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- Fekete, Tünde, et al.
(författare)
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Constraints for monocyte-derived dendritic cell functions under inflammatory conditions.
- 2012
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Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 42:2, s. 458-69
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Tidskriftsartikel (refereegranskat)abstract
- The activation of TLRs expressed by macrophages or DCs, in the long run, leads to persistently impaired functionality. TLR signals activate a wide range of negative feedback mechanisms; it is not known, however, which of these can lead to long-lasting tolerance for further stimulatory signals. In addition, it is not yet understood how the functionality of monocyte-derived DCs (MoDCs) is influenced in inflamed tissues by the continuous presence of stimulatory signals during their differentiation. Here we studied the role of a wide range of DC-inhibitory mechanisms in a simple and robust model of MoDC inactivation induced by early TLR signals during differentiation. We show that the activation-induced suppressor of cytokine signaling 1 (SOCS1), IL-10, STAT3, miR146a and CD150 (SLAM) molecules possessed short-term inhibitory effects on cytokine production but did not induce persistent DC inactivation. On the contrary, the LPS-induced IRAK-1 downregulation could alone lead to persistent MoDC inactivation. Studying cellular functions in line with the activation-induced negative feedback mechanisms, we show that early activation of developing MoDCs allowed only a transient cytokine production that was followed by the downregulation of effector functions and the preservation of a tissue-resident non-migratory phenotype.
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| 2. |
- Szabo, Attila, 1965-
(författare)
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Matematiska förmågors interaktion och det matematiska minnets roll vid lösning av matematiska problem
- 2013
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The thesis deals with the interaction of mathematical abilities and the mathematical memory's role in problem-solving. To examine those phenomena, I analyzed the expression of mathematical abilities for high achieving students from upper secondary school. The study shows that the mathematical memory accounts for a relatively small proportion of time of the problem-solving process and that the mathematical memory emerges mainly during the initial phase of the process. Although the mathematical memory accounts for a small percentage of the time of the problem-solving process, the mathematical memory has a decisive role for the choice of problem-solving methods, because the students choose their solution methods in the initial phase of their problem-solving activity. The study shows that the choice of problem-solving method has significant consequences for the students' problem-solving activity; if the chosen methods did not lead to the desired outcome, so the students found it very difficult to change their initially chosen problem-solving methods. The study also shows that students who use general problem-solving methods perform better than students who use numerical methods.
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