| 1. |
- Eklund, Linda M., et al.
(författare)
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Cold air exposure at -15 °C induces more airway symptoms and epithelial stress during heavy exercise than rest without aggravated airway constriction
- 2022
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Ingår i: European Journal of Applied Physiology. - : Springer. - 1439-6319 .- 1439-6327. ; 122:12, s. 2533-2544
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Exposure to cold air may harm the airways. It is unclear to what extent heavy exercise adds to the cold-induced effects on peripheral airways, airway epithelium, and systemic immunity among healthy individuals. We investigated acute effects of heavy exercise in sub-zero temperatures on the healthy airways.Methods: Twenty-nine healthy individuals underwent whole body exposures to cold air in an environmental chamber at − 15 °C for 50 min on two occasions; a 35-min exercise protocol consisting of a 5-min warm-up followed by 2 × 15 min of running at 85% of VO2max vs. 50 min at rest. Lung function was measured by impulse oscillometry (IOS) and spirometry before and immediately after exposures. CC16 in plasma and urine, and cytokines in plasma were measured before and 60 min after exposures. Symptoms were surveyed pre-, during and post-trials.Results: FEV1 decreased after rest (− 0.10 ± 0.03 L, p < 0.001) and after exercise (− 0.06 ± 0.02 L, p = 0.012), with no difference between trials. Exercise in − 15 °C induced greater increases in lung reactance (X5; p = 0.023), plasma CC16 (p < 0.001) as well as plasma IL-8 (p < 0.001), compared to rest. Exercise induced more intense symptoms from the lower airways, whereas rest gave rise to more general symptoms.Conclusion: Heavy exercise during cold air exposure at − 15 °C induced signs of an airway constriction to a similar extent as rest in the same environment. However, biochemical signs of airway epithelial stress, cytokine responses, and symptoms from the lower airways were more pronounced after the exercise trial.
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| 2. |
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| 3. |
- Gauvreau, GM, et al.
(författare)
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Allergen provocation tests in respiratory research: building on 50 years of experience
- 2022
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Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 60:2
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Tidskriftsartikel (refereegranskat)abstract
- The allergen provocation test is an established model of allergic airway diseases, including asthma and allergic rhinitis, allowing the study of allergen-induced changes in respiratory physiology and inflammatory mechanisms in sensitised individuals as well as their associations. In the upper airways, allergen challenge is focused on the clinical and pathophysiological sequelae of the early allergic response, and is applied both as a diagnostic tool and in research settings. In contrast, bronchial allergen challenge has almost exclusively served as a research tool in specialised research settings with a focus on the late asthmatic response and the underlying type 2 inflammation. The allergen-induced late asthmatic response is also characterised by prolonged airway narrowing, increased nonspecific airway hyperresponsiveness and features of airway remodelling including the small airways, and hence allows the study of several key mechanisms and features of asthma. In line with these characteristics, allergen challenge has served as a valued tool to study the cross-talk of the upper and lower airways and in proof-of-mechanism studies of drug development. In recent years, several new insights into respiratory phenotypes and endotypes including the involvement of the upper and small airways, innovative biomarker sampling methods and detection techniques, refined lung function testing as well as targeted treatment options further shaped the applicability of the allergen provocation test in precision medicine. These topics, along with descriptions of subject populations and safety, in line with the updated Global Initiative for Asthma 2021 document, will be addressed in this review.
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| 4. |
- Ji, Yilin, et al.
(författare)
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Virtual Drive Testing Over-the-Air for Vehicular Communications
- 2020
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Ingår i: IEEE Transactions on Vehicular Technology. - : Institute of Electrical and Electronics Engineers Inc.. - 0018-9545 .- 1939-9359. ; 69:2, s. 1203-1213
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Tidskriftsartikel (refereegranskat)abstract
- Multiple-input multiple-output (MIMO) over-the-air (OTA) testing is a standardized procedure to evaluate the performance of MIMO-capable devices such as mobile phones and laptops. With the growth of the vehicle-to-everything (V2X) service, the need for vehicular communication testing is expected to increase significantly. The so-called multi-probe anechoic chamber (MPAC) setup is standardized for MIMO OTA testing. Typically, a test zone of 0.85 wavelength in diameter can be achieved with an 8-probe MPAC setup, which can encompass device-under-test (DUT) of small form factors. However, a test zone of this size may not be large enough to encompass DUTs such as cars. In this article, the sufficient number of OTA probes for the MPAC setup for car testing is investigated with respect to the emulation accuracy. Our investigation shows that the effective antenna distance of the DUT is more critical than its physical dimensions to determine the required number of OTA probes. In addition, throughput measurements are performed under the standard SCME UMa and UMi channel models with the 8-probe MPAC setup and the wireless cable setup, i.e. another standardized testing setup. The results show reasonably good agreement between the two setups for MIMO OTA testing with cars under the standard channel models.
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| 5. |
- Manoj, B. R., et al.
(författare)
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MOVING OBJECT CLASSIFICATION WITH A SUB-6 GHZ MASSIVE MIMO ARRAY USING REAL DATA
- 2021
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Ingår i: 2021 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH AND SIGNAL PROCESSING (ICASSP 2021). - : IEEE. - 2379-190X .- 1520-6149. - 9781728176055 - 9781728176062 ; , s. 8133-8137
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Konferensbidrag (refereegranskat)abstract
- Classification between different activities in an indoor environment using wireless signals is an emerging technology for various applications, including intrusion detection, patient care, and smart home. Researchers have shown different methods to classify activities and their potential benefits by utilizing WiFi signals. In this paper, we analyze classification of moving objects by employing machine learning on real data from a massive multi-input-multi-output (MIMO) system in an indoor environment. We conduct measurements for different activities in both line-of-sight and non line-of-sight scenarios with a massive MIMO testbed operating at 3.7 GHz. We propose algorithms to exploit amplitude and phase-based features classification task. For the considered setup, we benchmark the classification performance and show that we can achieve up to 98% accuracy using real massive MIMO data, even with a small number of experiments. Furthermore, we demonstrate the gain in performance results with a massive MIMO system as compared with that of a limited number of antennas such as in WiFi devices.
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| 6. |
- Manoj, Banugondi Rajashekara, et al.
(författare)
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Sensing and Classification Using Massive MIMO : A Tensor Decomposition-Based Approach
- 2021
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Ingår i: IEEE Wireless Communications Letters. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 2162-2337 .- 2162-2345. ; 10:12, s. 2649-2653
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Tidskriftsartikel (refereegranskat)abstract
- Wireless-based activity sensing has gained significant attention due to its wide range of applications. We investigate radio-based multi-class classification of human activities using massive multiple-input multiple-output (MIMO) channel measurements in line-of-sight and non line-of-sight scenarios. We propose a tensor decomposition-based algorithm to extract features by exploiting the complex correlation characteristics across time, frequency, and space from channel tensors formed from the measurements, followed by a neural network that learns the relationship between the input features and output target labels. Through evaluations of real measurement data, it is demonstrated that the classification accuracy using a massive MIMO array achieves significantly better results compared to the state-of-the-art even for a smaller experimental data set.
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| 7. |
- Sellgren, C. M., et al.
(författare)
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GRK3 deficiency elicits brain immune activation and psychosis
- 2021
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 26, s. 6820-6832
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Tidskriftsartikel (refereegranskat)abstract
- The G protein-coupled receptor kinase (GRK) family member protein GRK3 has been linked to the pathophysiology of schizophrenia and bipolar disorder. Expression, as well as protein levels, of GRK3 are reduced in post-mortem prefrontal cortex of schizophrenia subjects. Here, we investigate functional behavior and neurotransmission related to immune activation and psychosis using mice lacking functional Grk3 and utilizing a variety of methods, including behavioral, biochemical, electrophysiological, molecular, and imaging methods. Compared to wildtype controls, the Grk3(-/-) mice show a number of aberrations linked to psychosis, including elevated brain levels of IL-1 beta, increased turnover of kynurenic acid (KYNA), hyper-responsiveness to D-amphetamine, elevated spontaneous firing of midbrain dopamine neurons, and disruption in prepulse inhibition. Analyzing human genetic data, we observe a link between psychotic features in bipolar disorder, decreased GRK expression, and increased concentration of CSF KYNA. Taken together, our data suggest that Grk3(-/-) mice show face and construct validity relating to the psychosis phenotype with glial activation and would be suitable for translational studies of novel immunomodulatory agents in psychotic disorders.
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| 8. |
- Stenfors, Nikolai, et al.
(författare)
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A breathing mask attenuates acute airway responses to exercise in sub-zero environment in healthy subjects
- 2022
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Ingår i: European Journal of Applied Physiology. - : Springer Science+Business Media B.V.. - 1439-6319 .- 1439-6327. ; 122, s. 1473-1484
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Cold air exposure is associated with increased respiratory morbidity and mortality. Repeated inhalation of cold and dry air is considered the cause of the high prevalence of asthma among winter endurance athletes. This study assessed whether a heat- and moisture-exchanging breathing device (HME) attenuates airway responses to high-intensity exercise in sub-zero temperatures among healthy subjects.Methods: Using a randomized cross-over design, 23 healthy trained participants performed a 30-min warm-up followed by a 4-min maximal, self-paced running time trial in − 15 °C, with and without HME. Lung function was assessed pre- and immediately post-trials. Club cell protein (CC-16), 8-isoprostane, and cytokine concentrations were measured in plasma and urine pre- and 60 min post trials. Symptoms were assessed prior to, during, and immediately after each trial in the chamber.Results: HME use attenuated the decrease in forced expiratory volume in 1 s (FEV1) post trials (∆FEV1: mean (SD) HME − 0.5 (1.9) % vs. no-HME − 2.7 (2.7) %, p = 0.002). HME also substantially attenuated the median relative increase in plasma-CC16 concentrations (with HME + 27% (interquartile range 9–38) vs no-HME + 121% (55–162), p < 0.001) and reduced airway and general symptom intensity, compared to the trial without HME. No significant changes between trials were detected in urine CC16, 8-isoprostane, or cytokine concentrations.Conclusion: The HME attenuated acute airway responses induced by moderate-to-maximal-intensity exercise in − 15 °C in healthy subjects. Further studies are needed to examine whether this HMEs could constitute primary prevention against asthma in winter endurance athletes.
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