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- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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- Stepien, M., et al.
(författare)
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Metabolic perturbations prior to hepatocellular carcinoma diagnosis: Findings from a prospective observational cohort study
- 2021
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 148:3, s. 609-625
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Tidskriftsartikel (refereegranskat)abstract
- Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose serum concentrations are associated with HCC development, using biological samples from within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (>520 000 participants), where we identified 129 HCC cases matched 1:1 to controls. We conducted high-resolution untargeted liquid chromatography-mass spectrometry-based metabolomics on serum samples collected at recruitment prior to cancer diagnosis. Multivariable conditional logistic regression was applied controlling for dietary habits, alcohol consumption, smoking, body size, hepatitis infection and liver dysfunction. Corrections for multiple comparisons were applied. Of 9206 molecular features detected, 220 discriminated HCC cases from controls. Detailed feature annotation revealed 92 metabolites associated with HCC risk, of which 14 were unambiguously identified using pure reference standards. Positive HCC-risk associations were observed forN1-acetylspermidine, isatin,p-hydroxyphenyllactic acid, tyrosine, sphingosine,l,l-cyclo(leucylprolyl), glycochenodeoxycholic acid, glycocholic acid and 7-methylguanine. Inverse risk associations were observed for retinol, dehydroepiandrosterone sulfate, glycerophosphocholine, gamma-carboxyethyl hydroxychroman and creatine. Discernible differences for these metabolites were observed between cases and controls up to 10 years prior to diagnosis. Our observations highlight the diversity of metabolic perturbations involved in HCC development and replicate previous observations (metabolism of bile acids, amino acids and phospholipids) made in Asian and Scandinavian populations. These findings emphasize the role of metabolic pathways associated with steroid metabolism and immunity and specific dietary and environmental exposures in HCC development.
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| 7. |
- Sumaila, U. Rashid, et al.
(författare)
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WTO must ban harmful fisheries subsidies
- 2021
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Noardo, F., et al.
(författare)
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INTEGRATING EXPERTISES and AMBITIONS for DATA-DRIVEN DIGITAL BUILDING PERMITS - The EUNET4DBP
- 2020. - 4/W1
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Ingår i: International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences. - 1682-1750. ; 44, s. 103-110
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Konferensbidrag (refereegranskat)abstract
- The digitalization of the process for building permit (involving the use of 3D information systems) is seen as a priority in a wide part of the world. Since it is a very multidisciplinary use case, involving a variety of stakeholders tackling complex issues and topics, some of them joined their efforts and skills in the European Network for Digital Building Permit. The initial activity of the network, after a review of on-going experiences, was a workshop to share knowledge about the topics involved and to identify the main ambitions of the network with respect to three pillars (i.e. Process - Rules and Requirements - Technology) and the related requirements. It was achieved through a collective brainstorming activity guided by digital tools, whose results were further analysed in a post-processing phase. Such results are presented in this paper and will be the base for planning the future network activity.
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| 9. |
- Urban, Edward R., et al.
(författare)
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The importance of bottom-up approaches to international cooperation in ocean science: The iron story
- 2020
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Ingår i: Oceanography. - : The Oceanography Society. - 1042-8275. ; 33, s. 11-15
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- © 2020, Oceanography Society. All rights reserved. In the past decade, several international efforts developed to address urgent societal issues have been identified through, for example, the United Nations 2030 Agenda for Sustainable Development and its associated 17 Sustainable Development Goals and the United Nations Decade of Ocean Science for Sustainable Development (2021–2030). These worthy efforts will bring ocean science research to bear on problems that need attention in the short term. Yet, there is also a continuing need at the international level to support fundamental ocean science and solve methodological issues over the long term. While knowledge needs to be created before it can be applied, national and international science strategy documents often do not mention the need to maintain the health of the basic science enterprise. We argue that international organizations designed to create knowledge must be maintained and strengthened to inform decisions on how to allocate funding for generating knowledge about the ocean versus solving ocean problems. We use the ocean iron cycle as an example of the benefits of using such a “bottom-up” approach to knowledge generation.
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