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- Marton, J., et al.
(författare)
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New nepenthone and thevinone derivatives
- 1997
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Ingår i: Bioorganic & Medicinal Chemistry. - : Elsevier BV. - 0968-0896 .- 1464-3391. ; 5:2, s. 369-382
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Tidskriftsartikel (refereegranskat)abstract
- The diastereoselective reaction of thevinone (2a) and nepenthone (2c) and their dihydro derivatives (2b and d) with Grignard reagents afforded new N-substituted (20S)- and (20R)-phenyI-6,14-ethenomorphinan derivatives (6a-y). The Grignard reaction of the N-substituted-N-demethyl derivatives 4a-f and 4m-r with methylmagnesium iodide resulted in the (20R)-phenyl tertiary alcohols 5a-f and 5m-r, respectively, but the conversion of 4g-l and that of the N-substituted-dihydrothevinone derivatives with phenylmagnesium bromide afforded the (20S)-phenyl derivatives 5g-l and 5s-y, respectively. The N-cyclopropylmethyl-, N-β-phenylethyl-, and N-propyl derivatives were prepared by the 3-O-demethylation of compounds 5. For the synthesis of the N-allyl-, N-dimethylallyl-, and N-propargyl compounds 2a-d were reacted with the corresponding Grignard reagent, and treatment of the products with cyanogen bromide gave the cyanamides 8a-d. These latter compounds were transformed into 10a,b,d, whose alkylation led to the target derivatives 6d-f, j-l, p-r, and w-y. The biochemical investigation of these substances showed that the affinities to the δ-opioid receptors were high, but the selectivity was low. Tn two cases (6c and 11d) a μ-opioid receptor specificity was observed.
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| 8. |
- Csende, F., et al.
(författare)
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Preparation and antiarrhythmic activity of hexahydroisoindol-1-one derivatives
- 1999
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Ingår i: Scientia pharmaceutica. - : MDPI. - 0036-8709 .- 2218-0532. ; 67:2, s. 149-158
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Tidskriftsartikel (refereegranskat)abstract
- The synthesis of a series of partially saturated isoindol-1-one from 2- p-toluoyl-cyclohexanecarboxylic acid is described. The compounds were evaluated for their ability to protect against chloroform-induced fibrillation in mice.
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| 9. |
- G, Eneroth, et al.
(författare)
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Applying ATM/AAL2 as a switching technology in third-generation mobile access networks
- 1999
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Ingår i: IEEE Communications Magazine. - : IEEE Press. - 0163-6804 .- 1558-1896. ; 37:6, s. 112-122
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Tidskriftsartikel (refereegranskat)abstract
- In this article we focus on the transport and switching part of third-generation mobile access networks and outline some important aspects of applying ATM in these networks. In particular, we argue that in order for the mobile access network to support low-bit-rate delay-sensitive traffic consisting of short packets, the standardization of a new ATM adaptation layer, AAL2, and associated signaling protocol has been necessary. The AAL2 protocol has been designed to support low-bit-rate delay-sensitive services (typically compressed voice) where other adaptation layers fail to deliver the required QoS and maintain efficient resource utilization at the same time. Furthermore, in order to provide mobility and soft handover support in CDMA-based mobile networks such as UMTS or IMT-2000, there is also a strong demand for fast connection establishment and release. Therefore, when designing ATM-based cellular access networks some specific architectural and traffic management issues need to be addressed.
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