Sökning: WFRF:(Szponar Bogumila)
> (2007) >
3-Hydroxy fatty aci...
3-Hydroxy fatty acids in faeces of patients with Crohn's disease or ulcerative colitis as a non-invasive diagnostic approach
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de la Cochetiére, Marie France (författare)
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Rougé, Carol (författare)
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Szponar, Bogumila (författare)
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- Larsson, Lennart (författare)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
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Potel, Gilles (författare)
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(creator_code:org_t)
- 2009-07-11
- 2007
- Engelska.
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Ingår i: Microbial Ecology in Health and Disease. - : Informa UK Limited. - 0891-060X .- 1651-2235. ; 19, s. 1-6
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The microbiota is part of the gastrointestinal ecosystem. A more detailed understanding should provide insight into multiple human disease states. This study investigated inflammatory bowel disease (Crohn's disease and ulcerative colitis). Previous analyses have suggested a role of gram-negative bacteria including Escherichia coli. An integrated procedure is presented where gas chromatography-mass spectrometry is used to determine chemical markers of gram-negative bacterial lipopolysaccharide (3-hydroxy fatty acids with 10-18 carbon atoms) in faecal samples. Six patients with Crohn's disease (CD), five with ulcerative colitis (UC) and six healthy adults were chosen as groups of interest. Nine saturated straight-chain 3-OH fatty acids of 10-18 carbon chain lengths and six iso- and anteiso-branched-chain 3-OH fatty acids of 15-18 carbon chain lengths were detected. Significant differences were found in the 3-OH n-C17:0, 3-OH i-C18:0 and 3-OH n-C18:0 composition of faeces. The present study therefore confirms that alteration of the composition of the endogenous gram-negative microbiota may be of importance in inflammatory bowel disease and those alterations could be detected with a non-invasive chemical-analytical approach.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- faecal microbiota
- gas chromatography-mass spectrometry
- inflammatory bowel diseases
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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