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The influence of hy...
The influence of hypoglycaemia on regional cerebral blood flow and cerebral volume in type 1 (insulin-dependent) diabetes mellitus
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Tallroth, G (författare)
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- Ryding, Erik (författare)
- Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Agardh, Carl-David (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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(creator_code:org_t)
- 1993
- 1993
- Engelska.
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Ingår i: Diabetologia. - 1432-0428. ; 36:6, s. 530-535
- Relaterad länk:
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http://dx.doi.org/10...
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Abstract
Ämnesord
Stäng
- The effect of moderate hypoglycaemia (venous blood glucose 2.0 +/- 0.2 mmol/l; mean +/- SD) on regional cerebral blood flow and cerebral volume was studied in a group of ten right-handed patients with Type 1 (insulin-dependent) diabetes mellitus (age 26.0 +/- 2.4 years, duration 18.4 +/- 3.8 years) using an intravenous Xenon 133 single photon emission computed tomography technique. After 10 min of hypoglycaemia, global cerebral blood flow had increased to 55.8 +/- 4.5 ml.100 g-1.min-1 compared to the initial normoglycaemic flow of 49.5 +/- 3.7 ml.100 g-1.min-1 (p < 0.01). A further increase in global cerebral blood flow to 59.5 +/- 4.5 ml.100 g-1.min-1 (p < 0.05) occurred 15 min after normalization of the blood glucose level. The global cerebral blood flow change from before hypoglycaemia to after recovery was inversely related to the initial glucose level. No change in the relative distribution of the regional cerebral blood flow was found between the measurements. The cerebral blood flow was significantly higher in the right hemisphere compared with the left hemisphere (2.3, 1.6 and 2.2%, respectively; p < 0.05) in all measurements. Deeper hypoglycemia was associated with a more pronounced decrease in brain volume, while the length of the restitution time after hypoglycaemia correlated with a volume increase. Due to influences with opposite effects there was no mean change in the brain volume.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Hypoglycaemia
- cerebral blood flow
- brain volume
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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