are analysed. Concerning migration rates, the study shows that migration was as common in seventeenth-century Sweden as in other parts of Europe (including England), and also as common as in the nineteenth century. In the thesis, legislation and legal practices concerning the mobility of tenants and servants, as well as concerning urban migration, international migration and forced migration (banishments and deportations) are studied. The study of the migration regime found that since not only rural but ideally also urban production was geographically fixed, regulating migration and population mobility was an important issue within the Swedish feudal society. The results confirm the fundamental importance of migration for the Swedish seventeenth-century feudal society, in which labour was free while the means of production were immobile. Through comparisons with historical research on other regions, this result is evidently not only valid for seventeenth-century Sweden, but may be generalized also for other feudal societies.
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| 4. |
- Bartesaghi, Stefano, et al.
(författare)
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Thermogenic Activity of UCP1 in Human White Fat-Derived Beige Adipocytes.
- 2015
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Ingår i: Molecular endocrinology (Baltimore, Md.). - : The Endocrine Society. - 1944-9917 .- 0888-8809. ; 29, s. 130-139
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Tidskriftsartikel (refereegranskat)abstract
- Heat-producing beige/brite (brown-in-white) adipocytes in white adipose tissue have the potential to suppress metabolic disease in mice and hold great promise for the treatment of obesity and type 2 diabetes in humans. Here, we demonstrate that human adipose-derived stromal/progenitor cells (hASCs) from sc white adipose tissue can be efficiently converted into beige adipocytes. Upon pharmacological activation of PPARγ, hASC-derived adipocytes activated beige fat-selective genes and a brown/beige fat-selective electron transport chain gene program. Importantly, hASC-derived beige fat cells displayed the bioenergetic characteristics of genuine brown fat cells, including a capacity for increased respiratory uncoupling in response to β-adrenergic agonists. Furthermore, knock-down experiments reveal that the thermogenic capacity of human beige fat cells was entirely dependent on the presence of uncoupling protein 1. In summary, this study reveals that hASCs can be readily differentiated into beige adipocytes that, upon activation, undergo uncoupling protein 1-dependent thermogenesis.
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| 5. |
- Bengtsson, Erik, et al.
(författare)
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Aristocratic Wealth and Inequality in a Changing Society: Sweden, 1750–1900
- 2019
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Ingår i: Scandinavian Journal of History. - : Informa UK Limited. - 1502-7716 .- 0346-8755. ; 44:1, s. 27-52
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Tidskriftsartikel (refereegranskat)abstract
- The role of the European nobility and their ability to retain their political and economic power are part of the debate on the modernization of Europe’s economy. This paper contributes to the literature by exploring the wealth of the Swedish nobility as the country evolved from an agrarian to an industrial economy. We use a sample of 200+ probate inventories of nobles for each of the benchmark years 1750, 1800, 1850 and 1900. We show that the nobility, less than 0.5 per cent of the population, was markedly dominant in 1750: the average noble was 60 times richer than the average person, and the nobles held 29 per cent of all private wealth. 90 per cent of the nobles were richer than the average person. By 1900 the advantage of the nobles’ wealth had declined; the group held only 5 per cent of total private wealth. At the same time, stratification within the nobility had increased dramatically. One group of super-rich Swedish nobles, often large land owners from the high nobility, possessed the biggest fortunes, but a large minority of nobles were no richer than the average Swede.
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| 6. |
- Bengtsson, Erik, et al.
(författare)
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ARISTOCRATIC WEALTH AND INEQUALITY IN A CHANGING SOCIETY: SWEDEN, 1750–1900
- 2019
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Ingår i: Scandinavian Journal of History. - : Routledge. - 0346-8755. ; 44:1, s. 27-52
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Tidskriftsartikel (refereegranskat)abstract
- The role of the European nobility and their ability to retain their political and economic power are part of the debate on the modernization of Europe’s economy. This paper contributes to the literature by exploring the wealth of the Swedish nobility as the country evolved from an agrarian to an industrial economy. We use a sample of 200+ probate inventories of nobles for each of the benchmark years 1750, 1800, 1850 and 1900. We show that the nobility, less than 0.5 per cent of the population, was markedly dominant in 1750: the average noble was 60 times richer than the average person, and the nobles held 29 per cent of all private wealth. 90 per cent of the nobles were richer than the average person. By 1900 the advantage of the nobles’ wealth had declined; the group held only 5 per cent of total private wealth. At the same time, stratification within the nobility had increased dramatically. One group of super-rich Swedish nobles, often large land owners from the high nobility, possessed the biggest fortunes, but a large minority of nobles were no richer than the average Swede.
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| 7. |
- Bengtsson, Erik, et al.
(författare)
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Mercantilist Inequality : Wealth and Poverty in Stockholm 1650-1750
- 2019
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This paper maps social structure, poverty, wealth and economic inequality in Stockholm from 1650 to 1750. We begin by establishing the social structure, using census data and other sources. To study wealth and poverty, the main sources are a sample from the wealth tax of 1715, and probate inventory samples from 1650, 1700 and 1750. These provide detailed and sometimes surprising insights into the living standards of both the poor and rich. Stockholm in this period was a starkly unequal city, with the top decile of wealth holders owning about 90 per cent of total wealth. We argue that this inequality was the result of deliberate policy – the Mercantilist conviction of “just rewards” for each and every one according to his or her standing. The case of Stockholm shows the need for the historical inequality literature to consider class and power relations to understand the determinants of inequality.
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| 8. |
- Bengtsson, Erik, et al.
(författare)
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The Wealth of the Richest : Inequality and the Nobility in Sweden, 1750–1900
- 2017
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The role of the European nobility and their ability to retain their political and economic power are part of the debate on the modernization of the European economy. This paper contributes to the literature by exploring the wealth of the Swedish nobility as Sweden evolved from an agrarian to an industrial economy. We use a sample of 200+ probate inventories of nobles for each of the benchmark years 1750, 1800, 1850 and 1900. Medieval and early modern Sweden often has been described as not fully feudal. In line with this, and the (perceived) comparative strength of the peasantry, the nobility is assumed to have been comparatively unimportant and less economically dominant than elsewhere in Europe. We show that the nobility, less than 0.5 per cent of the population, was very dominant in 1750: the average noble was 60 times richer than the average person, and the nobles held 29 per cent of private wealth while 90 per cent of the nobles were richer than the average person. In 1900 the nobles’ advantage had decreased but the stratification within the nobility had increased dramatically. There was a group of super-rich nobles, often large land owners from the high nobility, who possessed the biggest fortunes in Sweden. But there was also a large minority who were not richer than the average Swede. The overall wealth advantage of the nobles, however, hints at that while not all nobles were economically upper class in 1900, most of the upper class were nobles.
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| 9. |
- Bengtsson, Erik, et al.
(författare)
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The wealth of the Swedish peasant farmer class 1750–1900 : Composition and distribution
- 2018
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Using about 1,730 probate inventories, this paper studies the wealth of peasant farmers in Sweden for the years 1750, 1800, 1850 and 1900. The Gini coefficient for the farmers’ wealth grew from 0.46 in 1750 to 0.73 in 1900. Average wealth grew rapidly, tripling over the nineteenth century. Looking in greater depth at four local areas (Kullings, Sjuhundra, Lagunda, and Bara hundreds), we show that over the period the diversity of farmers’ wealth grew, as did their financial sophistication; borrowing and lending patterns became more complex and the use of banks and other institutions grew while personal financial transactions became rarer. Farmers who lived close to the major grain markets in Stockholm and the mining district Bergslagen were wealthier than others, as were farmers on fertile plains and, in 1900, those living in coastal areas. Increased market access by 1900 – in terms of cities and foreign demand – meant that farmers well-placed in terms of geography and infrastructure benefited much more than farmers on what became the periphery, as regional inequality within the farmer class increased. Over the nineteenth century land prices increased much more in some areas than in others, but in the country as a whole they rose steeply.
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| 10. |
- Bengtsson, Erik, et al.
(författare)
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Wealth inequality in Sweden 1750–1900
- 2018
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Ingår i: Economic History Review. - : Wiley. - 1468-0289 .- 0013-0117. ; 71:3, s. 772-794
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Tidskriftsartikel (refereegranskat)abstract
- This article examines the evolution of wealth inequality in Sweden from 1750 to 1900, contributing both to the debate on early modern and modern inequality and to the general debate on the pattern of inequality during industrialization. The pre‐industrial period (1750–1850) is for the first time examined for Sweden at the national level. The study uses a random sample of probate inventories from urban and rural areas across the country, adjusted for age and social class. Estimates are provided for the years 1750, 1800, 1850, and 1900. The results show a gradual growth in inequality as early as the mid‐eighteenth century, with the sharpest rise in the late nineteenth century. Whereas the early growth in inequality was connected to changes in the countryside and in agriculture, the later growth was related to industrialization encompassing both compositional effects and strong wealth accumulation among the richest. The level of inequality in Sweden in 1750 was lower than for other western European countries, but by 1900 Sweden was just as unequal.
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